Transcriptional analysis of the principal cell division gene, ftsZ, of Mycobacterium tuberculosis.

Abstract:

:Multiple promoters drive the expression of the principal cell division gene, ftsZ, in bacterial systems. Primer extension analysis of total RNA from Mycobacterium tuberculosis and a Mycobacterium smegmatis transformant containing 1.117 kb of the upstream region of M. tuberculosis ftsZ and promoter fusion studies identified six ftsZ transcripts and their promoters in the ftsQ open reading frame and ftsQ-ftsZ intergenic region. The presence of multiple promoters reflects the requirement to maintain a high basal level of, or to differentially regulate, FtsZ expression during different growth conditions of the pathogen in vivo.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Roy S,Ajitkumar P

doi

10.1128/JB.187.7.2540-2550.2005

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

2540-50

issue

7

eissn

0021-9193

issn

1098-5530

pii

187/7/2540

journal_volume

187

pub_type

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