Abstract:
:Water-soluble components of a nephrotoxic isolate of Penicillium aurantiogriseum have been fractionated by sequential ion-exchange, size-exclusion gel filtration, reverse-phase silica chromatography and HPLC. Nephrotoxicity in the rat was confined to a size-exclusion fraction approximating to 1,500 daltons, which also inhibited DNA synthesis in cultured kidney cells. The more sensitive in vitro assay allowed toxicity to be followed to a sub-fraction from gradient-elution HPLC which in further HPLC resolved into a small group of glycopeptides. Recent Yugoslavian P. aurantiogriseum isolates, from a village in which the idiopathic human disease Balkan Nephropathy is hyperendemic, elicited a similar nephropathology and were acutely cytotoxic, reinforcing a need to regard this novel Penicillium nephrotoxin as a potential factor in human nephropathy.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Yeulet SE,Mantle PG,Rudge MS,Greig JBdoi
10.1007/BF00436248subject
Has Abstractpub_date
1988-04-01 00:00:00pages
21-30issue
1eissn
0301-486Xissn
1573-0832journal_volume
102pub_type
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