Analysis and evaluation of a biomedical polycarbonate urethane tested in an in vitro study and an ovine arthroplasty model. Part I: materials selection and evaluation.

abstract：:Poly(ether-ether-ketone) (PEEK) has been used as a load bearing orthopaedic implant material with clinical success. All of the orthopaedic applications contain stress concentrations (notches) in their design; however, little work has been done to examine the fatigue behavior of PEEK in the presence of a notch. This wo...

journal_title：Biomaterials

authors： Sobieraj MC,Murphy JE,Brinkman JG,Kurtz SM,Rimnac CM

更新日期：2010-12-01 00:00:00

abstract：:A perfect "off" to "on" switch of the therapeutic function is very important to minimize the phototoxicity of nanoplatforms assisted imaging-guided photodynamic therapy (PDT) of cancer. Current approaches rely on preloaded photosensitizers, where the off/on state of PDT is regulated by the sensitizing light of photose...

journal_title：Biomaterials

authors： Feng Y,Wu Y,Zuo J,Tu L,Que I,Chang Y,Cruz LJ,Chan A,Zhang H

更新日期：2019-05-01 00:00:00

abstract：:Nanocrystalline diamond (NCD) films and nanoparticulate diamond powder (DP) are the two main representatives of diamond at the nanoscale. This study was designed to investigate the suitability of these biomaterials as cell growth supports and to determine surface characteristic properties best suited to cell attachmen...

journal_title：Biomaterials

authors： Lechleitner T,Klauser F,Seppi T,Lechner J,Jennings P,Perco P,Mayer B,Steinmüller-Nethl D,Preiner J,Hinterdorfer P,Hermann M,Bertel E,Pfaller K,Pfaller W

更新日期：2008-11-01 00:00:00

abstract：:Cell processes, including growth cones, respond to biophysical cues in their microenvironment to establish functional tissue architecture and intercellular networks. The mechanisms by which cells sense and translate biophysical cues into directed growth are unknown. We used photopolymerization to fabricate methacrylat...

journal_title：Biomaterials

authors： Li S,Tuft BW,Xu L,Polacco MA,Clarke JC,Guymon CA,Hansen MR

更新日期：2015-06-01 00:00:00

abstract：:This paper presents a phenomenological diffusion-reaction model for the biodegradation of biodegradable polymers. The biodegradation process is modelled using a set of simplified reaction-diffusion equations. These partial differential equations are non-dimensionalised giving two normalised parameters which control th...

journal_title：Biomaterials

authors： Wang Y,Pan J,Han X,Sinka C,Ding L

更新日期：2008-08-01 00:00:00

abstract：:Transcutaneous immunization (TCI) is an attractive vaccination method compared with conventional injectable vaccines because it is easier to administer without pain. We developed a dissolving microneedle patch (MicroHyala, MH) made of hyaluronic acid and showed that transcutaneous vaccination using MH induced a strong...

journal_title：Biomaterials

authors： Hirobe S,Azukizawa H,Hanafusa T,Matsuo K,Quan YS,Kamiyama F,Katayama I,Okada N,Nakagawa S

更新日期：2015-07-01 00:00:00

abstract：:Porous scaffolds for skin tissue engineering were fabricated by freeze-drying the mixture of collagen and chitosan solutions. Glutaraldehyde (GA) was used to treat the scaffolds to improve their biostability. Confocal laser scanning microscopy observation confirmed the even distribution of these two constituent materi...

journal_title：Biomaterials

authors： Ma L,Gao C,Mao Z,Zhou J,Shen J,Hu X,Han C

更新日期：2003-11-01 00:00:00

abstract：:Nanocomposite of hydroxyapatite (HAP) surface-grafted with poly(l-lactide) (PLLA) (g-HAP) shows a wide application for bone fixation materials due to its improved interface compatibility, mechanical property and biocompatibility in our previous study. In this paper, a 3-D porous scaffold of g-HAP/poly(lactide-co-glyco...

journal_title：Biomaterials

authors： Zhang P,Hong Z,Yu T,Chen X,Jing X

更新日期：2009-01-01 00:00:00

abstract：:Amorphous carbon films have attracted much attention recently due to their good biocompatibility. Diamond-like carbon (DLC), one form of amorphous carbon that is widely used in many kinds of industries, has been proposed for use in blood contacting medical devices. However, the blood coagulation mechanism on DLC in a ...

journal_title：Biomaterials

authors： Yang P,Huang N,Leng YX,Chen JY,Fu RK,Kwok SC,Leng Y,Chu PK

更新日期：2003-08-01 00:00:00

abstract：:This study is aimed to develop a long-acting injectable formulation in treatment of type II diabetes. A glucoregulatory polypeptide, exenatide (EXT), was chosen as the model drug, and an aqueous block copolymer system with a sol-gel transition upon the increase of temperature was selected as the delivery matrix of EXT...

