Abstract:
:We describe the case of a patient with a T-lymphoblastic lymphoma whose disseminated mucormycosis was diagnosed with delay, and we address the diagnostic and therapeutic decision-making process and review the diagnostic workup of patients with potential IFD. The diagnosis was delayed despite a suggestive radiological presentation of the patient's pulmonary lesion. The uncommon risk profile (T-lymphoblastic lymphoma, short neutropenic phases) wrongly led to a low level of suspicion. The diagnosis was also hampered by the lack of indirect markers for infections caused by Mucorales, the low sensitivity of both fungal culture and panfungal PCR, and the limited availability of species-specific PCR. A high level of suspicion of IFD is needed, and aggressive diagnostic procedures should be promptly initiated even in apparently low-risk patients with uncommon presentations. The extent of the analytical workup should be decided on a case-by-case base. Diagnostic tests such as the galactomannan and β-D-glucan test and/or PCR on biological material followed by sequencing should be chosen according to their availability and after evaluation of their specificity and sensitivity. In high-risk patients, preemptive therapy with a broad-spectrum mould-active antifungal agent should be started before definitive diagnostic findings become available.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Zimmerli S,Bialek R,Blau IW,Christe A,Lass-Flörl C,Presterl Edoi
10.1007/s11046-016-0010-ysubject
Has Abstractpub_date
2016-08-01 00:00:00pages
561-6issue
7-8eissn
0301-486Xissn
1573-0832pii
10.1007/s11046-016-0010-yjournal_volume
181pub_type
杂志文章,评审相关文献
MYCOPATHOLOGIA文献大全abstract::A case of bursitis due to Prototheca wickerhamii is briefly reported. In histological sections the organism stained well with fungal stains, grey with silver methanamine and red with periodic acid Schiff reagent. This unicellular achlorophyllous alga was studied on common laboratory media. The characterization of the ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00443013
更新日期:1981-01-30 00:00:00
abstract::This case report discusses a patient with sickle cell disease who presented with fungemia from Pichia anomala (teleomorph: Candida pelliculosa). The organism was identified as P. anomala by MALDI-TOF VITEK mass spectrometry and VITEK 2 yeast identification card. Pichia anomala should be considered in sickle cell patie...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-013-9677-5
更新日期:2013-10-01 00:00:00
abstract::The incidence of candidiasis in 125 symptomless, non-gravid women in Ile-Ife State Hospital, Ile-Ife, Oyo-State of Nigeria was determined by either microscopic observation or cultural methods. Among the three techniques investigated, the cultural method had the highest recovery rate with 60% of the cultures from 125 p...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF01837192
更新日期:1982-09-17 00:00:00
abstract::Sixty-four species and 2 varieties which belong to nineteen genera of fungi were identified from 40 peanut seed samples collected from different places in Egypt by using a dilution-plate method on glucose-Czapek's medium. The most frequent genera were Aspergillus (21 species & 2 varieties), Penicillium (16 species) an...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00437651
更新日期:1987-06-01 00:00:00
abstract::Coccidioidomycosis is a common infection in the desert southwestern USA; approximately 3 % of healthy persons in Arizona alone become infected annually. Coccidioidomycosis may be severe in immunocompromised persons, but experience among patients with solid organ cancer has not been fully described. Therefore, we aimed...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-016-0044-1
更新日期:2016-12-01 00:00:00
abstract::An intracellular beta-hemolysin capable of lysing human, sheep and cow erythrocytes but not cells from some other animals was isolated from the cell walls of the three developmental cell-forms of Nocardia asteroides and characterised. The spherical cell-forms contained the highest amounts of the hemolysin (100 h.u./mg...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00436319
更新日期:1986-07-01 00:00:00
abstract::This paper describes four new cases of lymphomas, two Hodgkin lymphomas and two non-Hodgkin lymphomas in patients with paracoccidioidomycosis. All had mycosis diagnosed before lymphomas with Paracoccidioides brasiliensis demonstrated in several lymph nodes, as seen in the disseminated form of the disease. When lymphom...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-014-9851-4
更新日期:2015-04-01 00:00:00
abstract::Until the present decade, no studies had been conducted in Puerto Rico on the saprophytic distribution and variety of Cryptococcus neoformans. Samples (522) of pigeon droppings from 14 western towns were tested for the presence of C. neoformans. The yeast was recovered from 24.7% (129 isolates) of the samples, represe...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00443058
