Fulminant hepatitis: Mayo Clinic experience with 34 cases.

Abstract:

:From 1974 through 1982, fulminant hepatitis was diagnosed in 34 patients at our institution. Of these patients, only two survived (survival rate, 6%). This syndrome was caused by viruses (B and non-B hepatitis and herpes simplex) in 23 patients, hepatotoxic drug in 6, Wilson's disease (hepatolenticular degeneration) in 3, and industrial poisons in 2. Most of the patients died within 10 days after the onset of encephalopathy. The poor prognosis in our group of patients was probably related to the preponderance of older patients and cases caused by non-B hepatitis virus. In our patients, the clinical course was complicated by renal failure, ascites, bleeding, sepsis, pancreatitis, and seizures. The major cause of death was hepatic failure.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Rakela J,Lange SM,Ludwig J,Baldus WP

doi

10.1016/s0025-6196(12)60534-5

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

289-92

issue

5

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(12)60534-5

journal_volume

60

pub_type

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