Abstract:
AIM:We conducted a genome-wide association study using the Illumina Exome Array to identify coding SNPs that may explain additional warfarin dose variability. PATIENTS & METHODS:Analysis was performed after adjustment for clinical variables and genetic factors known to influence warfarin dose among 1680 warfarin users (838 European-Americans and 842 African-Americans). Replication was performed in an independent sample. RESULTS:We confirmed the influence of known genetic variants on warfarin dose variability. Our study is the first to show the association between rs12772169 and warfarin dose in African-Americans. In addition, genes COX15 and FGF5 showed significant association in European-Americans. CONCLUSION:We identified some novel genes/SNPs that underpin warfarin dose response. Further replication is needed to confirm our findings.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Liu N,Irvin MR,Zhi D,Patki A,Beasley TM,Nickerson DA,Hill CE,Chen J,Kimmel SE,Limdi NAdoi
10.2217/pgs-2017-0046subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1059-1073issue
11eissn
1462-2416issn
1744-8042journal_volume
18pub_type
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