Heterogeneity of lipoteichoic acid detected by anion exchange chromatography.

Abstract:

:A complex polydispersity became apparent when the poly(glycerophosphate) lipoteichoic acid of Enterococcus faecalis was chromatographed on DEAE-Sephadex. The chain length varied between 13 and 33 glycerophosphate residues per lipid anchor. In parallel, the extent of chain glycosylation increased from 0.2 to 0.4 diglucosyl residues per glycerophosphate unit. Substitution with D-alanine ester showed a reverse distribution dropping with increasing chain length from 0.53 to 0.23 mol D-alanine per mol phosphorus. Variations in the fatty acid composition were also observed. The results extent and modify the current picture of lipoteichoic acid biosynthesis. They further suggest that during infection the mammalian organism may be confronted particularly with long-chain less hydrophobic molecular species.

journal_name

Arch Microbiol

journal_title

Archives of microbiology

authors

Leopold K,Fischer W

doi

10.1007/BF00249103

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

446-50

issue

5

eissn

0302-8933

issn

1432-072X

journal_volume

157

pub_type

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