EB1 is essential during Drosophila development and plays a crucial role in the integrity of chordotonal mechanosensory organs.

abstract：:During meiosis, homologues are linked by crossover, which is required for bipolar chromosome orientation before chromosome segregation at anaphase I. The repetitive ribosomal DNA (rDNA) array, however, undergoes little or no meiotic recombination. Hyperrecombination can cause chromosome missegregation and rDNA copy nu...

journal_title：Molecular biology of the cell

authors： Li P,Jin H,Yu HG

更新日期：2014-10-01 00:00:00

abstract：:As yeast cultures enter stationary phase in rich, glucose-based medium, differentiation of two major subpopulations of cells, termed quiescent and nonquiescent, is observed. Differences in mRNA abundance between exponentially growing and stationary-phase cultures and quiescent and nonquiescent cells are known, but lit...

journal_title：Molecular biology of the cell

authors： Davidson GS,Joe RM,Roy S,Meirelles O,Allen CP,Wilson MR,Tapia PH,Manzanilla EE,Dodson AE,Chakraborty S,Carter M,Young S,Edwards B,Sklar L,Werner-Washburne M

更新日期：2011-04-01 00:00:00

abstract：:Differentiation and polarization of epithelial cells depends on the formation of the apical junctional complex (AJC), which is composed of the tight junction (TJ) and the adherens junction (AJ). In this study, we investigated mechanisms of actin reorganization that drive the establishment of AJC. Using a calcium switc...

journal_title：Molecular biology of the cell

authors： Ivanov AI,Hunt D,Utech M,Nusrat A,Parkos CA

更新日期：2005-06-01 00:00:00

abstract：:Activation of the inflammatory response is accompanied by a metabolic shift to aerobic glycolysis. Here we identify histone deacetylase 4 (HDAC4) as a new component of the immunometabolic program. We show that HDAC4 is required for efficient inflammatory cytokine production activated by lipopolysaccharide (LPS). Surpr...

journal_title：Molecular biology of the cell

authors： Wang B,Liu TY,Lai CH,Rao YH,Choi MC,Chi JT,Dai JW,Rathmell JC,Yao TP

更新日期：2014-11-01 00:00:00

abstract：:MPM-2 antigens, a discrete set of phosphoproteins that contain similar phosphoepitopes recognized by the monoclonal antibody MPM-2, are phosphorylated during M-phase induction. Our previous studies suggested that certain MPM-2 antigens are involved in the appearance of maturation-promoting factor (MPF) activity. Becau...

journal_title：Molecular biology of the cell

authors： Kuang J,Ashorn CL,Gonzalez-Kuyvenhoven M,Penkala JE

更新日期：1994-02-01 00:00:00

abstract：:Cell emergence onto damaged or organized fibrous extracellular matrix (ECM) is a crucial precursor to collective cell migration in wound closure and cancer metastasis, respectively. However, there is a fundamental gap in our quantitative understanding of the role of local ECM size and arrangement in cell emergence-bas...

journal_title：Molecular biology of the cell

authors： Sharma P,Ng C,Jana A,Padhi A,Szymanski P,Lee JSH,Behkam B,Nain AS

更新日期：2017-09-15 00:00:00

abstract：:MicroRNAs (miRNAs), the tiny regulatory RNAs, form complexes with Argonaute (Ago) proteins and inhibit gene expression in metazoan cells. While studying parasite-invaded macrophages, we identify a unique mode of gene regulation in which the parasite Leishmania donovani (Ld) causes mitochondrial depolarization, reduces...

journal_title：Molecular biology of the cell

authors： Chakrabarty Y,Bhattacharyya SN

更新日期：2017-07-15 00:00:00

abstract：:Hansenula polymorpha ass3 mutants are characterized by the accumulation of inactive alcohol oxidase (AO) monomers in the cytosol, whereas other peroxisomal matrix proteins are normally activated and sorted to peroxisomes. These mutants also have a glutamate or aspartate requirement on minimal media. Cloning of the cor...

journal_title：Molecular biology of the cell

authors： Ozimek P,van Dijk R,Latchev K,Gancedo C,Wang DY,van der Klei IJ,Veenhuis M

更新日期：2003-02-01 00:00:00

abstract：:Jak tyrosine kinases have a unique domain structure containing a kinase domain (JH1) adjacent to a catalytically inactive pseudokinase domain (JH2). JH2 is crucial for inhibition of basal Jak activity, but the mechanism of this regulation has remained elusive. We show that JH2 negatively regulated Jak2 in bacterial ce...

journal_title：Molecular biology of the cell

authors： Saharinen P,Vihinen M,Silvennoinen O

更新日期：2003-04-01 00:00:00

abstract：:Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Drosophila RasGAP gene, ...

