Abstract:
:The aim of the present study was to ascertain whether cell-mediated immunity (CMI) is induced in animals by vaccination with Candida albicans ribosomes. Delayed type hypersensitivity (DTH) was detected in vivo in ribosome-vaccinated mice and guinea pigs by the footpad swelling and skin tests, respectively. The observed DTH was similar to that induced by live C. albicans organisms. A lymphocyte transformation assay was used for in vitro detection of CMI. The tritiated thymidine incorporation assays revealed that spleen lymphocytes from mice immunized with C. albicans ribosomes were stimulated by the ribosomal antigen. The findings establish that C. albicans ribosomes are able to induce CMI in experimental animals.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Levy R,Segal E,Eylan E,Barr-Nea Ldoi
10.1007/BF00437023subject
Has Abstractpub_date
1983-11-25 00:00:00pages
161-8issue
3eissn
0301-486Xissn
1573-0832journal_volume
83pub_type
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