Abstract:
:A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. Indeed, upon heat shock, HSF1, in addition to its well-known transactivating activities, mediates a genome-wide and massive histone deacetylation. Investigating the underlying mechanisms, we show that HSF1 specifically associates with and uses HDAC1 and HDAC2 to trigger this heat-shock-dependent histone deacetylation. This work therefore identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
Fritah S,Col E,Boyault C,Govin J,Sadoul K,Chiocca S,Christians E,Khochbin S,Jolly C,Vourc'h Cdoi
10.1091/mbc.e09-04-0295subject
Has Abstractpub_date
2009-12-01 00:00:00pages
4976-84issue
23eissn
1059-1524issn
1939-4586pii
E09-04-0295journal_volume
20pub_type
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