journal_title：Molecular biology of the cell

authors： Botella JA,Kretzschmar D,Kiermayer C,Feldmann P,Hughes DA,Schneuwly S

更新日期：2003-01-01 00:00:00

abstract：:Mitochondrial decline is a hallmark of aging, and cells are equipped with many systems to regulate mitochondrial structure and function in response to stress and metabolic alterations. Here, using budding yeast, we identify a proteolytic pathway that contributes to alterations in mitochondrial structure in aged cells ...

journal_title：Molecular biology of the cell

authors： Goodrum JM,Lever AR,Coody TK,Gottschling DE,Hughes AL

更新日期：2019-08-01 00:00:00

abstract：:Profilin controls actin nucleation and assembly processes in eukaryotic cells. Actin nucleation and elongation promoting factors (NEPFs) such as Ena/VASP, formins, and WASP-family proteins recruit profilin:actin for filament formation. Some of these are found to be microtubule associated, making actin polymerization f...

journal_title：Molecular biology of the cell

authors： Nejedla M,Sadi S,Sulimenko V,de Almeida FN,Blom H,Draber P,Aspenström P,Karlsson R

更新日期：2016-08-01 00:00:00

abstract：:The Caenorhabditis elegans oocyte is a highly amenable system for forward and reverse genetic analysis of receptor-mediated endocytosis. We describe the use of transgenic strains expressing a vitellogenin::green fluorescent protein (YP170::GFP) fusion to monitor yolk endocytosis by the C. elegans oocyte in vivo. This ...

journal_title：Molecular biology of the cell

authors： Grant B,Hirsh D

更新日期：1999-12-01 00:00:00

abstract：:Collective cell migration is emerging as a major contributor to normal development and disease. Collective movement of border cells in the Drosophila ovary requires cooperation between two distinct cell types: four to six migratory cells surrounding two immotile cells called polar cells. Polar cells secrete a cytokine...

journal_title：Molecular biology of the cell

authors： Xiang W,Zhang D,Montell DJ

更新日期：2016-01-01 00:00:00

abstract：:We have identified five complementation groups of peroxisome biogenesis (peb) mutants in Saccharomyces cerevisiae by a positive selection procedure. Three of these contained morphologically recognizable peroxisomes, and two appeared to lack the organelle altogether. The packaging of peroxisomal proteins in these mutan...

journal_title：Molecular biology of the cell

authors： Zhang JW,Luckey C,Lazarow PB

更新日期：1993-12-01 00:00:00

abstract：:Cohesion establishment and maintenance are carried out by proteins that modify the activity of Cohesin, an essential complex that holds sister chromatids together. Constituents of the replication fork, such as the DNA polymerase alpha-binding protein Ctf4, contribute to cohesion in ways that are poorly understood. To ...

journal_title：Molecular biology of the cell

authors： Warren CD,Eckley DM,Lee MS,Hanna JS,Hughes A,Peyser B,Jie C,Irizarry R,Spencer FA

更新日期：2004-04-01 00:00:00

abstract：:Glycerol and other polyols are used as osmoprotectants by many organisms. Several yeasts and other fungi can take up glycerol by proton symport. To identify genes involved in active glycerol uptake in Saccharomyces cerevisiae we screened a deletion mutant collection comprising 321 genes encoding proteins with 6 or mor...

journal_title：Molecular biology of the cell

authors： Ferreira C,van Voorst F,Martins A,Neves L,Oliveira R,Kielland-Brandt MC,Lucas C,Brandt A

更新日期：2005-04-01 00:00:00

abstract：:We previously characterized major components of mitotic chromosomes assembled in Xenopus laevis egg extracts and collectively referred to them as Xenopus chromosome-associated polypeptides (XCAPs). They included five subunits of the condensin complex essential for chromosome condensation. In an effort to identify nove...

journal_title：Molecular biology of the cell

authors： MacCallum DE,Losada A,Kobayashi R,Hirano T

更新日期：2002-01-01 00:00:00

abstract：:"Lipid raft" is the name given to the tiny, dynamic, and ordered domains of cholesterol and sphingolipids that are hypothesized to exist in the plasma membranes of eukaryotic cells. According to the lipid raft hypothesis, these cholesterol- and sphingolipid-enriched domains modulate the protein-protein interactions th...

journal_title：Molecular biology of the cell

authors： Kraft ML

更新日期：2013-09-01 00:00:00

abstract：:Intracellular trafficking of tRNA was long thought to be a one-way trip from the site of biogenesis in the nucleus to the translation machinery in the cytoplasm. This view has recently been challenged, however, by the discovery that tRNA can move retrograde from the cytoplasm back to the nucleus in Saccharomyces cerev...

