Induction of cytotoxic T lymphocytes by dendritic cells pulsed with murine leukemic cell RNA.

abstract：:Older patients with acute myeloid leukemia (AML) have poor outcomes, with median durations of complete remission lasting less than 1 year. Increased toxicity in older patients limits the delivery of standard consolidation therapies, such as allogeneic stem cell transplant or high-dose cytarabine. Azacitidine, a nucleo...

journal_title：American journal of hematology

authors： Griffin PT,Komrokji RS,De Castro CM,Rizzieri DA,Melchert M,List AF,Lancet JE

更新日期：2015-09-01 00:00:00

abstract：:Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by isolated overproduction of platelets, thrombohemorrhagic complications, and a median age of 50-60. When it occurs in younger patients, the incidence of complications has been reported to be quite low, with a good long-term prognosis. We r...

journal_title：American journal of hematology

authors： Millard FE,Hunter CS,Anderson M,Edelman MJ,Kosty MP,Luiken GA,Marino GG

更新日期：1990-01-01 00:00:00

abstract：:Hepcidin is a small defensin-like peptide whose production by hepatocytes is modulated in response to anemia, hypoxia, or inflammation. Hepcidin could also act as an indicator of functional iron deficiency in these patients. Cross-sectional study was performed to assess hepcidin correlations with renal function, iron ...

journal_title：American journal of hematology

authors： Malyszko J,Malyszko JS,Pawlak K,Mysliwiec M

更新日期：2006-11-01 00:00:00

abstract：:Karyotypic analysis at time of diagnosis has an important value in determining initial response to treatment, remission duration and overall survival (OS) in acute myeloid leukemia (AML). Less is known about its value before allogeneic hematopoietic cell transplantation (allo-HCT) in patients transplanted with active ...

journal_title：American journal of hematology

authors： Poiani M,Labopin M,Battipaglia G,Beelen DW,Tischer J,Finke J,Brecht A,Forcade E,Ganser A,Passweg JR,Labussiere-Wallet H,Yakoub-Agha I,Schäfer-Eckart K,Kroeger N,Guffroy B,Ruggeri A,Esteve J,Nagler A,Mohty M

更新日期：2021-01-01 00:00:00

abstract：:Transferrin-iron uptake by peripheral blood monocytes was studied in vitro to test the hypothesis that the relative paucity of mononuclear phagocyte iron loading in hereditary hemochromatosis results from a defect in uptake of iron from transferrin. Monocytes from nine control subjects and 17 patients with hemochromat...

journal_title：American journal of hematology

authors： Sizemore DJ,Bassett ML

更新日期：1984-05-01 00:00:00

abstract：:Leg ulcers are a well recognized complication of sickle cell disease that has been attributed to venous insufficiency. We studied 16 patients with sickle cell disease and active ulcers using venous pulse volume recordings and photoplethysmography (Doppler studies). Based on hemodynamic monitoring, all 16 patients exhi...

journal_title：American journal of hematology

authors： Billett HH,Patel Y,Rivers SP

更新日期：1991-06-01 00:00:00

abstract：:ASXL1 and SRSF2 mutations in AML are frequently found in patients with preexisting myeloid malignancies and are individually associated with poor outcomes. In this multi-institutional retrospective analysis, we assessed the genetic features and clinical outcomes of 43 patients with ASXL1mut SRSF2mut AML and compared o...

journal_title：American journal of hematology

authors： Richardson DR,Swoboda DM,Moore DT,Johnson SM,Chan O,Galeotti J,Esparza S,Hussaini MO,Van Deventer H,Foster MC,Coombs CC,Montgomery ND,Sallman DA,Zeidner JF

更新日期：2021-01-27 00:00:00

abstract：:In the current study, we investigated C/EBPA gene mutations and promoter hypermethylation in a series of 53 patients with CN-AML. In addition, we also analyzed two other frequent mutations (FLT3/ITD and NPM1) in these patients and correlated them with C/EBPA gene alterations. 13/53 patients were FLT3/ITD+/NPM1-, 11/53...

journal_title：American journal of hematology

authors： Lu Y,Chen W,Chen W,Stein A,Weiss LM,Huang Q

更新日期：2010-06-01 00:00:00

abstract：:Polycythemia vera (PCV) and multiple myeloma are both clonal disorders of hematopoietic stem cells. The simultaneous occurrence of these diseases in an individual patient is rare. A case of synchronous PCV and smoldering myeloma is presented and the literature is reviewed. The issues of clinical importance in this unu...

journal_title：American journal of hematology

authors： Fink L,Bauer F,Perry JJ

更新日期：1993-11-01 00:00:00

abstract：:Pentosan polysulfate is a low-molecular-weight sulfated polysaccharide used as an antithrombotic drug. We present two patients who developed thrombocytopenia and venous thrombosis during treatment with pentosan polysulfate. The relationship between pentosan polysulfate and thrombocytopenia is supported by platelet agg...

