Abstract：
:AAA+ proteins remodel target substrates in an ATP-dependent manner, an activity that is of central importance for a plethora of cellular processes. While sharing a similar hexameric structure AAA+ proteins must exhibit differences in substrate recognition to fulfil their diverse biological functions. Here we describe strategies of AAA+ proteins to ensure substrate specificity. AAA domains can directly mediate substrate recognition, however, in general extra domains, added to the core AAA domain, control substrate interaction. Such extra domains may either directly recognize substrates or serve as a platform for adaptor proteins, which transfer bound substrates to their AAA+ partner proteins. The positioning of adaptor proteins in substrate recognition can enable them to control the activity of their partner proteins by coupling AAA+ protein activation to substrate availability.
journal_name
J Struct Bioljournal_title
Journal of structural biologyauthors
Mogk A,Dougan D,Weibezahn J,Schlieker C,Turgay K,Bukau Bdoi
10.1016/j.jsb.2003.10.009keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
90-8issue
1-2eissn
1047-8477issn
1095-8657pii
S1047847703002223journal_volume
146pub_type
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