Abstract：
UNLABELLED:Uterine sarcomas are heterogeneous malignancies, both clinically and histologically. The process of oncogenesis depends on gene mutations and uncontrolled mitotic cell division that is promoted by blocking pathways of apoptosis. Caspase 9 and p53 protein play an important role in the process of cell apoptosis. OBJECTIVES:The aim of the study was to assess the expression of selected apoptosis proteins (caspase 9 and p53) using immunohistochemistry. MATERIAL AND METHODS:A total of 28 tissue samples diagnosed in postoperative histopathological examination as leiomyosarcoma were tested. Twenty eight samples of leiomyomas were used as the control group. Colorful reactions with appropriate antibodies were performed to assess the expression of caspase 9 and p53. From every section 5 fields on view were chosen, in each one 100 cells were assessed using 400x magnification. T-Student parametric test and U Mann-Whitney test were used for statistical analysis. RESULTS:Expression of caspase 9 was significantly lower (p < 0.05) in leiomyosarcoma tissues (33.2%) as compared to leiomyomas (60.4%). Expression of p53 protein was significantly lower in leiomyosarcoma tissues than in leiomyomas (30.1% vs. 51.3%, p < 0.001). CONCLUSIONS:Significantly lower expression of caspase 9 and p53 in leiomyosarcoma tissue samples suggests that impaired deregulation of apoptosis mechanisms plays a role in the development of these tumors.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Kułak K,Bobiński M,Polak G,Jedrych BJ,Kotarski J,Bednarek Wdoi
10.17772/gp/1778subject
Has Abstractpub_date
2014-08-01 00:00:00pages
600-4issue
8eissn
0017-0011issn
2543-6767journal_volume
85pub_type
杂志文章abstract：:Since testes and adrenal cortex derive from the same urogenital ridge, adrenal tissue with descending gonads may migrate in early embryonic period. Although most often ectopic tissue undergoes atrophy in some cases, when adrenocorticotrophic (ACTH) overstimulation occurs, the adrenal remnants in the testes may become ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:Most pregnant women have little interest in thinking about the prospect of death. Mortality related to the pregnancy itself is rare, occurring in an estimated 1 of every 30 000 deliveries. Although cardiopulmonary arrest rarely occurs in pregnant women, it is important that the health care team knows the appropriate a...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-09-01 00:00:00
abstract：:Angiogenesis or the formation of new vessels out of pre-existing capillaries is a sequence of events that is fundamental to physiology of the female reproductive tract and also pathologic processes such as ovarian hyperstimulation syndrome. Many factors include vascular endothelial growth factor (VEGF), angiopoietins ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-08-01 00:00:00
abstract：OBJECTIVE:Ovarian inhibins (INH) are hormones participating in the regulation of gametogenesis. We monitored inhibin A and B levels in serum (S) and follicular fluids (FF), depending on the type of fertility failure and treatment outcome. MATERIAL AND METHODS:We examined INHA and B levels in S and FF of 72 women under...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/57844
更新日期：2015-10-01 00:00:00
abstract：:The results of large randomized trials such as the Women's Health Initiative (WHI), Heart and Estrogen / Progestin Replacement Study (HERS) or Estrogen Replacement and Atherosclerosis Study (ERAS) as well as the Million Women Study (MWS) which does not meet criteria RCT, concerning, among others the impact of HRT on b...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/61022
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:Recent studies have demonstrated that disorders of bone metabolism, which is regulated by RANK/RANKL/OPG signaling pathway, are the cause of osteoporosis. The aim of the study was to investigate the distribution of genotypes of the RANK 575C>T and RANKL -643C>T polymorphisms and to analyze their relationship...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0014
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:The evaluation of sexual life after hysterectomy is still controversial. DESIGN:The aim of the study was to analyse the impact of hysterectomy on frequency and quality of the woman's sexual life. MATERIAL AND METHODS:The total of 539 women operated in II Department of Obstetrics and Gynecology in 1990-2000...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and thrombocytopenia, accompanied by microvascular thrombosis that causes variable degrees of tissue ischemia and infarction. About 10-20% of TTP cases are associated with the pregnancy. Preterm delivery and intrauterine fe...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:We present a case of a female neonate, born at 36 weeks of gestation from a monochorionic, diamniotic spontaneous twin pregnancy with congenital epulis, 2.5 cm in size, protruding from the oral cavity. Histopathology revealed a typical granular cell lesion. The other twin, also female, was prenatally diagnosed with co...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1633
更新日期：2013-08-01 00:00:00
abstract：:The group of 100 men, divided into two groups according to WHO criteria concerning the spermatozoa content was evaluated. The group of 44 oligospermic and azoospermic men was compared with the control group consisting of 56 normospermic men by means of Mann-Whitney U. The statistically significant differences were est...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：UNLABELLED:Gestational Diabetes (GDM) is characterized by insulin resistance and a pro-inflammatory state, both factors possible related to adipokine expression. SUBJECTS AND METHODS:The study included 20 women with GDM, diagnosed according to the WHO criteria, and 23 matched for age and BMI women with normal glucose ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the incidence of placenta previa and to asses the relationship between the incidence of placenta previa and maternal age, parity, prior abortion and cesarean deliveries. MATERIALS AND METHODS:The records of all patients with the diagnosis of placenta previa during t...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2005-04-01 00:00:00
