Digestion of killed Paracoccidioides brasiliensis by neutrophils.

Abstract:

:We previously described an in vitro assay showing that neutrophils (PMNs) from patients with paracoccidioidomycosis (PARA) have a specific digestive deficiency against suspensions of live Paracoccidioides brasiliensis. We now report that this defect is equally detectable against autoclaved, but not Amphotericin B-killed P. brasiliensis. The use of autoclaved suspensions facilitates the use of our in vitro assay. It might allow the development of an in vitro intradermal test for digestion of fungi. Differential digestive ability of phagocytes against live (or autoclaved) and Amphotericin-B killed fungi is of conceptual interest. It may be relevant in understanding therapeutic effect of Amphotericin B.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Goihman-Yahr M,Rothenberg A,Bretaña A,Istúriz G,Rosquete R,Avila-Millán E,Viloria N,Saavedra de Borges N,Carrasquero M,Pérez de Fernández B

doi

10.1007/BF00436927

subject

Has Abstract,Author List Incomplete

pub_date

1989-04-01 00:00:00

pages

53-8

issue

1

eissn

0301-486X

issn

1573-0832

journal_volume

106

pub_type

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