Abstract:
:The advent of multiplexing technologies has raised the possibility that disease states can be defined using discrete genomic and proteomic patterns or signatures. However, this emerging area has been limited by the 'content problem', arising from the uncertainty of which molecules to focus on. The human cluster of differentiation (CD) antigens are expressed on cells of the human immune system (leukocytes) and on other cell types. These heterogeneous molecules perform a host of roles essential to immune function and to the physiology of other lineages. The 339 defined CD antigens and their, as yet, undefined counterparts constitute key components of the expressed human cell surface proteome. We propose that CD antigen expression patterns will form the basis of a rational, discrete and generalized diagnostic and prognostic system. Furthermore, disease-specific CD antigen proteomic signatures are likely to be more robust than corresponding genomic signatures and will also help to identify molecular targets for therapeutic intervention.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Woolfson A,Ellmark P,Chrisp JS,A Scott M,Christopherson RIdoi
10.2217/14622416.7.5.759subject
Has Abstractpub_date
2006-07-01 00:00:00pages
759-71issue
5eissn
1462-2416issn
1744-8042journal_volume
7pub_type
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