journal_title：Molecular biology of the cell

authors： Chafe SC,Pierce JB,Eswara MB,McGuire AT,Mangroo D

更新日期：2011-04-01 00:00:00

abstract：:The zona pellucida (ZP) is a highly organized extracellular coat that surrounds all mammalian eggs. The mouse egg ZP is composed of three glycoproteins, called mZP1-3, that are synthesized, secreted, and assembled into a ZP exclusively by growing oocytes. Here, we microinjected epitope-tagged (Myc and Flag) cDNAs for ...

journal_title：Molecular biology of the cell

authors： Qi H,Williams Z,Wassarman PM

更新日期：2002-02-01 00:00:00

abstract：:Scientific societies aiming to foster inclusion of scientists from underrepresented (UR) backgrounds among their membership often delegate primary responsibility for this goal to a diversity-focused committee. The National Science Foundation has funded the creation of the Alliance to Catalyze Change for Equity in STEM...

journal_title：Molecular biology of the cell

authors： Segarra VA,Primus C,Unguez GA,Edwards A,Etson C,Flores SC,Fry C,Guillory AN,Ingram SL,Lawson M,McGee R,Paxson S,Phelan L,Suggs K,Vega LR,Vuong E,Havran JC,Leon A,Burton MD,Lujan JL,Ramirez-Alvarado M

更新日期：2020-11-01 00:00:00

abstract：:In complex with FKBP12, the immunosuppressant rapamycin binds to and inhibits the yeast TOR1 and TOR2 proteins and the mammalian homologue mTOR/FRAP/RAFT1. The TOR proteins promote cell cycle progression in yeast and human cells by regulating translation and polarization of the actin cytoskeleton. A C-terminal domain ...

journal_title：Molecular biology of the cell

authors： Alarcon CM,Heitman J,Cardenas ME

更新日期：1999-08-01 00:00:00

abstract：:Phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] and phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P(3)] are phosphoinositides (PIs) present in small amounts in the inner leaflet of the plasma membrane (PM) lipid bilayer of host target cells. They are thought to modulate the activity of proteins involved in en...

journal_title：Molecular biology of the cell

authors： Sason H,Milgrom M,Weiss AM,Melamed-Book N,Balla T,Grinstein S,Backert S,Rosenshine I,Aroeti B

更新日期：2009-01-01 00:00:00

abstract：:Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins associate longitudinally to form protofilaments, and adjacent protofilaments associate laterally to form the microtubule. In the textbook view, microtubules are 1) composed of 13 protofilaments, 2) arranged in a radial array ...

journal_title：Molecular biology of the cell

authors： Chaaban S,Brouhard GJ

更新日期：2017-11-01 00:00:00

abstract：:Conformational diseases are associated with the conversion of normal proteins into aggregation-prone toxic conformers with structures similar to that of β-amyloid. Spatial distribution of amyloid-like proteins into intracellular quality control centers can be beneficial, but cellular mechanisms for protective aggregat...

journal_title：Molecular biology of the cell

authors： Wolfe KJ,Ren HY,Trepte P,Cyr DM

更新日期：2013-12-01 00:00:00

abstract：:Cellular responses to environmental changes occur on different levels. We investigated the translational response of yeast cells after mild hyperosmotic shock by isolating mRNA associated with multiple ribosomes (polysomes) followed by array analysis. Globally, recruitment of preexisting mRNAs to ribosomes (translatio...

journal_title：Molecular biology of the cell

authors： Warringer J,Hult M,Regot S,Posas F,Sunnerhagen P

更新日期：2010-09-01 00:00:00

abstract：:We identified a novel interaction between myosin VI and the GLUT1 transporter binding protein GLUT1CBP(GIPC1) and first proposed that as an adapter molecule it might function to couple vesicle-bound proteins to myosin VI movement. This study refines the model by identifying two myosin VI binding domains in the GIPC1 C...

journal_title：Molecular biology of the cell

authors： Reed BC,Cefalu C,Bellaire BH,Cardelli JA,Louis T,Salamon J,Bloecher MA,Bunn RC

更新日期：2005-09-01 00:00:00

abstract：:ATP8A2 is a P4-ATPase that flips phosphatidylserine and phosphatidylethanolamine across cell membranes. This generates membrane phospholipid asymmetry, a property important in many cellular processes, including vesicle trafficking. ATP8A2 deficiency causes severe neurodegenerative diseases. We investigated the role of...

journal_title：Molecular biology of the cell

authors： Chalat M,Moleschi K,Molday RS

更新日期：2017-02-01 00:00:00

abstract：:The spindle checkpoint prevents anaphase onset until all the chromosomes have successfully attached to the spindle microtubules. The mechanisms by which unattached kinetochores trigger and transmit a primary signal are poorly understood, although it seems to be dependent at least in part, on the kinetochore localizati...

journal_title：Molecular biology of the cell

authors： Vigneron S,Prieto S,Bernis C,Labbé JC,Castro A,Lorca T

更新日期：2004-10-01 00:00:00