The science and ethics of induced pluripotency: what will become of embryonic stem cells?

abstract：OBJECTIVE:To investigate the association between physical activity (PA) and risk of mortality in a large middle-aged cohort stratified by inflammatory status. PATIENTS AND METHODS:A total of 336,560 individuals (mean age, 39.7 years; 58% male) who underwent comprehensive health screenings were enrolled in this prospec...

journal_title：Mayo Clinic proceedings

authors： Lee JY,Ryu S,Cheong E,Sung KC

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To estimate cancer risks for patients with myotonic dystrophy, given that increased risks for neoplasms in association with myotonic dystrophy type 1 and type 2 have been suggested in several studies but the risks of cancers have not been quantified. PATIENTS AND METHODS:A cohort of 307 patients with myotoni...

journal_title：Mayo Clinic proceedings

authors： Win AK,Perattur PG,Pulido JS,Pulido CM,Lindor NM

更新日期：2012-02-01 00:00:00

abstract：UNLABELLED:Cirrhosis and liver cancer, the main causes of liver-related morbidity and mortality, result from defective repair of liver injury. This article summarizes rapidly evolving knowledge about liver myofibroblasts and progenitors, the 2 key cell types that interact to orchestrate effective repair, because deregu...

journal_title：Mayo Clinic proceedings

authors： Machado MV,Diehl AM

更新日期：2014-01-01 00:00:00

abstract：:All women who enter menopause experience amenorrhea unless they receive hormone replacement therapy. In younger women, amenorrhea unrelated to pregnancy and lactation can be a distressing symptom. In addition to its psychologic morbidity, amenorrhea may be the manifesting feature of a wide array of anatomic and endocr...

journal_title：Mayo Clinic proceedings

authors： McIver B,Romanski SA,Nippoldt TB

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:To determine the separate effects of exercise intensity and amount on interindividual cardiorespiratory fitness (CRF) response. PARTICIPANTS AND METHODS:Participants were 121 (75 females, 62%) sedentary, middle-aged (mean [SD] age, 53.2 [7.5] years), abdominally obese adults who completed at least 90% of 5 w...

journal_title：Mayo Clinic proceedings

authors： Ross R,de Lannoy L,Stotz PJ

更新日期：2015-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis is an insidiously developing, adult-onset, progressive anterior horn cell degeneration with associated degeneration of descending motor pathways. It has been recognized as an important clinical syndrome since the middle of the 19th century. Despite increasing clinical and research interes...

journal_title：Mayo Clinic proceedings

authors： Williams DB,Windebank AJ

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To review the association of coronary artery calcification with coronary atherosclerosis and its potential clinical application as detected on electron beam computed tomography (EBCT). DESIGN:A literature review of coronary artery calcification, coronary artery disease, and EBCT is presented, and clinical ap...

journal_title：Mayo Clinic proceedings

authors： Rumberger JA,Sheedy PF 2nd,Breen JF,Fitzpatrick LA,Schwartz RS

更新日期：1996-04-01 00:00:00

abstract：:During the past 20 years, the diagnosis and treatment of ectopic pregnancy have improved considerably. With the current diagnostic modalities, patients at risk for ectopic pregnancy can be followed expectantly, and the diagnosis can be made within a few days of the time of anticipated menses. An enhanced understanding...

journal_title：Mayo Clinic proceedings

authors： Ory SJ

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:To examine the effects of interval walking training (IWT) on the estimated peak aerobic capacity (eV˙O2peak) and lifestyle-related disease (LSD) score while focusing on exercise intensity and volume in middle-aged and older people. PARTICIPANTS AND METHODS:Men and women (N=679; mean age, 65±7 SD years) compl...

journal_title：Mayo Clinic proceedings

authors： Masuki S,Morikawa M,Nose H

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:To determine the clinical characteristics of hospitalized patients who died of pulmonary embolism, confirmed by evaluative autopsy. DESIGN:We retrospectively analyzed a series of autopsy cases of pulmonary embolism at a tertiary-care center for the period Jan. 1, 1985, through Dec. 31, 1989. MATERIAL AND ME...

