Abstract:
:Twenty-six trichothecene mycotoxins produced by Fusarium sporotrichioides (MC-72083) and Fusarium sambucinum were screened for relative cytotoxicity in cultured baby hamster kidney (BHK-21) cells. The relative cytotoxicity was measured as LC100. The most cytotoxic trichothecenes were T-2 toxin (5 ng/ml) and the recently isolated 4-propanoyl HT-2 (5 ng/ml) and 3'-hydroxy T-2 toxin (5 ng/ml). T-2 tetraol (1 x 10(4) ng/ml), 8-beta-hydroxytrichothecene (1 x 10(4) ng/ml), sporotrichiol (2 x 10(4) ng/ml), 8-oxodiacetoxyscirpenol (6 x 10(4) ng/ml) and 8-acetyl T-2 tetraol (1 x 10(5) ng/ml) were the least toxic of the regular trichothecenes. None of the modified trichothecenes or the apotrichothecene were very cytotoxic: 8-beta-hydroxysambucoin (2 x 10(3) ng/ml), FS-1 (5 x 10(3) ng/ml), 8-alpha-hydroxysambucoin (8 x 10(4) ng/ml) and trichotriol (1 x 10(5) ng/ml). The modified trichothecenes, FS-2 and FS-3, were not toxic even at 1 x 10(5) ng/ml. The baby hamster kidney cell bioassay proved to be a very sensitive and reproducible means of screening new trichothecene mycotoxins for relative cytotoxicity.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Senter LH,Sanson DR,Corley DG,Tempesta MS,Rottinghaus AA,Rottinghaus GEdoi
10.1007/BF00442425subject
Has Abstractpub_date
1991-02-01 00:00:00pages
127-31issue
2eissn
0301-486Xissn
1573-0832journal_volume
113pub_type
杂志文章相关文献
MYCOPATHOLOGIA文献大全abstract::The diagnosis of invasive fungal infections (IFI) remains a challenge, particularly for diseases caused by filamentous fungi such as Aspergillus species. Unfortunately, many patients affected by these conditions are not identified before autopsy. Therefore, there is a need for new diagnostic methods for IFI. Galactoma...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-007-9010-2
更新日期:2007-04-01 00:00:00
abstract::A new fumonisin has been isolated from Fusarium moniliforme isolate MRC826 grown on corn. It was shown by NMR and mass spectrometry to be an isomer of fumonisin B2 that has free hydroxyl groups at C-3 and C-10 instead of the normal C-3 and C-5. This new fumonisin was detected in cultures of most isolates of F. monilif...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00497275
更新日期:1992-02-01 00:00:00
abstract::Cryptococcosis is currently the most common life threatening mycoses found in patients with the acquired immunodeficiency syndrome (AIDS). Extrapulmonary involvement is most frequently seen, especially in the central nervous system and skin. Clinical findings are non-specific, even in patients with meningitis. Thresho...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/BF00437205
更新日期:1991-06-01 00:00:00
abstract::Cryptococcus neoformans var. grubii and C. gattii were repeatedly isolated from decaying wood of trunk hollows in living trees growing in Jabalpur City in Central India. The isolation of C. gattii has been reported from decayed wood inside trunk hollow of Tamarindus indica (15.6%), Mangifera indica (2.2%), Pithecolobi...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-007-9039-2
更新日期:2007-10-01 00:00:00
abstract::Four new species of Penicillium Link ex Fries are described and illustrated. All of them but one have been isolated from the atmosphere in Madrid. Spain. They clearly differ from all species of the genus described so far and are, therefore, described and proposed as new taxa: Penicillium aurantio-flammiferum sp. nov.,...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00443048
更新日期:1980-08-29 00:00:00
abstract::Pulmonary aspergilloma is by no means uncommon in Malaysia. The lack of documentation of its occurrence in Malaysia, is mainly due to the lack of clinical awareness, and the absence of facilities for the proper diagnosis of the infection. ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00443517
更新日期:1986-03-01 00:00:00
abstract::Characterization of 62 isolates belonging to the genus Nocardia and related bacteria was obtained by using the API ZYM system. The difference in enzymatic profile should allow a relatively efficient, low-cost means to identify aerobic actinomycetes of clinical significance. ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00442770
更新日期:1990-04-01 00:00:00
abstract::Fumonisins are mycotoxins produced by Fusarium moniliforme, F. proliferatum, and related Fusarium species found on corn. They occur naturally in corn-based feeds and foods and are suspected human esophageal carcinogens. Fumonisin B1 (FB1), the most common homologue, causes the animal diseases associated with F. monili...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1006810916344
