Abstract:
:We contend that powerful group studies can be conducted using magnetoencephalography (MEG), which can provide useful insights into the approximate distribution of the neural activity detected with MEG without requiring magnetic resonance imaging (MRI) for each participant. Instead, a participant's MRI is approximated with one chosen as a best match on the basis of the scalp surface from a database of available MRIs. Because large inter-individual variability in sulcal and gyral patterns is an inherent source of blurring in studies using grouped functional activity, the additional error introduced by this approximation procedure has little effect on the group results, and offers a sufficiently close approximation to that of the participants to yield a good indication of the true distribution of the grouped neural activity. T1-weighted MRIs of 28 adults were acquired in a variety of MR systems. An artificial functional image was prepared for each person in which eight 5 x 5 x 5 mm regions of brain activation were simulated. Spatial normalisation was applied to each image using transformations calculated using SPM99 with (1) the participant's actual MRI, and (2) the best matched MRI substituted from those of the other 27 participants. The distribution of distances between the locations of points using real and substituted MRIs had a modal value of 6 mm with 90% of cases falling below 12.5 mm. The effects of this approach on real grouped SAM source imaging of MEG data in a verbal fluency task are also shown. The distribution of MEG activity in the estimated average response is very similar to that produced when using the real MRIs.
journal_name
Hum Brain Mappjournal_title
Human brain mappingauthors
Holliday IE,Barnes GR,Hillebrand A,Singh KDdoi
10.1002/hbm.10133keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
142-7issue
3eissn
1065-9471issn
1097-0193journal_volume
20pub_type
杂志文章abstract::Neural dynamics leading to conscious sensory perception have remained enigmatic in despite of large interest. Human functional magnetic resonance imaging (fMRI) studies have revealed that a co-activation of sensory and frontoparietal areas is crucial for conscious sensory perception in the several second time-scale of...
journal_title:Human brain mapping
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journal_title:Human brain mapping
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1002/hbm.22342
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Human brain mapping
pub_type: 杂志文章
doi:10.1002/hbm.22092
更新日期:2013-10-01 00:00:00
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更新日期:2018-03-01 00:00:00