Abstract:
:OBJECTIVES: The aims of this review are to present research data about aerosoltherapy and to discuss the optimization of this form of drug administration.METHOD: Review of the literature, covering some of the most important studies about aerosoltherapy, inhaler devices, pharmacokinetics and pharmacodynamics of inhaled drugs.RESULTS: Factors that influence deposition pattern and pharmacokinetics of inhaled drugs are discussed, as well as how they can affect clinical efficacy. Positive and negative features of inhaler devices are compared; an attempt to establish dose equivalency of drug delivered by different devices is made.CONCLUSIONS: Different inhaler devices and different inhaling techniques produce different drug deposition patterns and clinical effects. So, those who deal with aerosoltherapy, including patients, must be well aware of all those issues, in order to achieve the best results.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Souza LSdoi
10.2223/jped.428keywords:
subject
Has Abstractpub_date
1998-05-01 00:00:00pages
189-204issue
3eissn
0021-7557issn
1678-4782journal_volume
74pub_type
杂志文章abstract:OBJECTIVE:Exposure to sunlight in childhood is often more intense than in adults. Literature data unequivocally show the association between this social behavior and the risk for developing malignant melanoma and non-melanoma skin cancer, even in adulthood. Furthermore, skin photoaging begins already in childhood throu...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/jped.2194
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To analyze calcium intake in adolescents according to sociodemographic variables, health-related behaviors, morbidities, and body mass index. METHODS:This was a cross-sectional population-based study, with a two-stage cluster sampling that used data from a survey conducted in Campinas, São Paulo, Brazil, bet...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2015.09.004
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the alterations of heart rate, blood pressure, psychological aspects and oxygen saturation after continuous fenoterol inhalation (0.5 mg/Kg) by children with severe acute asthma. METHODS:We studied 30 patients with severe acute asthma who were treated at the pediatric ward of Hospital Universitár...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the incidence of diarrheal disease (DD) and acute respiratory infection (ARI) in children undergoing supplementation of zinc and other micronutrients through the use of sprinkles, as well as their acceptance by these patients. METHOD:This was a randomized double-blinded clinical trial of 143 heal...
journal_title:Jornal de pediatria
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jped.2012.11.004
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To describe the antimicrobial activity of β-defensin-2 produced in the mammary gland and secreted in human breast milk. METHODS:The peptide production was performed by DNA cloning. β-defensin-2 levels were quantified in 61 colostrum samples and 39 mature milk samples from healthy donors, by an indirect enzym...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2014.05.006
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To analyze the trend in mortality due to diarrhea among children under 5 in the town of Osasco (SP), Brazil, between 1980 and 2000. METHODS:This is a descriptive observational study with two different designs, the first using individuals as the unit of study, and the other ecological, using groups of individ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1856
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To perform a bibliometric analysis of theses and dissertations on prematurity in the Capes database from 1987 to 2009. METHODS:This is a descriptive study that used the bibliometric approach for the production of indicators of scientific production. Operationally, the methodology was developed in four steps...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2232
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:The aim of this paper is to review existing literature on the subject and to report on and discuss a case of Marcus Gunn Phenomenon. DESCRIPTION:A five year-old female, otherwise a healthy patient, while still a few months old, was seen by a pediatrician who detected a disorder of the right eye, initially be...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:
更新日期:2004-05-01 00:00:00
abstract::OBJECTIVE: To present and discuss the indications, the endoscopic and histologic findings and the complications of upper digestive endoscopies carried out in children and adolescents.METHODS: We have done 228 endoscopies in pediatric patients with ages between 3 months to 19 years (x=5.7 y) during a period of 8 months...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.410
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of celiac disease and to describe the histological alterations, clinical manifestations, and conditions associated with a group of first-degree relatives of celiac disease patients in the municipality of Recife, Northeast Brazil. METHOD:The study was conducted in outpatient clinic...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2013
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To compare the effect of soy polysaccharide on fecal weight and humidity in growing rats in relation to cellulose and a Soy formula without dietary fiber. METHODS:Twelve, 21-day-old, Wistar male rats, were distributed into three groups and fed AIN-93G ration with varying amounts of dietary fiber: Polysacchar...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::OBJECTIVE: To present current concepts about the diagnosis of recurrent abdominal pain and to review the basis of the therapeutic approach for this disease in children and adolescents. METHODS: References were obtained from the Medline, from recent review articles, and from personal files. Books and dissertations were...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.150
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of pathologic gastroesophageal reflux in a group of regurgitant infants attended at Helena Moura Hospital, Recife, State of Pernambuco, Brazil. The clinical criteria employed were based on Rome II criteria. METHOD:The study design was transversal. The patients were all children of...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To review well-known aspects of exogenous surfactant therapy, and to discuss controversial points regarding the current state of research. SOURCES:Review of the literature, using Medline and Cochrane Database Library, in association with the authors' experience in relation to exogenous surfactant replacement...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.900
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of exclusive breastfeeding and introduction of cow's milk in the first year of life on the diagnosis of asthma, wheezing, and atopy in children aged 3 to 4 years. METHODS:This is a cohort study nested in a randomized field trial investigating the effectiveness of dietary guidelines dur...
