Bupropion sustained release for treatment of tobacco dependence.

Abstract:

:Tobacco use is a global pandemic. The most common pharmacological treatments of tobacco use and dependence include nicotine replacement therapy and nonnicotine medications. Bupropion sustained release (SR) is the only first-line nonnicotine medication recommended by the US Public Health Service Clinical Practice Guideline. Randomized controlled clinical trials have shown that bupropion SR doubles abstinence rates compared with placebo. Long-term treatment with bupropion SR may reduce or delay smoking relapse. Bupropion SR has an excellent adverse effect profile, although a risk exists for serious adverse effects such as seizures. The risk of serious adverse effects associated with bupropion SR can be reduced by careful selection of patients. This article reviews the evidence of efficacy and common adverse effects of bupropion SR and delineates the clinical characteristics of patients at higher risk for adverse effects when bupropion SR is prescribed for treatment of tobacco use and dependence.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Hays JT,Ebbert JO

doi

10.4065/78.8.1020

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

1020-4; quiz 1024

issue

8

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)63149-2

journal_volume

78

pub_type

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