journal_title：Mayo Clinic proceedings

authors： Morgenthaler TI,Ryu JH

更新日期：1995-05-01 00:00:00

abstract：:A 33-year-old woman with acute idiopathic postganglionic panautonomic neuropathy experienced prompt recovery of all dysautonomic symptoms after receiving high-dose intravenous immunoglobulin therapy. Her recovery was complete within 6 months after onset of disease. This unusually rapid and complete recovery in compari...

journal_title：Mayo Clinic proceedings

authors： Smit AA,Vermeulen M,Koelman JH,Wieling W

更新日期：1997-04-01 00:00:00

abstract：:Dual-chamber pacing improved hemodynamics acutely in a subset of patients with left ventricular (LV) dysfunction but conveyed no long-term symptomatic benefit in most. More recently, LV pacing and biventricular (multisite) pacing have been used to improve systolic contractility by altering the electrical and mechanica...

journal_title：Mayo Clinic proceedings

authors： Gerber TC,Nishimura RA,Holmes DR Jr,Lloyd MA,Zehr KJ,Tajik AJ,Hayes DL

更新日期：2001-08-01 00:00:00

abstract：:Considerable morbidity and mortality are associated with infections of vascular prosthetic grafts. Most vascular surgeons believe that once vascular prosthetic graft infections occur, any form of therapy short of removal of the prosthesis will fail. Although recent reports have noted the successful conservative treatm...

journal_title：Mayo Clinic proceedings

authors： Knight CD Jr,Farnell MB,Hollier LH

更新日期：1983-07-01 00:00:00

abstract：:Abdominal apoplexy is a clinical entity characterized by spontaneous intraperitoneal hemorrhage from rupture of a visceral vessel. We describe a 34-year-old man who presented with abdominal apoplexy due to rupture of an ileocolic aneurysm. Subsequent biochemical and genetic analysis confirmed the diagnosis of Ehlers-D...

journal_title：Mayo Clinic proceedings

authors： Hassan I,Rasmussen TE,Schwarze U,Rose PS,Whiteman DA,Gloviczki P

更新日期：2002-08-01 00:00:00

abstract：:In almost all dialysis patients, bone aluminum content (BAC) is elevated in comparison with levels in normal subjects. Extremely high BAC (200 micrograms or more of aluminum per gram of bone) is significantly associated with classic aluminum-related osteomalacia. We noted three patients with elevated BAC but without h...

journal_title：Mayo Clinic proceedings

authors： McCarthy JT,Kurtz SB,McCall JT

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathwa...

journal_title：Mayo Clinic proceedings

authors： Pastori D,Pignatelli P,Menichelli D,Violi F,Lip GYH

更新日期：2019-07-01 00:00:00

abstract：:The Mayo Three-Community Hypertension Control Program implemented graduated programs for the control of high blood pressure in three rural southeastern Minnesota communities, beginning in 1974. Prevalence of hypertension (when defined as diastolic blood pressure, at initial screening, of 95 mm Hg or more) was similar ...

journal_title：Mayo Clinic proceedings

authors： Labarthe DR,Krishan I,Nobrega FT,Brennan LA Jr,Smoldt RK,Mori HD,Hunt JC

更新日期：1979-05-01 00:00:00

abstract：:We used a laparoscopic technique for the percutaneous placement of the peritoneal end of cerebrospinal fluid shunts in adult patients with obstructive or normal-pressure hydrocephalus. Concurrent with the initial cranial part of the procedure, pneumoperitoneum is established in a routine fashion, and a video-laparosco...

journal_title：Mayo Clinic proceedings

authors： Schievink WI,Wharen RE Jr,Reimer R,Pettit PD,Seiler JC,Shine TS

更新日期：1993-11-01 00:00:00

abstract：:Mechanical and bioprosthetic mitral prostheses may have many potential complications. In patients with isolated mitral stenosis and a small left ventricular cavity, low-profile prostheses are recommended to avoid myocardial impingement that can result from a high-profile valve and lead to possible left ventricular inf...

journal_title：Mayo Clinic proceedings

authors： Currie PJ,Seward JB,Lam JB,Gersh BJ,Pluth JR

更新日期：1985-03-01 00:00:00

abstract：:We reviewed the epidemiologic characteristics, diagnosis, clinical features, and management of cytomegalovirus (CMV) infection after renal transplantation. CMV, the major viral pathogen after renal transplantation, increases patient morbidity and mortality. The spectrum of CMV infection ranges from latent infection to...