journal_title：Biomaterials

authors： Li K,Yu L,Liu X,Chen C,Chen Q,Ding J

更新日期：2013-04-01 00:00:00

abstract：:Mononuclear phagocyte system is the first target for injected nanomaterials. Monocytes/macrophages are the central actors for trafficking and clearance of magnetic nanoparticles in vivo. However the fate of nanosized magnetic label is an ongoing issue. Here we demonstrate that the monocyte/macrophage system shows a co...

journal_title：Biomaterials

authors： Luciani N,Wilhelm C,Gazeau F

更新日期：2010-09-01 00:00:00

abstract：:One of the major challenges in engineering thick, complex tissues such as cardiac muscle, is the need to pre-vascularize the engineered tissue in vitro to enable its efficient integration with host tissue upon implantation. Herein, we explored new magnetic alginate composite scaffolds to provide means of physical stim...

journal_title：Biomaterials

authors： Sapir Y,Cohen S,Friedman G,Polyak B

更新日期：2012-06-01 00:00:00

abstract：:Load-bearing tissues, like bone, can be replaced by engineered tissues or tissue constructs. For the success of this treatment, a profound understanding is needed of the mechanical properties of both the native bone tissue and the construct. Also, the interaction between mechanical loading and bone regeneration and ad...

journal_title：Biomaterials

authors： Jaecques SV,Van Oosterwyck H,Muraru L,Van Cleynenbreugel T,De Smet E,Wevers M,Naert I,Vander Sloten J

更新日期：2004-04-01 00:00:00

abstract：:We investigated the in vitro effects of the molecular weight (MW) of hyaluronic acid (HA) on the maintenance of the pluripotency and proliferation of murine embryonic stem (ES) cells. High (1000 kDa) or low (4-8 kDa) MW HA was derivatized using an ultraviolet-reactive compound, 4-azidoaniline, and the derivative was i...

journal_title：Biomaterials

authors： Joddar B,Kitajima T,Ito Y

更新日期：2011-11-01 00:00:00

abstract：:Biodegradable and pH-sensitive hydrogels containing azoaromatic moieties were synthesized from the same polymeric precursors by two synthetic methods, namely a polymer-polymer reaction and cross-linking of polymeric precursors. The effect of the synthetic route employed and the detailed network structure on in vitro d...

journal_title：Biomaterials

authors： Ghandehari H,Kopecková P,Kopecek J

更新日期：1997-06-01 00:00:00

abstract：:Primary rat bone marrow cells were cultured for periods of 8 d on hydroxyapatite discs produced by sintering compressed powder at 1130 degrees C. The disc surfaces were roughened using silicon carbide paper to create three groups of samples (n = 10) of differing surface topography. The culture conditions permitted bot...

journal_title：Biomaterials

authors： Gomi K,Lowenberg B,Shapiro G,Davies JE

更新日期：1993-01-01 00:00:00

abstract：:Because tissues are characterized by a well-defined three-dimensional arrangement of cells, tissue engineering scaffolds that facilitate the organization and differentiation of new tissue will have improved performance in comparison to scaffolds that only provide surfaces for cell attachment and growth. We hypothesize...

journal_title：Biomaterials

authors： Koegler WS,Griffith LG

更新日期：2004-06-01 00:00:00

abstract：:The long-term behaviour of cellulose sponge implants, 10 x 10 x 5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically...

journal_title：Biomaterials

authors： Märtson M,Viljanto J,Hurme T,Laippala P,Saukko P

更新日期：1999-11-01 00:00:00

abstract：:A variety of techniques have been applied to generate tissue engineered constructs, where cells are combined with degradable scaffolds followed by a period of in vitro culture or direct implantation. In the current study, a cellularized scaffold was generated by concurrent deposition of electrospun biodegradable elast...

journal_title：Biomaterials

authors： Takanari K,Hashizume R,Hong Y,Amoroso NJ,Yoshizumi T,Gharaibeh B,Yoshida O,Nonaka K,Sato H,Huard J,Wagner WR

更新日期：2017-01-01 00:00:00

abstract：:Heat treatment of an MgO-CaO-SiO2-P2O5 glass gave a glass ceramic containing crystalline apatite (Ca10(PO4)6O,F2] and beta-wollastonite (CaO,SiO2) in an MgO-CaO-SiO2 glassy matrix. It showed bioactivity and a fairly high mechanical strength which decreased only slowly, even under load-bearing conditions in the body. I...

journal_title：Biomaterials

authors： Kokubo T

更新日期：1991-03-01 00:00:00

abstract：:Surface biofouling poses an increasing problem in industrial and health care applications, driving research for surface coatings to prevent anti-microbial colonization and characterization of the efficacy of the same. The diversity and increasing sophistication of such coatings, which postulate different types of anti...

