Abstract:
AIM:The complete biological effects of chronic use of dehydroepiandrosterone (DHEA), reported as a weak androgen, are not completely understood. The aim of the present study is to evaluate the effects of chronic administration of DHEA on the spermatogenesis in rats. METHODS:Male Wistar rats, 4 months old, were selected for the study. The animals were divided into two groups. Group 1 (n = 9) received placebo (saline solution) 0.5 ml/day and Group 2 (n = 15) received DHEA 5 mg/kg/day. Both the groups received the respective treatments 5 days a week during 10 months. At the end of the exposure, the rats were sacrificed and the testes removed, weighed and processed for histologic analysis. Spermatogenesis was evaluated as the mean number of seminiferous tubules with and without spermatids in maturation phase in their lumen, in five random fields on the same slide. RESULTS:The median levels of serum total testosterone and dehydroepiandrosterone sulfate was measured in the two groups. Significant higher concentrations in total testosterone (2.06 +/- 0.4 vs. 0.80 +/- 0.2; p < 0.05) and DHEAS (222.1 +/- 41.5 vs. 2.0 +/- 0.3) were observed in the group treated with DHEA as compared to the control group. The mean weights of the right testes were 1.59 +/- 0.3 in group 1 and 1.58 +/- 0.2 g in group 2 (p > 0.05). These values for the left testes were 1.57 +/- 0.3 and 1.55 +/- 0.3 g, respectively (p > 0.05). The histologic analysis showed a mean of 13.5 +/- 1.5 and 12.8 +/- 1.8 seminiferous tubules per field in the groups 1 and 2, respectively (p > 0.05). The same analysis demonstrated that in the control group 0.06 +/- 0.1 of the tubules presented without spermatids in maturation phase and in the DHEA group this was observed in 0.22 +/- 1.2 of the tubules (p > 0.05). CONCLUSION:Chronic administration of DHEA in the present dose did not show any detectable effect on the quantitative and qualitative analyses of spermatogenesis in rats.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Gobbi D,Rhoden EL,Menti E,Lulhier F,Rhoden Cdoi
10.1023/a:1025918228851keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
119-22issue
1eissn
0301-1623issn
1573-2584journal_volume
35pub_type
杂志文章abstract:OBJECTIVE:To determine the prostate specific antigen (PSA) population standards of a cluster of Turkish men with no clinical evidence of prostate cancer. PATIENTS AND METHODS:We evaluated PSA values of the men who were living in a well-defined, rural district of Western Anatolia. Two hundred fifty-seven men agreed to ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-7976-y
更新日期:2005-01-01 00:00:00
abstract::Fifteen patients with urinary retention following rectal resection were examined urodynamically, including cystometry and simultaneous measurement of flow and pressure in the bladder and in the abdomen. Five patients suffered from bladder neck obstruction. This was in most cases put down to a preexisting prostatic enl...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081813
更新日期:1982-01-01 00:00:00
abstract::In the management of infertility, in case semen quality is found insufficient and could not be improved by medical means, handling the available spermatozoa in the most beneficial way has been aimed. Thus, artificial insemination with low quality semen has become a therapeutic alternative. In this study homologous art...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550148
更新日期:1996-01-01 00:00:00
abstract::Gonococcal infection of a penile prosthesis is a rare presentation of a common disease. Here we report two cases of penile prosthesis extrusion due to gonococcal infection. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/b:urol.0000034631.03070.9c
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:PSA is regarded as the best method in the follow-up of prostate carcinoma. After radical vesiculo-prostatectomy the prostate carcinoma seldom recurs at zero or nearly zero PSA levels. METHODS:The authors have used PSA since 1989 and they have found only one case where metastasis in the tibia came without an...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1007142910479
更新日期:2000-01-01 00:00:00
abstract::A 40-year-old man was referred to our hospital with gynecomastia and painless swelling of the right scrotum. Ultrasonography revealed a 15 x 10 mm mass with low echogenicity of the right testis. We performed right high orchiectomy. Histologically, Reinke's crystals and capsular invasion by tumor cells were found. Fina...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-6661-8
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:The present study aimed to evaluate the impact of a filmed research-based drama-Fit for Dialysis-and an exercise program on patients' physical activity and fitness outcomes. METHODS:Nineteen (10 at the intervention site, 9 at the control site) older patients with a medical diagnosis of hemodialysis-dependent e...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02745-y
更新日期:2021-01-02 00:00:00
abstract:PURPOSE:This study examined whether the laser-capture microdissection (LCM) method can achieve separation of urothelial cells from detrusor cells or superficial urothelial cells from intermediate/basal urothelial cells, using α-smooth muscle actin (SMA) and cytokeratin 20 (CK20). In addition, we investigated the change...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-015-0926-z
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Paediatric kidney transplantation has different aspects in adults in terms of underlying primary renal disease, surgical technique, perioperative care and graft prognosis. Significant urological problems are present in a high percentage of paediatric recipients. This study was undertaken to characterize paed...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550558
更新日期:1998-01-01 00:00:00
abstract:AIM:To determine the effectiveness of transdermal electromotive administration (TEA) of verapamil and dexamethasone in the treatment of Peyronie's disease (PD). METHOD:Totally, 51 patients with PD were prospectively included in the study. All patients were evaluated by history, subjective score scales, physical examin...
