Partial suppression of cell mediated immunity in chromoblastomycosis.

Abstract:

:The cellular immune response of 8 patients from the Brazilian Amazon region with chromoblastomycosis was analyzed. Primary immunological responses of patients were tested by contact sensitization to 2,4-dinitro-chlorobenzene (DNCB), or rejection of first set skin allografts. 2 of 8 patients were reactive to DNCB after sensitization, and skin allograft rejection occurred in an average of 14 days. Capacity of patients to mount recall immunological responses was measured by skin testing with two fungal antigens and three bacterial antigens. Delayed skin reaction to trichophytin and candida antigens was negative in the majority of the patients. However, reactivity to mycobacterial (tuberculin), and bacterial (staphylococcal, streptococcal) antigen was high, or only slightly diminished respectively. The data suggest that patients with chromoblastomycosis have suppressed nonspecific, cell mediated immunity for some antigens (skin allografts, DNCB, fungal antigens), while reactivity to bacterial and mycobacterial antigens is not impaired.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Fuchs J,Pecher S

doi

10.1007/BF00443936

keywords:

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

73-6

issue

2

eissn

0301-486X

issn

1573-0832

journal_volume

119

pub_type

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