Abstract:
OBJECTIVE:The main concepts involved in the therapeutic management of intracranial hypertension are revisited, including pathophysiology, monitoring, the traditional approach, and also the presentation of recently proposed therapies. SOURCE OF DATA:The main medical literature data bases (especially Medline and Lilacs) were searched for articles published in the last 10 years, and traditional text books and dissertations focusing the subject were consulted. SUMMARY OF THE FINDINGS:Intracranial hypertension may be associated with several cerebral neurologic lesions from traumatic, infectious or metabolic origin, and in severe cases may represent an important factor for morbidity and mortality. Increases in intracranial pressure interfere with cerebral blood flow; in order to maintain an adequate cerebral perfusion pressure, it is necessary to both reduce and control intracranial hypertension and combat low blood pressure from the very beginning of treatment. Adequate monitoring is essential, and the main points addressed in conventional management include elevation of the head of bed to 30 degrees C, central positioning of the head, optimization of hypocapnia, perfect metabolic and hydro-electrolyte balance, sedation, anti-convulsive therapy, liquor drainage, and the use of barbiturics, mannitol and furosemide. New therapies currently under investigation include the use of dexanabinol, hypertonic saline solutions, moderate hypothermia, decompressive craniectomy, optimization of cerebral perfusion pressure, and reduction in cerebral microvasculature pressure (Lund therapy). CONCLUSIONS:The use of new therapies to effectively control intracranial hypertension, especially in cases that are refractory to the usual treatment, represent a promising scenario in the management of this problem.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Barbosa AP,Cabral SAdoi
10.2223/jped.1090keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
S139-48eissn
0021-7557issn
1678-4782journal_volume
79 Suppl 2pub_type
杂志文章,评审abstract:OBJECTIVE:To determine the prevalence of celiac disease in patients with myocarditis and dilated cardiomyopathy. METHODS:Fifty-six patients between 1 and 18 years old with dilated cardiomyopathy or myocarditis were evaluated and followed up at Instituto de Medicina Integral Professor Fernando Figueira. Patients with p...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2219
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:Using a wide and representative sample of adolescents from 37 countries, this study aimed to analyze how age changes adolescents' healthy lifestyle. METHODS:The study included 148,839 adolescents who participated in the Health Behavior in School-aged Children 2010 survey. A composite score of a healthy lifes...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.09.002
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To analyze the implementation of a protocol proposed by the Brazilian National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária - ANVISA) to improve sepsis diagnosis in very low birth weight newborns. METHODS:This was a prospective study that evaluated the implementation of a protocol inv...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2013.01.009
更新日期:2013-09-01 00:00:00
abstract::This prospective trial was realized in 371 children previously vaccinated with BCG in the first month of life in whom the Mantoux tuberculin test was done and read 48-72 hours afterwards. Among 371 BCG-vaccinated children, 106 (28.57%) were Mantoux reactive, 10 of whom with clinical tuberculosis. There was no statisti...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.728
更新日期:1994-03-01 00:00:00
abstract::OBJECTIVE: To review the use of corticosteroids in the treatment of newborns with chronic lung disease, adrenal insufficiency and upper airway edema. SOURCES: Review of the available medical literature on the use of corticosteroids in newborns. SUMMARY OF THE FINDINGS: Although there is evidence of short-term clinical...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.216
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:The objective of this review of genetic counseling (GC) is to describe the current concepts and philosophical and ethical principles accepted by the great majority of countries and recommended by the World Health Organization, the stages of the process, its results and the psychological impact that a genetic ...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/JPED.1782
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To measure the main risk factors associated with the occurrence of accidental injuries in children aged 4-5 years. METHODS:The study included a prospective cohort of children whose parents filled in a diary recording accidents and injuries during a period of one-month. The children represented a systematic s...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To compare the effect of soy polysaccharide on fecal weight and humidity in growing rats in relation to cellulose and a Soy formula without dietary fiber. METHODS:Twelve, 21-day-old, Wistar male rats, were distributed into three groups and fed AIN-93G ration with varying amounts of dietary fiber: Polysacchar...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence of metabolic syndrome-like symptoms in a population of preterm infants with very low birth weight (<1500g) at 2 years of corrected age and identify the occurrence of associated risk factors. METHODS:Cross-sectional study during a five-year period, including preterm infants born with ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2018.02.009
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To analyze the quality of life of children with stomas according to the children and mothers' point of view; to compare the results related to quality of life in both groups, and to verify the statistical associations between those aspects and children's demographic and clinical data. METHODS:After fulfillin...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To meta-analyze health-related quality of life in pediatric patients with chronic kidney disease in comparison to healthy patients according to the dimensions of the PedsQL instrument. SOURCES OF DATA:A systematic review was performed with meta-analysis for the mean difference in each of the health-related q...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.1016/j.jped.2020.10.013
更新日期:2020-12-17 00:00:00
abstract:OBJECTIVE:To report the results of open challenge tests performed in children fed with cow's milk-free diet. DESCRIPTION:Cross-sectional study evaluating cow's milk open challenge performed under supervision in a hospital setting during 2.5 hours and ambulatory follow-up for 30 days when no immediate reaction occurred...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1967
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To characterize the deaths of 193 children with sickle cell disease screened by a neonatal program from 1998 to 2012 and contrast the initial years with the final years. METHODS:Deaths were identified by active surveillance of children absent to scheduled appointments in Blood Bank Clinical Centers (Hemomina...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2014.08.006
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To describe the antimicrobial activity of β-defensin-2 produced in the mammary gland and secreted in human breast milk. METHODS:The peptide production was performed by DNA cloning. β-defensin-2 levels were quantified in 61 colostrum samples and 39 mature milk samples from healthy donors, by an indirect enzym...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2014.05.006
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To review the literature for clinical data on infants with allergic or eosinophilic colitis. DATA SOURCE:MEDLINE search of all indexes was performed using the words "colitis or proctocolitis and eosinophilic" or "colitis or proctocolitis and allergic" between 1966 and February of 2013. All articles that desc...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.1016/j.jped.2013.03.024
更新日期:2014-01-01 00:00:00
abstract::OBJECTIVES: To characterize primitive neuroectodermal tumor of the kidney as a differential diagnosis for Wilms tumor, and to emphasize the severity of the disease. METHODS: We report the case of a patient with a diagnosis of primitive neuroectodermal tumor of the kidney who underwent nephrectomy and complete tumor re...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.111
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To review the main causes of new bronchopulmonary dysplasia and the strategies utilized to decrease its incidence in extremely low birth weight infants. SOURCES OF DATA:For this review a MEDLINE search from 1966 to October 2004, the Cochrane Database, abstracts from the Society for Pediatric Research and rec...