journal_title：Mayo Clinic proceedings

authors： Farrugia E,Schwab TR

更新日期：1992-09-01 00:00:00

abstract：:Transesophageal echocardiography (TEE) is used frequently in patients with cerebrovascular ischemia. On TEE, a typical appearance of a cardiac fibroelastoma is that of a pedunculated, mobile mass attached to a leaflet of a valve. Surgical excision of the lesion may lead to resolution of the symptoms and prevent furthe...

journal_title：Mayo Clinic proceedings

authors： Brown RD Jr,Khandheria BK,Edwards WD

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:To determine the incidence and temporal trends of food allergies. PATIENTS AND METHODS:We performed a historical cohort study to describe the epidemiology of food allergies among residents of all ages in Olmsted County, Minnesota, during a 10-year period from January 2, 2002, through December 31, 2011, using...

journal_title：Mayo Clinic proceedings

authors： Willits EK,Park MA,Hartz MF,Schleck CD,Weaver AL,Joshi AY

更新日期：2018-10-01 00:00:00

abstract：:Pulmonary hypertension (PH) in patients with interstitial lung diseases (ILDs) is not well recognized and can occur in the absence of advanced pulmonary dysfunction or hypoxemia. To address this topic, we identified relevant studies in the English language by searching the MEDLINE database (1966 to November 2006) and ...

journal_title：Mayo Clinic proceedings

authors： Ryu JH,Krowka MJ,Pellikka PA,Swanson KL,McGoon MD

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To Investigate the frequency of valvular heart disease in patients taking pergolide. PATIENTS AND METHODS:The medical records of patients seen at the Mayo Clinic in Jacksonville, Fla, between 1998 and 2003 were searched electronically for the word pergolide and the presence of a 2-dimensional echocardiogram....

journal_title：Mayo Clinic proceedings

authors： Waller EA,Kaplan J,Heckman MG

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of laparoscopy in the diagnosis of intra-abdominal lymphoma. PATIENTS AND METHODS:The medical records of patients with suspected primary or recurrent lymphoma who underwent laparoscopy between March 1991 and March 2003 were reviewed. Demographic, clinical, operative, and pathologic dat...

journal_title：Mayo Clinic proceedings

authors： Asoglu O,Porter L,Donohue JH,Cha SS

更新日期：2005-05-01 00:00:00

abstract：:Constrictive pericarditis frequently poses a diagnostic challenge because of its varied manifestations. Accurate diagnosis is essential, however, because surgical decortication may yield excellent clinical results. Although new diagnostic procedures have helped the clinician to diagnose constrictive pericarditis, the ...

journal_title：Mayo Clinic proceedings

authors： Nishimura RA,Connolly DC,Parkin TW,Stanson AW

更新日期：1985-06-01 00:00:00

abstract：:Primary care physicians are more likely to see patients with depression than with any other disorder except hypertension, and its management poses a challenge to busy primary care practices. The Patient Health Questionnaire-9, a simple self-administered tool of proven validity and reliability, is a commonly used scree...

journal_title：Mayo Clinic proceedings

authors： Dejesus RS,Vickers KS,Melin GJ,Williams MD

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To study the impact of parental leave on extending residency training and the timing of entrance into the specialty board certification examination system. METHODS:From June 3, 2005, through December 28, 2005, primary specialty board policies regarding parental leave, absence from training, and the timing of...

journal_title：Mayo Clinic proceedings

authors： Rose SH,Burkle CM,Elliott BA,Koenig LF

更新日期：2006-11-01 00:00:00

abstract：:Dyspnea is a common symptom that is difficult to define and can result from a wide variety of causes. This complex sensation that arises from multiple stimuli involves both subjective perceptions and objective reactions. In the assessment of patients with dyspnea, use of a systematic approach to determine the precipit...

journal_title：Mayo Clinic proceedings

authors： Gillespie DJ,Staats BA

更新日期：1994-07-01 00:00:00

abstract：:Thromboembolic complications continue to be potential hazards in patients with prosthetic heart valves, and cerebral infarct and transient neurologic deficits as a result of embolism are the most common manifestations. Actual thrombotic obstruction of the valve occurs less frequently but is often fatal unless it is re...

journal_title：Mayo Clinic proceedings

authors： Kontos GJ Jr,Schaff HV

更新日期：1985-02-01 00:00:00