abstract：:We investigated the vitamin D receptor (VDR) and the estrogen receptor (ER) genes polymorphism in studied groups was similar, however the allelic combination BBPPxx was associated with low bone mineral mass. There is a need to perform genetic test in the cohort of polish women endangered by osteoporosis. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：:Bladder Pain Syndrome remains a great challenge for urologists, both in diagnostics and treatment. Etiopathogenesis of the disease is unknown. It is reported that the reason for Bladder Pain Syndrome is the urothelium dysfunction resulting in the destruction of the protective glycosaminoglycan layer/barrier protecting...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-03-01 00:00:00
abstract：:A monochorionic monoamniotic (MCMA) twin pregnancy is the rarest form of twin gestation, accounting for around 1:10000 to 1:20000 of all deliveries regardless of the region of the world. All multiple gestations have a higher risk of preterm delivery due to either preterm uterine contractions or asymptomatic cervical s...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-12-01 00:00:00
abstract：:Hypoxic-ischemic encephalopathy (ENN) concerns neonates born after 35 completed weeks of gestation. The incidence rate has been shown to be 1-6/1000 births and can lead to significant permanent neurological damage, cerebral palsy and even death. Until the whole body cooling and selective brain cooling methods have bee...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to verify clinical diagnosis of cervical incompetence by the use of transvaginal sonography. MATERIAL AND METHODS:101 pregnant women hospitalized at the Pathological Pregnancy Department, Medical University of Lodz in years 2000-2002 because of suspicion of cervical incompetence wer...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:The presence of estrogens, their function and targets in male reproductive tract are still not fully understood. Recent studies, basic and clinical indicate an important role of estrogens during germ cell development. In this study the efforts have been made to immunolocalize aromatase P450 as well as estrogen recepto...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Bezoars are the most common foreign bodies of gastrointestinal tract. They contain swallowed hair, different fibres, seeds, nut shells, sweets or drugs. Clinical manifestations vary, depending on the location and size of bezoar, from "no symptoms" to "acute abdomen" syndrome. In this case report, the authors describe ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVES:To assess the incidence of cervical intraepithelial neoplasia - SIL and cervical cancer in a population of pregnant women with an abnormal cytology. MATERIAL AND METHODS:In pregnant women with abnormal cytology results according to The Bethesda System, a verifying diagnostics was carried out, including colp...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2017.0004
更新日期：2017-01-01 00:00:00
abstract：:Among 94 women with diagnosed "primary" gestosis during pregnancy, 67 patients demonstrated (3-6 months after delivery) chronic glomerulonephritis (25 women) or chronic pyelonephritis (28 women) or hypertension caused by others than nephrologic reasons. "Primary" gestosis was diagnosed correctly only in 29% cases. The...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：OBJECTIVES:The aim of the paper was to assess nasal and oral amniotic fluid flows, with the use of color ultrasound and spectral Doppler, in normal fetuses. MATERIAL AND METHODS:Forty-six fetuses of singleton gestations were studied prospectively. Spectrum imaging and maximal nasal fluid flow velocities were described...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2018.0054
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses. MATERIAL AND METHODS:Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, A...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0045
更新日期：2016-01-01 00:00:00
abstract：:25 ovariectomized women mean age 47 +/- 5 years were treated with transdermal 17 beta Estradiol in the shape of Estraderm TTS 100 plasters. Drugs were administrated in 28 days cycles during 24 weeks. Chlormadinon in daily dose 2 mg was added from 16 to 28th day of the fourth therapeutic cycle. Total cholesterol, trigl...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：OBJECTIVES:G-CSF is a stimulatory factor of granulocyte colony formation. In vitro and in vivo G-CSF stimulates the proliferation of granulocyte precursors and enhances phagocytic functions of mature cells. Indirect evidence of this might be the increase of the activity of granulocyte enzymes participating in phagocyto...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2004-02-01 00:00:00
abstract：UNLABELLED:About 30% of women population in Poland is already in the perimenopausal age. HRT (hormonal replacement therapy) is the best way of diminishing the unfavorable symptoms of this state. AIM OF STUDY:The effect of HRT on ROI production by neutrophils before and after HRT, to determinate it's antioxidative infl...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-02-01 00:00:00
abstract：:Iniencephaly is a rare malformation characterized by the triad of occipital bone defect, cervical dysraphism and fixed retroflexion of the fetal head with poor prognosis. We present a case one of the twin with iniencephaly and congenital heart defect (common atrio-ventricular canal) with normal karyotype. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVES:The aim of the study is to determine the results of our initial experience of 32 cases who underwent single incision total laparoscopic hysterectomy MATERIALS AND METHODS:Thirty-two patients who underwent transumbilical single incision total laparoscopic hysterectomy between March 2009 and February 2011 wer...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to establish optimal diagnostic and therapeutic scheme and to assess the efficacy of intrauterine therapy of hydrocephalus. MATERIAL AND METHODS:The study was carried out between 1992-2012 on the total of 222 fetuses with hydro- cephalus, using Orbis-Sigma and ACCU-Flow valves (168 c...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVES:Evaluate the time dependent expression of genes in preterm neonates and verify the influence of ontogenic maturation and the environmental factors on the gene expression after birth. MATERIAL AND METHODS:The study was carried out on 20 full-term newborns and 62 preterm newborns (mean birth weight = 1002 [g]...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2017.0080
更新日期：2017-01-01 00:00:00