journal_title:Jornal de pediatria
pub_type: 杂志文章,评审
doi:10.2223/1304
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. METHODS:Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160pmol/kg for four consecutive days. To evaluate th...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2015.08.012
更新日期:2016-05-01 00:00:00
abstract::OBJECTIVE: Evaluation of epidemiological, clinical and laboratory features of Plasmodium vivax malaria in children and adolescents. METHODS: This study was carried out in the Malaria Program of the Evandro Chagas Institute (Belém, Pará), from January 1995 to November 1996. 100 children and adolescents with the diagnos...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.295
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of celiac disease and to describe the histological alterations, clinical manifestations, and conditions associated with a group of first-degree relatives of celiac disease patients in the municipality of Recife, Northeast Brazil. METHOD:The study was conducted in outpatient clinic...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2013
更新日期:2010-07-01 00:00:00
abstract::OBJECTIVE: To assess the prevalence of prenatal exposure to cocaine in a sample of newborns using two methods: fluorescence polarization immunoassay and interview with the mother. METHODS: This cross-sectional study was carried out in a university teaching hospital. The population included all live births between Marc...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.277
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:We sought to describe the prevalence of microcephaly and to compare the different cutoff points established by the Brazilian Ministry of Health (MoH) at various times during a Zika virus epidemic. As a secondary aim, we investigated the possible etiology of the microcephaly. METHOD:This retrospective study u...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.1016/j.jped.2020.08.010
更新日期:2020-10-18 00:00:00
abstract:OBJECTIVE:To verify the concurrent validity and interobserver reliability of the Alberta Infant Motor Scale (AIMS) in premature infants followed-up at the outpatient clinic of Instituto Fernandes Figueira, Fundação Oswaldo Cruz (IFF/Fiocruz), in Rio de Janeiro, Brazil. METHODS:A total of 88 premature infants were enro...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1836
更新日期:2008-09-01 00:00:00
abstract::Spermatic cord torsion is an urologic emergency that requires urgent evaluation and possibly emergency surgical management. In a neonate it occurs during testicular descent and is usually due to an extravaginal torsion, where the testis and sperinatic cord twist. We present a case of intravaginal testicular torsion in...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract::OBJECTIVE: To present current concepts about the diagnosis of recurrent abdominal pain and to review the basis of the therapeutic approach for this disease in children and adolescents. METHODS: References were obtained from the Medline, from recent review articles, and from personal files. Books and dissertations were...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.150
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To verify children's acceptance of nasal fiber optic examination in a school setting and to evaluate hypertrophy of adenoid vegetation and to determine its prevalence in this population. METHOD:A survey was performed of a representative (n = 368) sample of school age children at elementary school (aged 6 to ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.1416
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:To identify and characterize respiratory viruses that infect children from daycare centers with symptoms of respiratory infection and to evaluate the association of clinical and epidemiological disease data with the identified virus. METHODS:We conducted a study between 2003 and 2005 in 176 children with re...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/JPED.2126
更新日期:2011-09-01 00:00:00
abstract::Phototherapy is a common procedure in the neonatal period. However there is great controversy in the literature about when and at which serum bilirubin levels phototherapy and exchange transfusion should be indicated. The aim of this paper is to review the literature and to suggest guidelines to help pediatricians in ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.776
更新日期:1995-07-01 00:00:00
abstract::In order to better understand the natural history of chronic functional constipation, a questionnaire was applied to 163 children and infants, before beginning standardized treatment. Median age (range) at start was 3 mo(0-108 mo) but age at arrival at the Pediatric Gastroenterology Unit was 53 mo(2-146 mo). In 62.4% ...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.688
更新日期:1994-09-01 00:00:00
abstract::OBJECTIVE: The aim of this article is to review and update the knowledge about sleep disorders in childhood. SOURCES: Normal sleep ontogenesis and therapeutics for the most prevalent sleep disorders were reviewed. The text was based on classical articles and books and on Medline (publications from 2000 and 2001) using...
journal_title:Jornal de pediatria
pub_type: 杂志文章
doi:10.2223/jped.852
更新日期:2002-07-01 00:00:00