Abstract:
:While different markers for cancer diagnosis have been known for at least a decade, the systematic search for biomarkers emerged only several years ago. In this article, I will concentrate on DNA methylation as a dynamic and robust platform for the development of cancer-specific biomarkers. Simultaneous analysis of a growing number of independent methylation events can create increasingly more precise and individualized diagnostics. The differential detection of methylated and unmethylated DNA can be accomplished through either chemical modification or digestion with methylation-sensitive restriction enzyme(s). The benefits and potential pitfalls of both these approaches for clinical sample analysis will be addressed.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Levenson VVdoi
10.1517/14622416.5.6.699keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
699-707issue
6eissn
1462-2416issn
1744-8042pii
PGS050611journal_volume
5pub_type
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