Abstract:
:We previously described an in vitro assay showing that neutrophils (PMNs) from patients with paracoccidioidomycosis (PARA) have a specific digestive deficiency against suspensions of live Paracoccidioides brasiliensis. We now report that this defect is equally detectable against autoclaved, but not Amphotericin B-killed P. brasiliensis. The use of autoclaved suspensions facilitates the use of our in vitro assay. It might allow the development of an in vitro intradermal test for digestion of fungi. Differential digestive ability of phagocytes against live (or autoclaved) and Amphotericin-B killed fungi is of conceptual interest. It may be relevant in understanding therapeutic effect of Amphotericin B.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Goihman-Yahr M,Rothenberg A,Bretaña A,Istúriz G,Rosquete R,Avila-Millán E,Viloria N,Saavedra de Borges N,Carrasquero M,Pérez de Fernández Bdoi
10.1007/BF00436927subject
Has Abstract,Author List Incompletepub_date
1989-04-01 00:00:00pages
53-8issue
1eissn
0301-486Xissn
1573-0832journal_volume
106pub_type
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