Abstract:
:The in vitro effect of each of the Penicillium mycotoxins citrinin (CIT), cyclopiazonic acid (CPA), ochratoxin A (OTA), patulin (PAT), penicillic acid (PIA) and roquefortine C (RQC) on mitogen induced lymphocyte proliferation was determined using purified lymphocytes from 6 piglets. Dose response curves for each mycotoxin were generated and the concentrations producing 50% inhibition of cell proliferation (IC(50)) were estimated. OTA and PAT were the most potent toxins with IC(50) of 1.3 and 1.2 micromol/l, respectively (0.52 and 0.18 mg/l, respectively). Based on molar concentrations, OTA was 15, 30, 40, and 65 times more potent as an inhibitor than PIA, CIT, CPA and RQC, respectively.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Keblys M,Bernhoft A,Höfer CC,Morrison E,Larsen HJ,Flåøyen Adoi
10.1007/s11046-005-5523-8keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
317-24issue
3eissn
0301-486Xissn
1573-0832journal_volume
158pub_type
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