Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia.

abstract：:The genotypic proportions for major histocompatibility complex loci, HLA-A and HLA-B, of progeny in families in 23 South Amerindian tribes in which segregation for homozygotes and heterozygotes could occur are examined. Overall, there is a large deficiency of homozygotes compared with Mendelian expectations (for HLA-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Black FL,Hedrick PW

更新日期：1997-11-11 00:00:00

abstract：:In the troposphere, methanol (CH3OH) is present ubiquitously and second in abundance among organic gases after methane. In the surface ocean, methanol represents a supply of energy and carbon for marine microbes. Here we report direct measurements of air-sea methanol transfer along a ∼10,000-km north-south transect of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang M,Nightingale PD,Beale R,Liss PS,Blomquist B,Fairall C

更新日期：2013-12-10 00:00:00

abstract：:Polymorphism may play an important role in speciation because new species could originate from the distinctive morphs observed in polymorphic populations. However, much remains to be understood about the process by which morphs found new species. To detail the steps of this mode of speciation, we studied the geographi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corl A,Davis AR,Kuchta SR,Sinervo B

更新日期：2010-03-02 00:00:00

abstract：:Nipah virus (NiV) and Hendra virus are the type species of the highly pathogenic paramyxovirus genus Henipavirus, which can cause severe respiratory disease and fatal encephalitis infections in humans, with case fatality rates approaching 75%. NiV contains two envelope glycoproteins, the receptor-binding G glycoprotei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu K,Rajashankar KR,Chan YP,Himanen JP,Broder CC,Nikolov DB

更新日期：2008-07-22 00:00:00

abstract：:The survival of motor neurons is controlled by multiple factors that regulate different aspects of their physiology. The identification of these factors is important because of their relationship to motor neuron disease. We investigate here whether Mullerian Inhibiting Substance (MIS) is a motor neuron survival factor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang PY,Koishi K,McGeachie AB,Kimber M,Maclaughlin DT,Donahoe PK,McLennan IS

更新日期：2005-11-08 00:00:00

abstract：:An exciton is an electron-hole pair bound by attractive Coulomb interaction. Short-lived excitons have been detected by a variety of experimental probes in numerous contexts. An excitonic insulator, a collective state of such excitons, has been more elusive. Here, thanks to Nernst measurements in pulsed magnetic field...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang J,Nie P,Li X,Zuo H,Fauqué B,Zhu Z,Behnia K

更新日期：2020-12-01 00:00:00

abstract：:The crystal structure of fructose-1,6-bisphosphatase (EC 3.1.3.11) complexed with fructose 6-phosphate, AMP, and Mg2+ has been solved by the molecular replacement method and refined at 2.5-A resolution to a R factor of 0.215, with root-mean-square deviations of 0.013 A and 3.5 degrees for bond lengths and bond angles,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ke HM,Zhang YP,Lipscomb WN

更新日期：1990-07-01 00:00:00

abstract：:Peanut or groundnut (Arachis hypogaea L.), a legume of South American origin, has high seed oil content (45-56%) and is a staple crop in semiarid tropical and subtropical regions, partially because of drought tolerance conferred by its geocarpic reproductive strategy. We present a draft genome of the peanut A-genome p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Li H,Pandey MK,Yang Q,Wang X,Garg V,Li H,Chi X,Doddamani D,Hong Y,Upadhyaya H,Guo H,Khan AW,Zhu F,Zhang X,Pan L,Pierce GJ,Zhou G,Krishnamohan KA,Chen M,Zhong N,Agarwal G,Li S,Chitikineni A,Zhang GQ

更新日期：2016-06-14 00:00:00

abstract：:Chicken erythrocyte nuclei have been labeled in the active regions of the chromosome by using the nick translation reaction. In this procedure, accessible areas of the genome are preferentially nicked by the action of pancreatic DNase I and subsequently labeled by using DNA polymerase I from Escherichia coli. These nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gazit B,Panet A,Cedar H

更新日期：1980-04-01 00:00:00

abstract：:Inhibition of human purine nucleoside phosphorylase (PNP) stops growth of activated T-cells and the formation of 6-oxypurine bases, making it a target for leukemia, autoimmune disorders, and gout. Four generations of ribocation transition-state mimics bound to PNP are structurally characterized. Immucillin-H (K*i(1/4)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho MC,Shi W,Rinaldo-Matthis A,Tyler PC,Evans GB,Clinch K,Almo SC,Schramm VL

