Abstract：
:The aim of this investigation was to test the hypothesis that fasting-induced augmented lysosomal autophagic turnover of cellular proteins and organelles will reduce potentially harmful lipofuscin (age-pigment) formation in cells by more effectively removing oxidatively damaged proteins. An animal model (marine snail--common periwinkle, Littorina littorea) was used to experimentally test this hypothesis. Snails were deprived of algal food for 7 days to induce an augmented autophagic response in their hepatopancreatic digestive cells (hepatocyte analogues). This treatment resulted in a 25% reduction in the cellular content of lipofuscin in the digestive cells of the fasting animals in comparison with snails fed ad libitum on green alga (Ulva lactuca). Similar findings have previously been observed in the digestive cells of marine mussels subjected to copper-induced oxidative stress. Additional measurements showed that fasting significantly increased cellular health based on lysosomal membrane stability, and reduced lipid peroxidation and lysosomal/cellular triglyceride. These findings support the hypothesis that fasting-induced augmented autophagic turnover of cellular proteins has an anti-oxidative cytoprotective effect by more effectively removing damaged proteins, resulting in a reduction in the formation of potentially harmful proteinaceous aggregates such as lipofuscin. The inference from this study is that autophagy is important in mediating hormesis. An increase was demonstrated in physiological complexity with fasting, using graph theory in a directed cell physiology network (digraph) model to integrate the various biomarkers. This was commensurate with increased health status, and supportive of the hormesis hypothesis. The potential role of enhanced autophagic lysosomal removal of damaged proteins in the evolutionary acquisition of stress tolerance in intertidal molluscs is discussed and parallels are drawn with the growing evidence for the involvement of autophagy in hormesis and anti-ageing processes.
journal_name
Mar Environ Resjournal_title
Marine environmental researchauthors
Moore MN,Shaw JP,Ferrar Adams DR,Viarengo Adoi
10.1016/j.marenvres.2015.04.001subject
Has Abstractpub_date
2015-06-01 00:00:00pages
35-44eissn
0141-1136issn
1879-0291pii
S0141-1136(15)00049-5journal_volume
107pub_type
杂志文章abstract：:The effects of a simulated spill of sunflower oil in salt marsh sediments were compared with an experiment with linseed oil. Sunflower and linseed oil penetrated the sediments at the same rates but different adsorption of the oils onto sediment particles resulted in the establishment of anaerobic conditions at shallow...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/S0141-1136(02)00309-4
更新日期：2003-09-01 00:00:00
abstract：:Oysters Crassostrea rhizophorae and Crassostrea gigas were kept for fourteen days at four sites in São José, SC, Brazil, chosen according to a sewage discharge contamination gradient. Enzymatic activities of CAT, GST, G6PDH and GR were evaluated in gills and digestive glands. Higher CAT activity was observed in tissue...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2008.02.057
更新日期：2008-07-01 00:00:00
abstract：:Multidrug resistance transporters (MDRs) are excellent candidates for molecular-level biomonitoring - they function in exporting xenobiotic compounds and their expression is inducible. However, currently available MDR sequence information from aquatic invertebrates is partial and mostly biased towards the conserved AT...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2006.04.007
更新日期：2006-07-01 00:00:00
abstract：:The protection provided by marine reserves directly depends on the short and long-term movement patterns of local organisms. Although there has been an increase in research assessing the behavioural patterns of fishes in reef-based habitats, there is still a paucity of studies addressing the benefits of marine protect...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2018.01.015
更新日期：2018-04-01 00:00:00
abstract：:Several genes normally induced by estradiol (E(2)) in female fish, those for vitellogenins (VTGs) and zona radiata proteins (ZRPs), are also inducible in males exposed to estrogenic chemicals. Male sheepshead minnows (SHM) were exposed to both E(2) and para-nonylphenol (NP), at several doses and times to determine a d...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2004.03.043
更新日期：2004-08-01 00:00:00
abstract：:The potential of eel (Anguilla anguilla) as a monitoring species for the Thames Estuary, UK, was examined. Hepatic cytochrome P4501A [7-ethoxyresorufin O-deethylase (EROD) activity] and blood vitellogenin (Western analysis) were investigated as biomarkers of exposure to, respectively, organic contaminants and to conta...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/s0141-1136(00)00060-x
更新日期：2000-07-01 00:00:00
