Abstract:
:The recent advent of induced pluripotent stem cells has enabled the study of patient-specific and disease-related neurons in vitro and has facilitated new directions of inquiry into disease mechanisms. With these approaches, we now have the possibility of correlating ex vivo cellular phenotypes with individual patient response to treatment and/or side effects, which makes targeted treatments for schizophrenia and bipolar disorder a distinct prospect in the coming years. Here, we briefly review the current state of stem cell-based models and explore studies that are providing new insights into the disease biology of schizophrenia and bipolar disorder, which are laying the foundations for the development of novel targeted therapies.
journal_name
Pharmacogenomicsjournal_title
Pharmacogenomicsauthors
Watmuff B,Liu B,Karmacharya Rdoi
10.2217/pgs-2016-0187subject
Has Abstractpub_date
2017-04-01 00:00:00pages
471-479issue
5eissn
1462-2416issn
1744-8042journal_volume
18pub_type
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