Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis.

Abstract:

:Talaromyces marneffei, previously known as Penicillium marneffei, is the most important pathogenic thermally dimorphic fungus causing systemic mycosis in Southeast Asia. Traditionally, T. marneffei infection in human was mainly associated with acquired immunodeficiency syndrome caused by HIV infection. In recent years, there has been an increasing number of T. marneffei infections reported in non-HIV-infected patients with other immunocompromised conditions, including autoantibodies against interferon-gamma, systemic lupus erythematosis, solid organ transplantation, Job's syndrome, hematological malignancies, and use of novel targeted therapies. In this article, we describe the first case of fatal T. marneffei infection in a patient with underlying autoimmune hepatitis, presented as fever without localizing features. The diagnosis of talaromycosis was confirmed with the identification of the fungi isolated from the blood culture specimen by conventional methods and using matrix-assisted laser desorption-ionization time-of-flight mass spectrometer. This case shows the importance of a high index of suspicion, particularly for such a highly fatal but potentially treatable fungal infection.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Wong SCY,Sridhar S,Ngan AHY,Chen JHK,Poon RWS,Lau SKP,Woo PCY

doi

10.1007/s11046-017-0239-0

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

615-618

issue

3

eissn

0301-486X

issn

1573-0832

pii

10.1007/s11046-017-0239-0

journal_volume

183

pub_type

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