Domoic acid excretion in dungeness crabs, razor clams and mussels.

Abstract:

:Domoic acid (DA) is a neurotoxic amino acid produced by several marine algal species of the Pseudo-nitzschia (PN) genus. We studied the elimination of DA from hemolymph after intravascular (IV) injection in razor clams (Siliqua patula), mussels (Mytilus edulis) and Dungeness crabs (Cancer magister). Crabs were also injected with two other organic acids, dichloroacetic acid (DCAA) and kainic acid (KA). For IV dosing, hemolymph was repetitively sampled and DA concentrations measured by HPLC-UV. Toxicokinetic analysis of DA in crabs suggested most of the injected dose remained within hemolymph compartment with little extravascular distribution. This observation is in sharp contrast to results obtained from clams and mussels which exhibited similarly large apparent volumes of distribution despite large differences in overall clearance. These findings suggest fundamentally different storage and elimination processes are occurring for DA between bivalves and crabs.

journal_name

Mar Environ Res

authors

Schultz IR,Skillman A,Woodruff D

doi

10.1016/j.marenvres.2008.02.012

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

21-3

issue

1

eissn

0141-1136

issn

1879-0291

pii

S0141-1136(08)00028-7

journal_volume

66

pub_type

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