journal_title：Biomaterials

authors： Xie X,Möller J,Konradi R,Kisielow M,Franco-Obregón A,Nyfeler E,Mühlebach A,Chabria M,Textor M,Lu Z,Reimhult E

更新日期：2011-07-01 00:00:00

abstract：:Poly(ortho esters) with a low glass transition temperature are semi-solid materials so that therapeutic agents can be incorporated at room temperature, without the use of solvents, by a simple mixing procedure. When molecular weights are limited to < 5 kDa, such materials are directly injectable using a needle size no...

journal_title：Biomaterials

authors： Helle J,Barr J,Ng SY,Shen HR,Schwach-Abdellaoui K,Gurny R,Vivien-Castioni N,Loup PJ,Baehni P,Mombelli A

更新日期：2002-11-01 00:00:00

abstract：:We show here, that the proapoptotic peptide, KLAKLAKKLAKLAK (KLA), which by itself does not penetrate cell membranes, can do so when fused to a protein transduction domain derived from NH(2)-terminus of translationally controlled tumor protein (TCTP-PTD, MIIYRDLISH). Once inside the cell, the conjugated KLA exerts its...

journal_title：Biomaterials

authors： Kim HY,Kim S,Youn H,Chung JK,Shin DH,Lee K

更新日期：2011-08-01 00:00:00

abstract：:A "room-temperature" injection molding approach combined with particulate leaching (RTIM/PL) has been, for the first time, developed in this work to fabricate three-dimensional porous scaffolds composed of biodegradable polyesters for tissue engineering. In this approach, a "wet" composite of particulate/polymer/solve...

journal_title：Biomaterials

authors： Wu L,Jing D,Ding J

更新日期：2006-01-01 00:00:00

abstract：:Sodium alginate hydrogel, stabilized with gelatin, is a suitable, biologically inert matrix that can be used for encapsulating and 3D bioprinting of bone-related SaOS-2 cells. However, the cells, embedded in this matrix, remain in a non-proliferating state. Here we show that addition of an overlay onto the bioprinted ...

journal_title：Biomaterials

authors： Neufurth M,Wang X,Schröder HC,Feng Q,Diehl-Seifert B,Ziebart T,Steffen R,Wang S,Müller WEG

更新日期：2014-10-01 00:00:00

abstract：:Polymethyl methacrylate (PMMA) films were treated by oxygen plasma discharge followed by acrylic acid (AA) grafting. The amount of carboxyl groups introduced by the grafting of AA on to the film surfaces was in the range 0.47-9.48 mumol/cm2, depending on the pressure of the plasma chamber during the discharge treatmen...

journal_title：Biomaterials

authors： Kang IK,Kwon BK,Lee JH,Lee HB

更新日期：1993-08-01 00:00:00

abstract：:Angiogenesis plays a prominent role in cancer progression. Anti-angiogenic therapy therefore, either alone or in combination with conventional cytotoxic therapy, offers a promising therapeutic approach. Paclitaxel (PTX) is a widely-used potent cytotoxic drug that also exhibits anti-angiogenic effects at low doses. How...

journal_title：Biomaterials

authors： Eldar-Boock A,Miller K,Sanchis J,Lupu R,Vicent MJ,Satchi-Fainaro R

更新日期：2011-05-01 00:00:00

abstract：:We studied three different types of scaffolds, encapsulating bone morphogenetic protein-2 (BMP-2) plasmid, in terms of their performances in bone regeneration in nude mice. The plasmid was loaded into fibrous matrices in three different ways: coating of naked DNA (Group A) or DNA/chitosan nanoparticles (Group B) onto ...

journal_title：Biomaterials

authors： Nie H,Ho ML,Wang CK,Wang CH,Fu YC

更新日期：2009-02-01 00:00:00

abstract：:Nitric oxide (NO) possesses various functions in cardiovascular diseases; however, due to an extremely short half-life and low bioavailability, its therapeutic application is limited. In inflamed tissues, overproduced reactive oxygen species (ROS) rapidly react with the endogenous NO, reducing its bioavailability. Her...

journal_title：Biomaterials

authors： Vong LB,Bui TQ,Tomita T,Sakamoto H,Hiramatsu Y,Nagasaki Y

更新日期：2018-06-01 00:00:00

abstract：:Stem cell-based gene therapies, wherein stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential for cancer applications owing to their innate ability to home to tumors. However, traditional stem cell-based gene therapies are hampered by our current inability to control w...

journal_title：Biomaterials

authors： Yin PT,Shah S,Pasquale NJ,Garbuzenko OB,Minko T,Lee KB

更新日期：2016-03-01 00:00:00