Abstract:
:"Lipid raft" is the name given to the tiny, dynamic, and ordered domains of cholesterol and sphingolipids that are hypothesized to exist in the plasma membranes of eukaryotic cells. According to the lipid raft hypothesis, these cholesterol- and sphingolipid-enriched domains modulate the protein-protein interactions that are essential for cellular function. Indeed, many studies have shown that cellular levels of cholesterol and sphingolipids influence plasma membrane organization, cell signaling, and other important biological processes. Despite 15 years of research and the application of highly advanced imaging techniques, data that unambiguously demonstrate the existence of lipid rafts in mammalian cells are still lacking. This Perspective summarizes the results that challenge the lipid raft hypothesis and discusses alternative hypothetical models of plasma membrane organization and lipid-mediated cellular function.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Kraft MLdoi
10.1091/mbc.E13-03-0165subject
Has Abstractpub_date
2013-09-01 00:00:00pages
2765-8issue
18eissn
1059-1524issn
1939-4586pii
24/18/2765journal_volume
24pub_type
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