Abstract:
:Talaromyces marneffei, previously known as Penicillium marneffei, is the most important pathogenic thermally dimorphic fungus causing systemic mycosis in Southeast Asia. Traditionally, T. marneffei infection in human was mainly associated with acquired immunodeficiency syndrome caused by HIV infection. In recent years, there has been an increasing number of T. marneffei infections reported in non-HIV-infected patients with other immunocompromised conditions, including autoantibodies against interferon-gamma, systemic lupus erythematosis, solid organ transplantation, Job's syndrome, hematological malignancies, and use of novel targeted therapies. In this article, we describe the first case of fatal T. marneffei infection in a patient with underlying autoimmune hepatitis, presented as fever without localizing features. The diagnosis of talaromycosis was confirmed with the identification of the fungi isolated from the blood culture specimen by conventional methods and using matrix-assisted laser desorption-ionization time-of-flight mass spectrometer. This case shows the importance of a high index of suspicion, particularly for such a highly fatal but potentially treatable fungal infection.
journal_name
Mycopathologiajournal_title
Mycopathologiaauthors
Wong SCY,Sridhar S,Ngan AHY,Chen JHK,Poon RWS,Lau SKP,Woo PCYdoi
10.1007/s11046-017-0239-0subject
Has Abstractpub_date
2018-06-01 00:00:00pages
615-618issue
3eissn
0301-486Xissn
1573-0832pii
10.1007/s11046-017-0239-0journal_volume
183pub_type
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