更新日期：2010-03-16 00:00:00

abstract：:The TATA box-binding activity of transcription factor IID (TFIID) is autoinhibited by the N-terminal domain of the Drosophila TATA box-binding protein- (TBP) associated factor 230/yeast TBP-associated factor 145 subunit, which binds to the TATA box-binding domain of TBP by mimicking the TATA box structure. Here, we pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotani T,Banno K,Ikura M,Hinnebusch AG,Nakatani Y,Kawaichi M,Kokubo T

更新日期：2000-06-20 00:00:00

abstract：:In diabetes, the death of insulin-producing beta-cells by apoptosis leads to insulin deficiency. The lower prevalence of diabetes in females suggests that female sex steroids protect from beta-cell injury. Consistent with this hypothesis, 17beta-estradiol (estradiol) manifests antidiabetic actions in humans and rodent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le May C,Chu K,Hu M,Ortega CS,Simpson ER,Korach KS,Tsai MJ,Mauvais-Jarvis F

更新日期：2006-06-13 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) infection induces transcription of the chloramphenicol acetyltransferase (CAT) gene directed by the long terminal repeat (LTR) of human immunodeficiency virus (HIV) in both transiently and permanently transfected cells containing the HIV-LTR/CAT hybrid gene. To define the mechanism by wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mosca JD,Bednarik DP,Raj NB,Rosen CA,Sodroski JG,Haseltine WA,Hayward GS,Pitha PM

更新日期：1987-11-01 00:00:00

abstract：:Infection of Swiss mouse 3T3FL cells with a clonal isolate of Moloney leukemia virus (MLV-IC) resulted in virus progeny composed of at least three different murine helper oncornaviruses. Each entity was purified in appropriate cells by several sequential terminal dilution isolations and was grouwn to high titers. Besi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischinger PJ,Nomura S,Bolognesi DP

更新日期：1975-12-01 00:00:00

abstract：:PTEN is an important tumor-suppressor gene associated with many cancers. Through expression profiling of glioblastoma tissue samples and prostate cancer xenografts, we identified a molecular signature for loss of the PTEN tumor suppressor in glioblastoma and prostate tumors. The PTEN signature consists of a minimum of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehrian-Shai R,Chen CD,Shi T,Horvath S,Nelson SF,Reichardt JK,Sawyers CL

更新日期：2007-03-27 00:00:00

abstract：:Xenogeneic monoclonal antibodies were prepared to the murine interleukin 2 (IL-2)-dependent HT2 cell line. One rat IgM monoclonal antibody (7D4) was identified that inhibited proliferation of the HT2 cells and of IL-2-dependent CTLL cells in the presence of crude rat IL-2 as well as of purified human IL-2. The level o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malek TR,Robb RJ,Shevach EM

更新日期：1983-09-01 00:00:00

abstract：:Despite its theoretical prominence and sound principles, integrated pest management (IPM) continues to suffer from anemic adoption rates in developing countries. To shed light on the reasons, we surveyed the opinions of a large and diverse pool of IPM professionals and practitioners from 96 countries by using structur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parsa S,Morse S,Bonifacio A,Chancellor TC,Condori B,Crespo-Pérez V,Hobbs SL,Kroschel J,Ba MN,Rebaudo F,Sherwood SG,Vanek SJ,Faye E,Herrera MA,Dangles O

更新日期：2014-03-11 00:00:00

abstract：:Cadherin/catenin-based adhesions coordinate cellular growth, survival, migration, and differentiation within a tissue by mechanically anchoring cells to their neighbors. They also intersect with diverse signaling pathways in development and cancer. Although the adhesive functions of adherens junction proteins are well...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livshits G,Kobielak A,Fuchs E

更新日期：2012-03-27 00:00:00

abstract：:Urbanization and rural-urban migration are two factors driving global patterns of disease and mortality. There is significant concern about their potential impact on disease burden and the effectiveness of current control approaches. Few attempts have been made to increase our understanding of the relationship between...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian H,Hu S,Cazelles B,Chowell G,Gao L,Laine M,Li Y,Yang H,Li Y,Yang Q,Tong X,Huang R,Bjornstad ON,Xiao H,Stenseth NC

