Abstract:
:Recent studies have suggested an association between mutations in the IL-36RN gene and the onset of pustular generalized. In the literature, only one case of acute generalized exanthematous pustulosis (AGEP) induced by codeine in a patient with IL36RN mutation has been reported. Herein, we reported an unusual case of AGEP caused by codeine in a patient with a history of psoriasis and confirmed by an oral provocation test. In this case, we have shown that the IL36RN gene mutation is not a constant condition in drug-induced AGEP. Clinicians should be aware of this side effect of codeine especially, in patients with a history of psoriasis. More studies are needed to clarify the association between drug-induced AGEP and IL36RN gene mutations.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Chadli Z,Ladhari C,Kerkeni E,Djobbi A,Fredj NB,Chaabane A,Boughattas NA,Aouam Kdoi
10.2217/pgs-2017-0200subject
Has Abstractpub_date
2018-07-01 00:00:00pages
889-893issue
11eissn
1462-2416issn
1744-8042journal_volume
19pub_type
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