Abstract：
:Nrf2 is a well-known transcription factor controlling a number of antioxidant defense-related genes, which is understudied in bivalves. In this study, oysters Crassostrea gigas were exposed for 24, 48 and 96 h to 10 or 30 μM tert-butylhydroquinone (tBHQ), a classic Nrf2 activator. At 96 h, a clear induction of GSH-related antioxidant defenses was observed in gills of tBHQ-exposed animals, including GSH, glutathione S-transferase (GST), glutathione peroxidase (GPx) and glutathione reductase (GR). Unexpectedly, the activities of GST, GPx and GR were significantly decreased 24 h after tBHQ treatment, suggesting a possible inhibition, which was supported by in vitro experiments. GR mRNA (24 h) and protein levels (24 and 96 h) were increased by tBHQ treatment, confirming its induction, possibly by the Nrf2 pathway. The conserved domains at C. gigas Keap1 and Nrf2 proteins and the clear induction of GSH-related antioxidant defenses by tBHQ, a classical Nrf2 inducer, support the idea of a functional Nrf2/Keap1 pathway in bivalves. tBHQ also proved to be a tool to explore redox regulatory mechanisms in bivalves.
journal_name
Mar Environ Resjournal_title
Marine environmental researchauthors
Danielli NM,Trevisan R,Mello DF,Fischer K,Deconto VS,Bianchini A,Bainy ACD,Dafre ALdoi
10.1016/j.marenvres.2017.07.020subject
Has Abstractpub_date
2017-09-01 00:00:00pages
142-149eissn
0141-1136issn
1879-0291pii
S0141-1136(17)30139-3journal_volume
130pub_type
杂志文章abstract：:In aquatic organisms inhabiting polluted waters genes are activated to build an adaptive/compensatory defence against the possible effects of pollutants. Such responses can be used as biomarkers of exposure to chemical compounds, outlining the molecular mechanisms activated under specific pollution scenarios. With the...
journal_title：Marine environmental research
pub_type： 杂志文章
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journal_title：Marine environmental research
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journal_title：Marine environmental research
pub_type： 杂志文章
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/s0141-1136(00)00249-x
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2011.09.012
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2015.05.003
更新日期：2015-08-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2004.03.033
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2020.105080
更新日期：2020-10-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2005.11.004
更新日期：2006-05-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2020.105204
更新日期：2021-01-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2013.11.004
更新日期：2014-03-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2004.03.100
更新日期：2004-08-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2014.02.004
更新日期：2014-05-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章,评审
doi：10.1016/j.marenvres.2004.10.005
更新日期：2005-08-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2007.02.004
更新日期：2007-09-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
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journal_title：Marine environmental research
pub_type： 杂志文章,评审
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journal_title：Marine environmental research
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更新日期：2021-01-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2013.09.007
更新日期：2013-12-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/s0141-1136(02)00136-8
更新日期：2002-09-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2012.12.003
更新日期：2013-03-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2011.10.011
更新日期：2012-05-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
abstract：:Habitat mapping is essential for the management and conservation of coastal marine habitats. However, accurate and up-to-date habitat maps are rarely available for the marine realm. In this study, we mapped the coastal marine habitats of >400 km of coastline in the north-western United Arab Emirates (UAE) using a comb...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2020.105095
更新日期：2020-10-01 00:00:00
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journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2006.04.005
更新日期：2006-07-01 00:00:00
abstract：:Mercury (Hg) in Atlantic cod (Gadus morhua) is one of many parameters that are monitored through OSPAR's Joint Assessment and Monitoring Programme. Time series for cod in the Inner Oslofjord (Norway) go back to 1984. Until 2014, annual median Hg-concentrations in cod from the Inner Oslofjord showed both significant up...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/j.marenvres.2017.07.018
更新日期：2017-09-01 00:00:00
abstract：:Nonylphenol (NP) is a breakdown product of alkylphenol polyethoxylates (APEs), an important class of non-ionic surfactants that are widely used in many detergent formulations and plastic products for industrial and domestic use. A complex microbial degradation pattern, characterized by the formation of several metabol...
journal_title：Marine environmental research
pub_type： 杂志文章
doi：10.1016/s0141-1136(00)00081-7
更新日期：2000-07-01 00:00:00