更新日期:1998-01-01 00:00:00
abstract::Rhodotorula species are increasingly being identified as a cause of fungal infection in the central nervous system, especially in patients with compromised immunity. The diagnosis could easily be missed due to low index of suspicion, as cryptococcus meningitis and cerebral toxoplasmosis are more common amongst immunoc...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-015-9879-0
更新日期:2015-08-01 00:00:00
abstract::Although abdominal cryptococcomas and visceral cryptococcal lymphadenitis as part of disseminated fungal infection have been reported mostly in HIV-infected patients, localized intra-abdominal involvement due to Cryptococcus gattii has not been previously described in non-HIV-infected patients. In general, a smaller p...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-011-9517-4
更新日期:2012-07-01 00:00:00
abstract::Sporotrichosis is a mycosis which in our country has been described as only producing cutaneous and subcutaneous infections; in other countries it has been reported as causing pulmonary, bone, joint and meningeal infections. Possibly the systemic form also occurs in Venezuela since, along with the causative agent, all...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00440950
更新日期:1984-04-15 00:00:00
abstract::Batrachochytrium dendrobatidis is a member of the phylum Chytridiomycota and the causative organism chytridiomycosis, a disease of amphibians associated with global population declines and mass mortality events. The organism targets keratin-forming epithelium in adult and larval amphibians, which suggests that keratin...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-008-9135-y
更新日期:2008-09-01 00:00:00
abstract::Four Norway rats (Rattus norvegicus) and one opossum (Didelphis virginiana) were surveyed for the presence of fungi. Eighteen different fungi were isolated from rat samples and six from the opossum, including Trichophyton mentagrophytes. Hair and skin scrapings from laboratory raised Norway rats, bedding and air from ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00625312
更新日期:1980-05-01 00:00:00
abstract::Sixteen fungal species were isolated from 182 specimens collected from four ruminants (buffalo, camel, cattle and sheep) in Southern Iraq. Fungi represented by five species of dermatophytes and eleven species of other fungi were screened for the activity of four enzymes: keratinase. proteinase, lipase and amylase. Ker...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1010854322655
更新日期:2001-01-01 00:00:00
abstract::We investigated phagocytosis and intracellular killing of clinical and environmental isolates of Aspergillus spp. by human monocyte-derived macrophages (MDMs). Serial pathogens such as Aspergillus fumigatus, Aspergillus flavus and Aspergillus terreus were examined with a microbiological assay. Phagocytosis for resting...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-007-9013-z
更新日期:2007-06-01 00:00:00
abstract::The aims of this study were to evaluate the epidemiology of nosocomial candidemia in a tertiary hospital in South Brazil and the in vitro antifungal susceptibility of isolates. Blood strains from 108 patients were identified by PCR-based method. Some 30.5 % of candidemia were caused by Candida tropicalis, 28.7 % were ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-014-9791-z
更新日期:2014-10-01 00:00:00
abstract::In a study of 450 Amazonian anurans, we isolated yeasts and yeast-like fungi from 54 animals (Bufo granulosus, B. marinus, Dendrophrynyscus sp., Hyla geographica, H. lanciformes, Ololygon rubra, Adenomera hylaedactyla, Eleutherodactylus fenestratus, Leptodactylus fuscus, L. ocellatus, L. pentadactylus). The internal o...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00442657
更新日期:1985-10-01 00:00:00
abstract::Chromoblastomycosis and phaeohyphomycosis represent two poles of a disease spectrum caused by melanized fungi. Veronaea botryosa belongs to a small genus of saprobic fungi that occasionally cause human infections. To date, 11 cases of V. botryosa-induced cutaneous phaeohyphomycosis have been actually reported since 19...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-015-9887-0
更新日期:2015-08-01 00:00:00
abstract::Pistachio nut samples taken during various stages of development from orchards in Iran, showed that contamination with fungi occurred mainly during the later stages of nut development. Members of the genera Aspergillus and Penicillium occurred most frequently. Of the Aspergilli, the species A. niger, A. flavus and A. ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00440685
更新日期:1979-05-31 00:00:00
