Abstract:
:Damage to the heart can result from both traditional chemotherapeutic agents, such as doxorubicin, and newer 'targeted' therapies, such as trastuzumab. This chemotherapeutic cardiotoxicity is potentially life-threatening and necessitates limiting or discontinuing an otherwise-effective cancer treatment. Clinical strategies focus on surveillance rather than prevention, although there are no specific therapies for this highly morbid adverse effect. Current models for prospectively predicting risk of chemotherapeutic cardiotoxicity are limited. Cardiotoxicity can occur idiosyncratically in patients without obvious demographic risk factors, suggesting a genetically determined susceptibility, and candidate-gene studies have identified a limited number of variants that increase risk. In this commentary we indicate a need for more powerful means to identify risk prospectively, and suggest that broad pharmacogenomic approaches may be fruitful.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Jensen BC,McLeod HLdoi
10.2217/pgs.12.205subject
Has Abstractpub_date
2013-01-01 00:00:00pages
205-13issue
2eissn
1462-2416issn
1744-8042journal_volume
14pub_type
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