abstract：:Oysters from the Pacific north-west coast contain high cadmium concentrations (greater than 13.5 microg g(-1) dry weight), which exceed consumer guidelines for international markets. Oysters are selective filter-feeders and attempts which have focused on suspended particulate matter (SPM) as a means to assess the impo...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2009.04.008
更新日期：2009-09-01 00:00:00
abstract：:Maritime traffic is one of many anthropogenic pressures threatening the marine environment. This study was specifically designed to investigate the relationship between vessels presence and cetacean sightings in the high sea areas of the Western Mediterranean Sea region. We recorded and compared the total number of ve...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2015.05.009
更新日期：2015-08-01 00:00:00
abstract：:Identifying and quantifying microplastic in marine samples can be facilitated by removing natural organic matter (NOM). Cellulosic material, like chitin, however, are a type of NOM that is resistant to chemical digestion, and difficult to eliminate from samples. To address this, a two-step digestion method was develop...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2020.105080
更新日期：2020-10-01 00:00:00
abstract：:In this study, new DNA markers were explored for the flounder Platichthys flesus. cDNA and genomic sequences of the genes encoding the glyceraldehyde-3-phosphate-deshydrogenase (GAPDH), the cytosolic creatine kinase (CK), the prostaglandin D synthase (PGDS) and the betaine homocysteine methyltransferase (BHMT) were ch...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2010.05.002
更新日期：2010-08-01 00:00:00
abstract：:Marine organisms that occur in urbanised bays can be exposed to low-level chronic pollution that results in sublethal changes to behavior or reproduction. The effects of low levels of copper on the reproductive success of a mobile invertebrate were assessed. Free living flatworms are common predators of bivalves and b...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2007.02.004
更新日期：2007-09-01 00:00:00
abstract：:Certain environmentally persistent compounds can adversely affect reproduction by acting as steroid hormone agonists or antagonists. The goal of the present study was to determine the developmental stage most susceptible to exogenous hormone (estradiol and testosterone) exposure using a small teleost model. In the fir...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/s0141-1136(00)00068-4
更新日期：2000-07-01 00:00:00
abstract：:Fish farming is an important source of organic matter input in coastal waters, which contributes to eutrophication. In this study, the macrofaunal benthic community was studied after the cessation of fish farming with the aim of improving our understanding of benthic succession and sediment recovery in a marine ecosys...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2006.05.006
更新日期：2006-12-01 00:00:00
abstract：:Eelpouts (Zoarces viviparus) sampled at surveillance stations during the fall of 2007 and spring 2008 in different Danish coastal areas, were studied for biomarkers of polycyclic aromatic hydrocarbons (PAHs) exposure and effects. Two analytical techniques, synchronous fluorescence spectrometry (SFS) and high-performan...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2011.09.005
更新日期：2012-04-01 00:00:00
abstract：:Habitat mapping is essential for the management and conservation of coastal marine habitats. However, accurate and up-to-date habitat maps are rarely available for the marine realm. In this study, we mapped the coastal marine habitats of >400 km of coastline in the north-western United Arab Emirates (UAE) using a comb...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2020.105095
更新日期：2020-10-01 00:00:00
abstract：:The presence and the development of imposex were investigated in the common whelk (Buccinum undatum) and the red whelk (Neptunea antiqua) from the open North Sea and the Skagerrak. Imposex development was related to levels of organotins in snails and in the fine fractions (< 63 microm) of the sediments they inhabit. T...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/s0141-1136(02)00217-9
更新日期：2003-04-01 00:00:00
abstract：:The aim of this study was to detect ecotoxicological effects of 0.1 μm polystyrene microbeads in marine organisms belonging to different trophic levels. MP build up, lethal and sub-lethal responses were investigated in the bacterium Vibrio anguillarum (culturability), in the green microalga Dunaliella tertiolecta (gro...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2018.09.023
更新日期：2018-10-01 00:00:00
abstract：:Nodularia spumigena is a nitrogen-fixing filamentous cyanobacteria in the Baltic Sea. Nodularin (NOD), the hepatotoxic peptide produced by this cyanobacterium, accumulates in the organisms from different trophic levels. In this paper, the effects of N. spumigena cell extract on the round goby (Neogobius melanostomus) ...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2018.05.019
更新日期：2018-09-01 00:00:00