journal_title:Jornal de pediatria
pub_type: 杂志文章,随机对照试验
doi:10.2223/JPED.2031
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:This article reviews the clinical and epidemiological aspects of anxiety disorders in youngsters, as well as current medical and psychological treatment strategies. The role of the neurobiological models possibly involved in the etiology of these disorders is also discussed. SOURCES OF DATA:MEDLINE search of...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/1166
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to identify the causes of congenital microcephaly in Rio Grande do Sul, a state in southern Brazil, where no ZIKV outbreak was detected, from December 2015 to December 2016, which was the period when ZIKV infection was at its peak in northeast Brazil. METHODS:This was a cross-sectio...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.05.013
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Cystic fibrosis diagnosis is dependent on the chloride ion concentration in the sweat test (≥60mEq/mL - recognized as the gold standard indicator for cystic fibrosis diagnosis). Moreover, the salivary glands express the CFTR protein in the same manner as sweat glands. Given this context, the objective was to ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.04.005
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To review the literature for clinical data on infants with allergic or eosinophilic colitis. DATA SOURCE:MEDLINE search of all indexes was performed using the words "colitis or proctocolitis and eosinophilic" or "colitis or proctocolitis and allergic" between 1966 and February of 2013. All articles that desc...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.1016/j.jped.2013.03.024
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To evaluate bone mineral density and bone mineral content of skeleton and lumbar spine of pre-pubertal children and to correlate results thus found with sex, bone age, body weight, height and insulin-like growth factor 1 serum level. METHODS:26 boys and 12 girls aged between 7 and 8 years old, students from ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.555
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:To present a new branch of scientific knowledge, known as the developmental origins of health and disease (DOHaD), covering its concepts, study methods and ethical considerations in addition to the prospects for this area of knowledge. SOURCES:A non-systematic review of the biomedical literature intended to ...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.1728
更新日期:2007-11-01 00:00:00
abstract::Epidemiologic principles and methods have been widely employed in clinical research. The purpose of this paper is to discuss basic epidemiological concepts applied to the investigation of the determinants of infant diseases. The theoretical framework outlines the hypothesis of the investigation. The design of the stud...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.742
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVE:To present an up-to-date and critical review regarding food allergies, focusing mainly on treatment and prevention. SOURCES:Review of published literature searched on MEDLINE database; those data which were the most up-to-date and representative were selected (2000-2006). The search included the European Soc...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.1587
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of salbutamol administration by metered-dose inhaler with a home-made spacer versus jet nebulizer in children with moderate wheezing attacks. MATERIAL AND METHODS:A randomized, single-blinded trial was performed with a convenience sample of children presenting wheezing. The child...
journal_title:Jornal de pediatria
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To investigate the immune response of preterm infants to hepatitis B vaccination. METHODS:Three doses of recombinant hepatitis B vaccine (5 micro g dose) were administered to 35 preterm and 21 full-term infants within 24 hours after birth and at one and six months of postnatal age. RESULTS:A protective anti...
journal_title:Jornal de pediatria
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::OBJECTIVE: To review the use of corticosteroids in the treatment of newborns with chronic lung disease, adrenal insufficiency and upper airway edema. SOURCES: Review of the available medical literature on the use of corticosteroids in newborns. SUMMARY OF THE FINDINGS: Although there is evidence of short-term clinical...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.216
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To study the etiology of exanthema cases, with or without fever, in children seen in the emergency room of a hospital located in a region where dengue is endemic. METHODS:Enrollment took place between 21/09/2001 and 20/09/2002 and included 95.9% (71/74) of children presenting with exanthema at the emergency ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1522
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:To present evidence-based recommendations for the use of antibiotics for the treatment of the most common acute respiratory infections (ARI) and the available information on the importance of this type of management. SOURCES:MEDLINE and LILACS databases, technical publications by international organizations...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.1548
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To analyze the evolution of pediatric patients chosen for hepatic transplantation. METHODS:A review was made of the clinical charts of the first 65 children and adolescents with chronic liver disease, aged 5 months to 19 years (X = 6.8%), chosen for liver transplantation during the period of August 1994 to M...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.511
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVE:to evaluate changes in the biochemical profile of children treated or being treated for moderate or severe stunting in a nutrition recovery and education center. METHODS:this was a retrospective longitudinal study of 263 children treated at this center between August of 2008 to August of 2011, aged 1 to 6 ye...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2013.12.007
更新日期:2014-07-01 00:00:00