The effects of the Penicillium mycotoxins citrinin, cyclopiazonic acid, ochratoxin A, patulin, penicillic acid, and roquefortine C on in vitro proliferation of porcine lymphocytes.

Abstract:

:The in vitro effect of each of the Penicillium mycotoxins citrinin (CIT), cyclopiazonic acid (CPA), ochratoxin A (OTA), patulin (PAT), penicillic acid (PIA) and roquefortine C (RQC) on mitogen induced lymphocyte proliferation was determined using purified lymphocytes from 6 piglets. Dose response curves for each mycotoxin were generated and the concentrations producing 50% inhibition of cell proliferation (IC(50)) were estimated. OTA and PAT were the most potent toxins with IC(50) of 1.3 and 1.2 micromol/l, respectively (0.52 and 0.18 mg/l, respectively). Based on molar concentrations, OTA was 15, 30, 40, and 65 times more potent as an inhibitor than PIA, CIT, CPA and RQC, respectively.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Keblys M,Bernhoft A,Höfer CC,Morrison E,Larsen HJ,Flåøyen A

doi

10.1007/s11046-005-5523-8

keywords:

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

317-24

issue

3

eissn

0301-486X

issn

1573-0832

journal_volume

158

pub_type

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