abstract：:Nrf2 is a well-known transcription factor controlling a number of antioxidant defense-related genes, which is understudied in bivalves. In this study, oysters Crassostrea gigas were exposed for 24, 48 and 96 h to 10 or 30 μM tert-butylhydroquinone (tBHQ), a classic Nrf2 activator. At 96 h, a clear induction of GSH-rel...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2017.07.020
更新日期：2017-09-01 00:00:00
abstract：:The need to develop powerful tools to detect exposure and effects of POPs and emerging contaminants in Mediterranean cetaceans led us to develop a suite of sensitive non-lethal biomarkers in integument biopsies of free-ranging animals. In order to propose induction of CYP1A1 and CYP2B, detected by Western blot analysi...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2008.02.006
更新日期：2008-07-01 00:00:00
abstract：:Experiments have been undertaken exposing larval common shrimp (Crangon crangon) and lobster (Homarus gammarus) and adult copepods (Acartia tonsa) to the key stresses of entrainment within power-station cooling-water systems. The apparatus has enabled the testing of mechanical, thermal, chlorine and realistic pressure...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2003.08.002
更新日期：2004-05-01 00:00:00
abstract：:In the search for new environmental-friendly antifoulants for replace metallic biocides, 7-hydroxy-4-methylcoumarin was synthesized according to green chemistry procedures. This compound was characterized by current organic analysis and its antifouling properties were firstly evaluated on the bivalve Mytilus edulis pl...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2015.11.010
更新日期：2016-02-01 00:00:00
abstract：:Mummichogs, Fundulus heteroclitus, an estuarine fish with a relatively small home range found along the eastern coast of the United States are well-suited to monitoring contaminant effects, including those of polycyclic aromatic hydrocarbons (PAHs). One of the common PAHs in estuaries is pyrene. We report here on effo...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2003.11.001
更新日期：2004-06-01 00:00:00
abstract：:Dissolved organic matter (DOM) is comprised of a myriad of macromolecules with specific physical and chemical properties that may influence the bioavailability of hydrophobic pesticides to animals. This study was conducted to assess the role of various forms of DOM on the uptake and bioconcentration of the organophosp...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2004.10.001
更新日期：2005-07-01 00:00:00
abstract：:The conspicuous, red harpacticoid Metis holothuriae grows to a large size (∼600 μm length) and accounts for 29.51% of the numerical meiofaunal abundance within blooms of the toxic, benthic cyanobacterium Lyngbya majuscula. Despite this, the meiobenthic juvenile trumpeter whiting, Sillago maculata, consume M. holothuri...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2011.12.001
更新日期：2012-03-01 00:00:00
abstract：:The large majority of studies on the genotoxic hazard of PAHs polluted water widely applied the ENA assay as versatile tool in large number of wild and farmed aquatic species. Nuclear abnormalities are commonly considered to be a direct consequence of genotoxic lesions in DNA macromolecule, and such evaluation might b...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2014.04.003
更新日期：2014-09-01 00:00:00
abstract：:Coral reef ecosystems are declining at an alarming rate. Increasing seawater temperatures and occurrence of extreme warming events can impair sexual reproduction in reef-building corals and inhibit the ability for coral communities to replenish and persist. Here, we investigated the role of photophysiology on the repr...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2020.105200
更新日期：2021-01-01 00:00:00
abstract：:The deep-sea environment is a sink for a wide variety of contaminants including heavy metals and organic compounds of anthropogenic origin. Life history traits of many deep-water fish species including longevity and high trophic position may predispose them to contaminant exposure and subsequent induction of pathologi...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2015.02.004
更新日期：2015-05-01 00:00:00
abstract：:Direct responses to rising temperatures and ocean acidification are increasingly well known for many single species, yet recent reviews have highlighted the need for climate change research to consider a broader range of species, how stressors may interact, and how stressors may affect species interactions. The latter...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2018.09.026
更新日期：2018-11-01 00:00:00
abstract：:Organisms living in temperate and polar regions experience extensive seasonal changes in the physical and biotic environment, including temperature, insolation, and food availability, among other factors. Sessile intertidal organisms respond to such seasonal fluctuations largely through physiological and biochemical m...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2020.105088
更新日期：2020-10-01 00:00:00