abstract::We review here the advances in the understanding of the immunopathology of human paracoccidioidomycosis (PCM). Its investigation must take in account the intriguing natural history of the mycosis and its agent, providing clues to the mechanisms that lead to development of disease (unbalanced host-parasite relationship...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-007-9065-0
更新日期:2008-04-01 00:00:00
abstract::One of the most important forms of the occurrence of protothecosis is bovine mastitis. Studies on the "in vivo" and "in vitro" susceptibility to antimicrobials have shown that the microorganism is resistant to most of them. Looking for alternative treatments this study aimed to study the susceptibility to copper sulph...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1021313118632
更新日期:2002-01-01 00:00:00
abstract::The aim of this study was to detect antibodies against Paracoccidioides brasiliensis in dogs seropositive and seronegative for leishmaniasis. Sera from 836 dogs (449 positive and 387 negative to leishmaniasis) were analysed by ELISA and the immunodiffusion test using gp43 and exoantigen, respectively. The analysis of ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-006-0046-5
更新日期:2006-11-01 00:00:00
abstract::Fungi of the genus Alternaria are ubiquitous indoor and outdoor airborne agents, and individuals are daily exposed to their spores. Although its importance in human infections and, particularly in respiratory allergies, there are no studies of how Alternaria spp. spores interact with host cells. Our aim was to study t...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-019-00339-6
更新日期:2019-06-01 00:00:00
abstract::A comparative study was conducted with soybean material presenting symptoms of the Diaporthe/Phomopsis complex that was collected in two distant geographical regions of the world: Beltsville, MA, USA, and Vojvodina, Yugoslavia. Contrasting with earlier findings, great variability in the disease symptoms was observed, ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/A:1006849020432
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Broadly, there are three main categories in pulmonary aspergillosis: chronic forms of aspergillosis; allergic bronchopulmonary aspergillosis; and invasive aspergillosis (IPA). IPA has been further subdivided into angioinvasive and airway-invasive aspergillosis. Aspergillus overlap syndromes is defined as the...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-017-0212-y
更新日期:2018-04-01 00:00:00
abstract::Invasive aspergillosis can be difficult to diagnose, and early recognition and initiation of therapy is imperative for improving patient outcomes. A case of invasive Aspergillus laryngotracheobronchitis is presented here with a review of the relevant literature. A 58-year-old male undergoing treatment for CNS lymphoma...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-017-0123-y
更新日期:2017-08-01 00:00:00
abstract::Phoma herbarum has been associated with two outbreaks of systemic mycosis in hatchery-reared chinook salmon (Oncorhynchus tshawytscha) fingerlings. Affected fish exhibited abnormal swimming behavior, exophthalmia, multiple rounded areas of muscle softening, protruded hemorrhagic vents, and abdominal swelling. In all a...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-006-0084-z
更新日期:2007-01-01 00:00:00
abstract::The effect of increased temperature during transportation of clinical dermatophyte specimens was investigated. Recovery rates from untransported specimens cultured at dermatologists' offices and from duplicate transported specimens were compared. During the months of hot weather specimens could be exposed intermittent...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00625310
更新日期:1980-05-01 00:00:00
abstract::The susceptibility of 21 strains of Aspergillus (11 of A. fumigatus, 8 of A, niger, and 2 of A. flavus) isolated from human pathologic specimens to Amphotericin B and Miconazole has been comparatively studied. Determination of the minimal inhibitory concentration of both drugs in a liquid medium showed a noticeably va...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00576365
更新日期:1978-11-10 00:00:00
abstract::Mucormycosis is usually an invasive mycotic disease caused by fungi in the class mucormycetes. Here we report a case of cutaneous mucormycosis due to Lichtheimia ramosa in a 20-year-old female patient with burn injuries. She was admitted to the hospital with accidental flame burns covering 60 % total burn surface area...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-014-9805-x
更新日期:2014-10-01 00:00:00