Abstract:
:Genome-wide association studies (GWAS) allow the finding of genetic variants associated with several traits. Regarding ovarian cancer (OC), 15 GWAS have been conducted since 2009, with the discovery of 49 SNPs associated with disease susceptibility and 46 with impact in the clinical outcome of patients (p < 5.00 × 10-2). Among them, 14 variants reached the genome-wide significance (p < 5.00 × 10-8). Despite the results obtained, they should be validated in independent sets. So far, five validation studies have been conducted which could confirm the association of 12 OC susceptibility SNPs. Consequently, post-GWAS studies are crucial unravel the biological plausibility of GWAS' findings and the allelic spectrum of OC.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Pinto R,Assis J,Nogueira A,Pereira C,Pereira D,Medeiros Rdoi
10.2217/pgs-2017-0108subject
Has Abstractpub_date
2017-11-01 00:00:00pages
1611-1625issue
17eissn
1462-2416issn
1744-8042journal_volume
18pub_type
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