journal_title:International urology and nephrology
pub_type: 临床试验,杂志文章
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更新日期:2009-01-01 00:00:00
abstract::Foreign body on penis is usually put himself or by his female partner by adults for sexual gratification and in children as an innocent childish play. We have managed a 10 years shepherd who put on a bark of tree with successful outcome which is not being reported in literature. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1017565520257
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:We evaluated the efficacy and safety outcomes of endoscopic intradetrusor botulinum toxin A (BTA) injections for the treatment of children with neuropathic bladder (NB) and non-neuropathic bladder (NNB) with or without detrusor overactivity in a single centre with a retrospective analysis. METHODS:For the peri...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02185-3
更新日期:2019-08-01 00:00:00
abstract::We aimed to investigate whether high peripheral and cavernosal plasma levels of apolipoprotein-(a) [Lp (a)] is an indicator for vasculogenic erectile dysfunction. We determined Lp (a), total cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL) levels in peripheral and cavernosal blood in 39 patients ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550575
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the results and complications in 170 patients with symptomatic benign hyperplasia who underwent laser prostatectomy focusing on six month and long-term results. METHODS:A total of 170 patients underwent side firing Neodymium:Yag laser prostatectomy between January 1995 and February 2001 of whom ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1025948028530
更新日期:2003-01-01 00:00:00
abstract::A low body mass index (BMI) and serum albumin are associated with increased risk of mortality in patients with chronic kidney disease (CKD). The purpose of this study was to evaluate BMI and serum albumin as predictors of all-cause and cardiovascular (CV) mortality in hemodialysed (HD) patients. We describe the result...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9201-2
更新日期:2007-01-01 00:00:00
abstract::A study was carried out to verify the clinical usefulness of the elaborated method for the measurement of antistreptococcal antibody in revealing the streptococcal etiology of glomerulonephritis. In 158 patients with glomerulonephritis antistreptococcal antibody (ASA), circulating immune complexes (CIC) and haemolytic...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082387
更新日期:1982-01-01 00:00:00
abstract::Platelet count did not significantly decrease after charcoal haemoperfusion in patients with acute poisoning and significantly decreased during regular dialysis treatment. Adherent platelets and leucocytes were found on the surface of granules after haemoperfusion using a scanning electron microscope. Decreased platel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081940
更新日期:1981-01-01 00:00:00
abstract::Children with nephrotic syndrome (NS) are at risk for sinovenous and arterial thrombosis, uncommon but serious complications of the nephrotic syndrome. Multiple factors are involved in the hypercoagulable state of patients with NS, for instance, enhanced platelet reactivity and deficiency of antithrombin III due to ur...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-008-9434-8
更新日期:2009-01-01 00:00:00
abstract::Ganglioneuroblastoma is a common type of tumor in children, but is rarely seen in adults. We present here a case of adrenal ganglioneuroblastoma in a 59-year old man. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-004-0851-z
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:Supracostal superior calyceal access has been shown to be the most suitable approach for staghorn calculi, calculi in the upper ureter, and complex inferior calyceal calculi. It is a good choice for direct access for most of the intrarenal collecting system and upper ureter. The aim of this retrospective stud...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-011-9916-y
更新日期:2011-12-01 00:00:00
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journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02564772
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:The prevalence of progressive chronic kidney disease (CKD) in children and adults with spina bifida is considerable, rising, and entirely preventable. REMOVING THE CAUSE:PREVENTION OF SPINA BIFIDA: The best prevention of CKD in spina bifida is prevention of spina bifida itself throug...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-010-9894-5
更新日期:2012-06-01 00:00:00
abstract::Serum and urine levels of tumour necrosis factor (TNF) which is a lymphokine was measured in patients with genitourinary cancer (either prostatic, bladder or testicular carcinoma) in order to find out whether there were elevated levels of TNF in those patients and if it was related to disease status. Although the prel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549736
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Prolonged cold ischemia time (CIT) has been associated with inferior graft survival in kidney transplantation (KT). The aim of this study was to evaluate the impact of prolonged CIT on short- and long-term outcomes and to determine the possible ways to optimize the use of these organs. METHODS:All kidney tr...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0235-8
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:The development of a symptomatic lymphocele (SL) is a frequent postoperative surgical complication after kidney transplantation. It may lead to pain and discomfort and cause transplant malfunction or even secondary graft loss. A large cohort of renal recipients was investigated to identify the possible risk fac...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-019-02269-0
更新日期:2019-12-01 00:00:00
abstract::Investigating the reliability of using some clinical and laboratory parameters as long-term prognostic factors in properly selected patients for stress urinary surgery could help in the prediction of the long-term result in each case. Toward this goal 51 women were examined prospectively, after they were assessed by c...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02575219
更新日期:1995-01-01 00:00:00
abstract::To report a rare congenital anomaly of the genitourinary tract, renal dysplasia is associated with ipsilateral incomplete duplicated ectopic ureter and seminal vesicle cyst in an adult, successfully treated with robotic-assisted laparoscopic approach. ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-013-0412-4
更新日期:2013-06-01 00:00:00
abstract:AIM:The aim of the present study was to determine whether administration of zolpidem, a nonbenzodiazepine sedative-hypnotic agent, at night would improve the frequency of nocturia unresponsive to alpha-blocker monotherapy in men with lower urinary tract symptoms (LUTS). MATERIALS AND METHODS:The study inclusion criter...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9206-x
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to provide a comprehensive dataset of porcine urinary bladder smooth muscle properties. Particularly, the history dependence of force production, namely force depression (FD) following shortening and force enhancement (FE) following stretch, was analysed. During active micturi...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-016-1482-x
更新日期:2017-02-01 00:00:00
abstract::In a retrospective study of patients treated for germ cell tumours, the authors found seven patients with primary extragonadal tumours in the retroperitoneum. These tumours are, in terms of histology, identical with germ cell tumours of the testis. The disease manifests itself by pain in the kidney region, palpable ab...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549572
更新日期:1988-01-01 00:00:00