Abstract：
:The induction of hepatic cytochrome P450 1A (CYP 1A) is an important step in the response to contaminants such as polycyclic aromatic hydrocarbons (PAHs), and has been used as a biomarker of exposure in fish. Several consensus response elements have been identified, including eight potential xenobiotic response elements (XREs) in the promoter region of the European flounder cytochrome P450 1A gene. However not all of these sequences are necessarily active. To help elucidate the molecular regulation of this important gene, site directed mutagenesis and dual-luciferase reporter gene assays were employed to characterize the consensus transcription factor binding sites of the CYP 1A 5' flanking region. Mutation of response elements situated -1103, -859, -709 and -172 bases upstream of the transcription start site reduced the induction to 2.75, 1.51, 3.25 and 3.05 fold, respectively, compared with the full-length promoter (4.0-fold induction) on exposure to the PAH 3-methylcholanthrene (3MC) (1.0 microM). These results indicate that four out of eight different XREs are functional in the control of CYP 1A in the flounder. The activity of these response elements adds to the evidence for considerable diversity in vertebrate CYP 1A regulation.
journal_name
Mar Environ Resjournal_title
Marine environmental researchauthors
Lewis N,Williams TD,Chipman Kdoi
10.1016/j.marenvres.2004.03.002keywords:
subject
Has Abstractpub_date
2004-08-01 00:00:00pages
101-5issue
2-5eissn
0141-1136issn
1879-0291pii
S0141-1136(04)00034-0journal_volume
58pub_type
杂志文章abstract：:Coral reef ecosystems are declining at an alarming rate. Increasing seawater temperatures and occurrence of extreme warming events can impair sexual reproduction in reef-building corals and inhibit the ability for coral communities to replenish and persist. Here, we investigated the role of photophysiology on the repr...
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journal_title：Marine environmental research
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2006.08.005
更新日期：2007-04-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2008.02.012
更新日期：2008-07-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
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更新日期：2006-03-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2009.04.001
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2012.10.012
更新日期：2013-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2020.104982
更新日期：2020-09-01 00:00:00
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journal_title：Marine environmental research
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journal_title：Marine environmental research
pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Marine environmental research
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2004.07.003
更新日期：2005-06-01 00:00:00
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pub_type： 杂志文章
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2003.08.002
更新日期：2004-05-01 00:00:00
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journal_title：Marine environmental research
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更新日期：2020-06-01 00:00:00
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journal_title：Marine environmental research
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更新日期：2019-02-01 00:00:00
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journal_title：Marine environmental research
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更新日期：2015-08-01 00:00:00
abstract：:Carbonyl reductase (CBR) is an enzyme involved in protection from oxidative stress. In rainbow trout (Oncorhynchus mykiss), the hepatic mRNA abundance of the two isoforms (A and B) is increased after exposure to treated sewage effluents, as well as after exposure with β-naphthoflavone (β-NF) and the pro-oxidant paraqu...
journal_title：Marine environmental research
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