journal_title：American journal of hematology

authors： Tardy-Poncet B,Tardy B,Grelac F,Reynaud J,Mismetti P,Bertrand JC,Guyotat D

更新日期：1994-03-01 00:00:00

abstract：DISEASE OVERVIEW:Approximately one-fourth of primary cutaneous lymphomas are B-cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCD...

journal_title：American journal of hematology

authors： Hristov AC,Tejasvi T,Wilcox RA

更新日期：2020-08-20 00:00:00

abstract：:Substantial evidence exists indicating T cell abnormalities in chronic lymphocytic leukemia (CLL). There is also evidence that the T cell is an important source of burst promoting activity (BPA) for the peripheral blood (PB) erythroid burst forming unit (BFU-e). We studied the BPA of T cells and response of BFU-e in n...

journal_title：American journal of hematology

authors： Socinski MA,Ershler WB

更新日期：1984-02-01 00:00:00

abstract：:Quantification of sickle hemoglobin (HbS) in patients with sickle cell disease (SCD) undergoing hydroxyurea or chronic transfusion therapy is essential to monitoring the effectiveness of these therapies. The clinical monitoring of %HbS using conventional laboratory methods is limited by high per-test costs and long tu...

journal_title：American journal of hematology

authors： Piety NZ,Yang X,Lezzar D,George A,Shevkoplyas SS

更新日期：2015-06-01 00:00:00

abstract：:Polycythemia vera (PV) is associated with a high incidence of thrombosis. The association of apparent and secondary polycythemia with thrombosis is not clear. It was suggested that activation of the coagulation system contributes to thrombus formation in PV. However, the mechanism of activation is unknown. Monocytes g...

journal_title：American journal of hematology

authors： Kornberg A,Rahimi-Levene N,Yona R,Mor A,Rachmilewitz EA

更新日期：1997-09-01 00:00:00

abstract：:We describe 3 episodes of microangiopathic hemolytic anemia (MAHA) in 2 solid organ recipients under FK506 (tacrolimus) therapy. In both cases, discontinuation of FK506 and treatment with plasma exchange, fresh frozen plasma replacement, corticosteroids, aspirin, and dipyridamole led to resolution of MAHA. In one pati...

journal_title：American journal of hematology

authors： Mach-Pascual S,Samii K,Beris P

更新日期：1996-08-01 00:00:00

abstract：:Arsenic trioxide (As(2)O(3)) has been found effective in the treatment in the treatment of acute promyelocytic leukemia (APML). Most studies with As(2)O(3) involve patients with APML who have relapsed following standard therapy. Between January 1998 and July 2000, 14 patients were recruited for an ongoing trial of As(...

journal_title：American journal of hematology

authors： Mathews V,Balasubramanian P,Shaji RV,George B,Chandy M,Srivastava A

更新日期：2002-08-01 00:00:00

abstract：:Anthracyclines have contributed to a marked increase in survival in different types of cancer [1,2]. Unfortunately, they are associated with dose-dependent cardiotoxicity and heart failure (HF) [3–8]. Change to a weekly dosage schedule with slow infusions has been tested, a strategy that requires more frequent hospita...

journal_title：American journal of hematology

authors： Georgakopoulos P,Roussou P,Matsakas E,Karavidas A,Anagnostopoulos N,Marinakis T,Galanopoulos A,Georgiakodis F,Zimeras S,Kyriakidis M,Ahimastos A

更新日期：2010-11-01 00:00:00

abstract：:Intravenous anti-D immune globulin (anti-D IGIV) is indicated for the treatment of immune thrombocytopenic purpura (ITP) in nonsplenectomized patients who are Rh(D)-positive. Recent reports have described episodes of intravascular hemolysis (IVH) and acute renal failure (ARF) after anti-D IGIV. We report the first adu...

journal_title：American journal of hematology

authors： Chun NS,Savani B,Seder RH,Taplin ME

更新日期：2003-12-01 00:00:00

abstract：:We studied the growth of erythroid burst-forming units (BFU-E) and erythroid colony forming units (CFU-E) from bone marrow and blood in six patients with erythroleukemia. Five patients grew CFU-E, while BFU-E were found in the marrow of two and in the peripheral blood of only one patient. In all cases with colony grow...

journal_title：American journal of hematology

authors： Newcomb MM,Balducci L,Coleman MB,Steinberg MH

更新日期：1978-01-01 00:00:00

abstract：:Idiopathic thrombocytopenic purpura is an autoimmune disease which involves opsonization of platelets by autoantibodies directed against different surface glycoproteins, leading to their premature destruction by the reticuloendothelial system. Management of patients with refractory ITP is difficult. Recent studies hav...

journal_title：American journal of hematology

authors： Braendstrup P,Bjerrum OW,Nielsen OJ,Jensen BA,Clausen NT,Hansen PB,Andersen I,Schmidt K,Andersen TM,Peterslund NA,Birgens HS,Plesner T,Pedersen BB,Hasselbalch HC

