Abstract:
:Many biomarkers indicate prognosis in chronic lymphocytic leukemia; such as fluorescence in situ hybridization testing: 17p or 11q deletions have a worse prognosis than trisomy 12, 13q deletion or normal result, or the mutational status of the immunoglobulin heavy chain (IGHV): unmutated IGHV have a worse prognosis than mutated IGHV. Recently, many gene mutations (TP53, NOTCH1 etc.,) have been linked to a worse prognosis. With the new era of high-throughput sequencing, it has become easier to study gene mutations and their implication in predicting prognosis. In this review, we aim to review all the studies that performed whole-exome sequencing or whole-genome sequencing on chronic lymphocytic leukemia cells and explore the implication of various genes in disease prognosis.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Hobeika C,Rached G,Chebly A,Chouery E,Kourie HRdoi
10.2217/pgs-2020-0022subject
Has Abstractpub_date
2020-08-01 00:00:00pages
957-962issue
13eissn
1462-2416issn
1744-8042journal_volume
21pub_type
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