Circadian rhythms of locomotor activity in Drosophila.

Abstract:

:Drosophila is by far the most advanced model to understand the complex biochemical interactions upon which circadian clocks rely. Most of the genes that have been characterized so far were isolated through genetic screens using the locomotor activity rhythms of the adults as a circadian output. In addition, new techniques are available to deregulate gene expression in specific cells, allowing to analyze the growing number of developmental genes that also play a role as clock genes. However, one of the major challenges in circadian biology remains to properly interpret complex behavioral data and use them to fuel molecular models. This review tries to describe the problems that clockwatchers have to face when using Drosophila activity rhythms to understand the multiple facets of circadian function.

journal_name

Behav Processes

journal_title

Behavioural processes

authors

Klarsfeld A,Leloup JC,Rouyer F

doi

10.1016/s0376-6357(03)00133-5

keywords:

subject

Has Abstract

pub_date

2003-09-29 00:00:00

pages

161-175

issue

2

eissn

0376-6357

issn

1872-8308

pii

S0376635703001335

journal_volume

64

pub_type

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