Abstract:
:Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.
journal_name
EMBO Repjournal_title
EMBO reportsauthors
Zaidi SK,Young DW,Choi JY,Pratap J,Javed A,Montecino M,Stein JL,van Wijnen AJ,Lian JB,Stein GSdoi
10.1038/sj.embor.7400337keywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
128-33issue
2eissn
1469-221Xissn
1469-3178pii
7400337journal_volume
6pub_type
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