Abstract:
:Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Drosophila RasGAP gene, which encodes a Ras GTPase-activating protein. These mutants show age-related brain degeneration that is dependent on activation of the EGF receptor signaling pathway in adult neurons, leading to autophagic cell death (cell death type 2). These results provide the first evidence for a requirement of Egf receptor activity in differentiated adult Drosophila neurons and show that a delicate balance of Ras activity is essential for the survival of adult neurons.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Botella JA,Kretzschmar D,Kiermayer C,Feldmann P,Hughes DA,Schneuwly Sdoi
10.1091/mbc.e02-05-0297keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
241-50issue
1eissn
1059-1524issn
1939-4586journal_volume
14pub_type
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