更新日期：2005-04-01 00:00:00

abstract：:Production of abnormal hemoglobin (HbS) in sickle-cell disease (SCD) results in its polymerization in deoxygenated conditions and in sickled-RBC formation. Dense RBCs (DRBCs), defined as density >1.11 and characterized by increased rigidity are absent in normal AA subjects, but present at percentages that vary of a pa...

journal_title：American journal of hematology

authors： Di Liberto G,Kiger L,Marden MC,Boyer L,Poitrine FC,Conti M,Rakotoson MG,Habibi A,Khorgami S,Vingert B,Maitre B,Galacteros F,Pirenne F,Bartolucci P

更新日期：2016-10-01 00:00:00

abstract：:Liquid culture of the mononuclear fraction of the blood of marmosets without any added stimulator resulted in the appearance of megakaryocytes. These cells could not be identified by light microscopy or by indirect immunofluorescence using antiplatelet antiserum. Ultrastructural identification was made using platelet ...

journal_title：American journal of hematology

authors： Burstein SA,Breton-Gorius J,Harker LA

更新日期：1980-01-01 00:00:00

abstract：:We present a case of acquired von Willebrand syndrome (AVWS) due to a monoclonal gammopathy of undetermined significance. Initially this case was diagnosed as congenital von Willebrand disease (VWD); however, re-examination of the medical history rendered a congenital bleeding disorder unlikely. A normal plasma von Wi...

journal_title：American journal of hematology

authors： Eikenboom JC,Tjernberg P,Van Marion V,Heering KJ

更新日期：2007-01-01 00:00:00

abstract：:A rare association of congenital afibrinogenemia and hereditary protein C deficiency is described in a 37-year-old female who suffered from ischemic necrosis in the left first toe. The diagnosis of afibrinogenemia was assessed by the absence of fibrinogen in clotting and immunological assays. The diagnosis of heredita...

journal_title：American journal of hematology

authors： Hanano M,Takahashi H,Itoh M,Shibata A

更新日期：1992-09-01 00:00:00

abstract：:Fibrillar granules (FGs) represent neutrophilic primary granules containing clustered filaments. We investigated neutrophils in the bone marrow obtained from 17 patients with chronic myeloproliferative disorders (CMPD) by electron microscopy. FG-positive neutrophils were seen in 15 of the 17 CMPDs with varying frequen...

journal_title：American journal of hematology

authors： Takemori N,Hirai K,Onodera R,Saito N,Miyokawa N

更新日期：1994-11-01 00:00:00

abstract：:While evidence for measurable residual disease (MRD) is a harbinger of inferior outcome in acute myeloid leukemia (AML) patients referred for allogeneic stem cell transplantation (allo-SCT), the exact clinical trajectory of specific patient subsets in this clinical setting is undefined. Using a recently published prog...

journal_title：American journal of hematology

authors： Nagler A,Labopin M,Canaani J,Niittyvuopio R,Socié G,Kröger N,Itäla-Remes M,Yakoub-Agha I,Labussière-Wallet H,Gallego-Hernanz MP,Deconinck E,Chevallier P,Finke J,Esteve J,Mohty M

更新日期：2020-06-12 00:00:00

abstract：:Autologous 51Cr-platelet kinetic studies were performed in splenectomized mongrel dogs. Mean survival time of PRP-platelets was 5.4 +/- 1.5 (SD) days (n = 6). The curves, though slightly curvilinear, showed mostly a linear type of decay, denoting that platelet removal from the circulation is mainly determined by aging...

journal_title：American journal of hematology

authors： Mezzano D,Aranda E,Foradori A,Rodríguez S,Lira P

更新日期：1984-01-01 00:00:00

abstract：:Some patients suffering from malignancies may benefit of myeloablative chemotherapy followed by hematological reconstitution with autologous peripheral blood reinfusion. A quick evaluation of the number of hematopoietic progenitors present in leukapheresis blood samples is necessary to ensure the collection of a suffi...

journal_title：American journal of hematology

authors： Teixeira G,Lenormand B,Jean P,Fardoun D,Sumereau-Dassin E,Bastit D,Tilly H,Piguet H,Monconduit M,Vannier JP

更新日期：1992-03-01 00:00:00

abstract：:In this study, we further established the role of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta, tumor necrosis factor-alpha (TNF-alpha), and interferon-alpha (IFN-alpha) as regulators of proliferation of acute myeloid leukemia (AML) cells. AML cells from 8 of 15 patients incorporated high levels of 3H-thymidin...

journal_title：American journal of hematology

authors： Carter A,Silvian-Draxler I,Tatarsky I

更新日期：1992-08-01 00:00:00

abstract：:The occurrence of factor VIII inhibitors in non-hemophilic patients is a rare event with a potentially lethal outcome. Despite its infrequent occurrence, the association of this inhibitor with multiple autoimmune diseases is well recognized. We report the case of a patient with the recently described autoimmune lympho...

journal_title：American journal of hematology

authors： Fang BS,Sneller MC,Straus SE,Frenkel L,Dale JK,Rick ME

更新日期：2000-07-01 00:00:00