更新日期：2018-05-01 00:00:00

abstract：:Suspended aqueous aerosol droplets (<50 µm) are microreactors for many important atmospheric reactions. In droplets and other aquatic environments, pH is arguably the key parameter dictating chemical and biological processes. The nature of the droplet air/water interface has the potential to significantly alter drople...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei H,Vejerano EP,Leng W,Huang Q,Willner MR,Marr LC,Vikesland PJ

更新日期：2018-07-10 00:00:00

abstract：:The lateral neural plate border (NPB), the neural part of the vertebrate neural border, is composed of central nervous system (CNS) progenitors and peripheral nervous system (PNS) progenitors. In invertebrates, PNS progenitors are also juxtaposed to the lateral boundary of the CNS. Whether there are conserved molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Zhao D,Horie T,Chen G,Bao H,Chen S,Liu W,Horie R,Liang T,Dong B,Feng Q,Tao Q,Liu X

更新日期：2017-08-01 00:00:00

abstract：:Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron E,Pauling L

更新日期：1976-10-01 00:00:00

abstract：:The largest known DNA viruses infect Acanthamoeba and belong to two markedly different families. The Megaviridae exhibit pseudo-icosahedral virions up to 0.7 μm in diameter and adenine-thymine (AT)-rich genomes of up to 1.25 Mb encoding a thousand proteins. Like their Mimivirus prototype discovered 10 y ago, they enti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legendre M,Bartoli J,Shmakova L,Jeudy S,Labadie K,Adrait A,Lescot M,Poirot O,Bertaux L,Bruley C,Couté Y,Rivkina E,Abergel C,Claverie JM

更新日期：2014-03-18 00:00:00

abstract：:Signal transductions by the dual-function CXCR4 and CCR5 chemokine receptors/HIV type 1 (HIV-1) coreceptors were electrophysiologically monitored in Xenopus laevis oocytes that also coexpressed the viral receptor CD4 and a G protein-coupled inward-rectifying K+ channel (Kir 3.1). Large Kir 3.1-dependent currents gener...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madani N,Kozak SL,Kavanaugh MP,Kabat D

更新日期：1998-07-07 00:00:00

abstract：:Von Willebrand factor-binding protein (VWbp), secreted by Staphylococcus aureus, displays secondary structural homology to the 3-helix bundle, D1 and D2 domains of staphylocoagulase (SC), a potent conformational activator of the blood coagulation zymogen, prothrombin (ProT). In contrast to the classical proteolytic ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroh HK,Panizzi P,Bock PE

更新日期：2009-05-12 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery from replication arres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Park SH,Pantazides BG,Karpiuk O,Warren MD,Hardy CW,Duong DM,Park SJ,Kim HS,Vassilopoulos A,Seyfried NT,Johnsen SA,Gius D,Yu DS

更新日期：2013-08-13 00:00:00

abstract：:We recently found that the beta-adrenergic agonist 1-isoproterenol evokes a rapid (less than 5 min) Ca2+- and receptor-dependent stimulation of endocytosis, hexose transport, and amino acid transport in mouse renal cortex involving proximal tubule cells. This response is associated with increased Ca2+ fluxes and a mob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenig H,Goldstone AD,Lu CY

更新日期：1983-12-01 00:00:00

abstract：:A vitamin D(3) metabolite in intestine more polar than 25-hydroxy-vitamin D(3)(25-OH D(3)) has been detected by countercurrent distribution. The intestinal metabolite is found also after administration of labeled hydroxy D(3), indicating that it arises from vitamin D(3) via the intermediate 25-hydroxy derivative. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haussler MR,Boyce DW,Littledike ET,Rasmussen H

更新日期：1971-01-01 00:00:00

abstract：:In Trimenia moorei, an extant member of the ancient angiosperm clade Austrobaileyales, we found a remarkable pattern of female gametophyte (egg-producing structure) development that strikingly resembles that of pollen tubes and their intrasexual competition within the maternal pollen tube transmitting tissues of most ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachelier JB,Friedman WE

更新日期：2011-07-26 00:00:00

abstract：:Visualizing macromolecular complexes by single-particle electron microscopy (EM) entails stringent biochemical purification, specimen preparation, low-dose imaging, and 3D image reconstruction. Here, we introduce the "monolayer purification" method, which employs nickel-nitrilotriacetic acid (Ni-NTA) functionalized li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly DF,Dukovski D,Walz T

更新日期：2008-03-25 00:00:00