Abstract:
:Aim: To determine if selected serotonergic and noradrenergic gene variants are associated with heroin addiction. Subjects & methods: A total of 126 variants in 19 genes in subjects with Dutch European ancestry from The Netherlands. Subjects included 281 opioid-dependent volunteers in methadone maintenance or heroin-assisted treatment, 163 opioid-exposed but not opioid-dependent volunteers who have been using illicit opioids but never became opioid-dependent and 153 healthy controls. Results: Nominal associations were indicated for 20 variants in six genes including an experiment-wise significant association from the combined effect of three SLC18A2 SNPs (rs363332, rs363334 and rs363338) with heroin dependence (pfinal = 0.047). Conclusion: Further studies are warranted to confirm and elucidate the role of these variants in the vulnerability to opioid addiction.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Randesi M,van den Brink W,Levran O,Blanken P,van Ree JM,Ott J,Kreek MJdoi
10.2217/pgs-2018-0137subject
Has Abstractpub_date
2019-04-01 00:00:00pages
331-341issue
5eissn
1462-2416issn
1744-8042journal_volume
20pub_type
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