更新日期:1989-06-01 00:00:00
abstract::Melanin is a complex polymer which is secreted outside or constitutes the structure of fungal cell wall. It is considered as an important virulence factor in opportunistic pathogenic fungi. In this study, one albino mutant (CBS 125149) was generated from a parent meristematic mutant (CBS 122845) of Fonsecaea monophora...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-012-9588-x
更新日期:2013-06-01 00:00:00
abstract::We investigated the antifungal susceptibility profiles of 207 independent Candida albicans strains isolated from patients with vulvovaginal candidiasis (VVC) in Xinjiang Province of China. Using CLSI M27-A3 and M27-S4 guidelines, anidulafungin and micafungin were the most active drugs against C. albicans showing an MI...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-018-0305-2
更新日期:2019-06-01 00:00:00
abstract::Malbranchea gypsea IMI 338,168 isolated from the soils of Keoladeo National Park, Bharatpur was studied for its ability to produce exocellular proteases on glucose-gelatin medium at pH 7; 28 degrees C. The fungus was observed to be a potent producer of such enzymes. Protease production was optimal at 15 days of incuba...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1006968600404
更新日期:1998-01-01 00:00:00
abstract::A new fumonisin has been isolated from Fusarium moniliforme isolate MRC826 grown on corn. It was shown by NMR and mass spectrometry to be an isomer of fumonisin B2 that has free hydroxyl groups at C-3 and C-10 instead of the normal C-3 and C-5. This new fumonisin was detected in cultures of most isolates of F. monilif...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00497275
更新日期:1992-02-01 00:00:00
abstract::We have isolated two DNA fragments from Sporothrix schenckii. These fragments were nonspecifically amplified from the whole-cell DNA using polymerase chain reaction (PCR) primers originally designed in the gene encoding heat shock protein 70 of Mycobacterium leprae. Reverse transcription PCR demonstrated that the smal...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1006999508574
更新日期:1998-01-01 00:00:00
abstract::Adult CBA mice showed considerably greater resistance to experimental infection with Aspergillus fumigatus than young animals of the same strain (P less than 0.01). Furthermore, in contrast with the young mice, the susceptibility of the adults was only moderately increased by treatment with cortico-steroids. On the ot...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00490376
更新日期:1977-02-18 00:00:00
abstract::A systematic study on autolysis of the cell walls of fungi has been made on Neurospora crassa, Botrytis cinerea, Polystictus versicolor, Aspergillus nidulans, Schizophyllum commune, Aspergillus niger, and Mucor mucedo. During autolysis each fungus produces the necessary lytic enzymes for its autodegradation. From auto...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00437577
更新日期:1982-12-27 00:00:00
abstract::A survey on rhinosporidiosis in animals was conducted in Kanyakumari (K.K.) district of Tamil Nadu, India. Among 103 animals (40 bullocks, 45 cows, 15 heifers, 2 bulls and a buffalo), 19 (9 bullocks, 8 cows, 1 heifer and a she-buffalo) were found to be infected with Rhinosporidium seeberi. The study revealed the endem...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00769564
更新日期:1987-10-01 00:00:00
abstract::Clearance of cryptococcal polysaccharide (CP) from tissues and body fluids of nonimmune mice was studied. Mice were injected intravenously only with one mg of purified CP, and serum, urine and tissues were obtained from each animal at various intervals for a period of 84 days. Tissue extracts, serum and urine were tes...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00436580
更新日期:1982-04-23 00:00:00
abstract::Hylastes ater and Hylurgus ligniperda are introduced pests of re-established Pinus radiata in New Zealand. Both species breed under the bark of stumps in recently harvested areas. Adult maturation feeding on pine seedlings planted in adjacent areas can significantly impact seedling growth, and in severe cases seedling...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-009-9229-1
更新日期:2010-01-01 00:00:00
abstract::Fungal infection is a severe problem in children suffering from cancer. We report a case of a four-year-old girl who was diagnosed with acute lymphoblastic leukemia and multiple Aspergillus niger abscesses at the induction phase of the treatment. She was treated with granulocyte transfusions, liposomal amphotericin B ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-012-9563-6
更新日期:2012-12-01 00:00:00
abstract::Chronic exposure to moniliformin results in the development of myocardial hypertrophy and degeneration. The cause of this hypertrophy is unknown. However, moniliformin-induced hypoxia or altered function of cardiac pyruvate dehydrogenase, rather than direct cardiostimulation have been proposed as potential mechanisms....
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00439122
更新日期:1996-01-01 00:00:00
abstract::Liposomes expressing external antibody specific for Candida albicans and encapsulating amphotericin B were developed and characterized in this study. Antibody was first modified by the covalent attachment of palmitic acid residues. Liposomes were produced by reverse-phase evaporation and modified antibody was incorpor...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00455667
更新日期:1988-01-01 00:00:00
abstract::We analyze the prognostic potential of (1 → 3)-β-D-glucan (BG) levels in predicting clinical outcomes in patients with invasive fungal infections, on a population undergoing 253 episodes (177 with positive and 76 with negative outcome). Using linear regression analysis, we assessed the prognostic potential of kinetica...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-018-0282-5
更新日期:2019-02-01 00:00:00
abstract::The application of a modified colorimetric bioassay for the evaluation of the biological effects of mycotoxins is reported. Using three different monolayer cell lines (swine kidney, Madin Darby canine kidney, HeLa) the influence of nine different mycotoxins on the cellular methylthiazoltetrazolium (MTT)-cleavage activ...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF01138479
更新日期:1994-12-01 00:00:00
abstract::Green cocoa pod husk agar (GCPA), ripe cocoa pod husk agar (RCPA), green cocoa bean agar (GCBA), ripe cocoa bean agar (RCBA), green cocoa mucilage agar (GCMA) and ripe cocoa mucilage agar (RCMA) were prepared and assessd for their clarity and for potential to support mycelial growth and sporulation of P. palmivora. Oa...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1020415109308
更新日期:2002-01-01 00:00:00
abstract::The objectives of this study were to evaluate the fumonisin production by 16 F. verticillioides strains on corn cultures and the effect of quintozene and fludioxonil + metalaxyl-M fungicides on "in vitro" mycelial growth on agar. In addition, the effect of fludioxonil + metalaxyl-M on fumonisin production in defined l...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-010-9339-9
更新日期:2011-01-01 00:00:00
abstract::In a survey of 296 sylvatic animals captured from virgin forests in the north-eastern and south-western Amazon of Brazil, Histoplasma capsulatum was isolated, via the indirect hamster inoculation method, from the liver and spleen of four common opossums Didelphis marsupialis and two pacas Agouti paca. The infected ani...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00447026
更新日期:1985-03-01 00:00:00
abstract::The effect of a sub-inhibitory concentration of chlorhexidine on lipid and sterol composition of Candida albicans was investigated. The total lipid content of this yeast grown in the presence of chlorhexidine was reduced whilst the total sterol content was increased compared with control-grown cells. Lipids and sterol...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1023/a:1006852207366
更新日期:1997-01-01 00:00:00
abstract::Ustilago, a common fungal parasite of grains, is infrequently isolated as a pathogen in humans. We describe a case of Ustilago echinata infection following an open distal tibia fracture, review the current literature of this genus as a cause of invasive fungal infection in humans, and discuss management issues. ...
journal_title:Mycopathologia
pub_type: 杂志文章,评审
doi:10.1007/s11046-015-9967-1
更新日期:2016-04-01 00:00:00
abstract::The mycoflora of nine varieties of grain sorghum was determined by plating serial dilutions of ground samples on rose bengal-streptomycin agar. Seventeen species of fungi representing 10 genera were identified. Curvularia, Penicillium, Mucor, and Aspergillus were dominant genera. Extracts of P. herquei were highly tox...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/BF00439062
更新日期:1981-07-10 00:00:00
abstract::Knowledge about the clinical and laboratory characteristics and prognosis of Talaromyces marneffei infection in children is limited. A retrospective study was conducted on pediatric patients with disseminated T. marneffei infection in a clinical setting. Extracted data included demographic information (age and sex), c...
journal_title:Mycopathologia
pub_type: 杂志文章
doi:10.1007/s11046-019-00373-4
更新日期:2019-12-01 00:00:00