A seven-year follow-up of men following a benign prostate biopsy.

Abstract:

OBJECTIVES:To determine the incidence and clinical relevance of newly diagnosed cases of prostate cancer in a group of men who had an elevated PSA and benign prostate biopsy 7 years previously. PATIENTS AND METHOD:Patients under the age of 80 years with an elevated PSA who had had a benign prostate biopsy in the 12 months between March 1, 1994 and February 28, 1995 were studied. One hundred and sixty four patients with a mean age of 66.8 years (range 47-79 years) were identified. The mean PSA for this group was 10.3ng/ml (range 4.1-81ng/ml). One hundred and fifty nine of the 164 (97%) hospital records were available for review and all but 21 (12.8%) of the General Practitioners were contacted. RESULTS:Eighteen (11%) of the original 164 patients were subsequently diagnosed with prostate cancer, 2 died from their disease. CONCLUSIONS:In a population where the follow-up of patients with a benign biopsy was arranged on clinical grounds alone, 11% of the study group were diagnosed with prostate cancer during a seven-year follow-up. Although some of these cancers appear to be slow growing, most of those diagnosed in the initial follow-up period were deemed to be clinically significant and a small proportion progressed rapidly to metastases. All patients who have an elevated PSA, but benign biopsy, should undergo a period of PSA monitoring until it is clear that their PSA is not rising. We propose an initial intensive monitoring period to avoid missing those with clinically aggressive disease.

journal_name

Eur Urol

journal_title

European urology

authors

Boddy JL,Pike DJ,Malone PR

doi

10.1016/s0302-2838(03)00205-7

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

17-20

issue

1

eissn

0302-2838

issn

1873-7560

pii

S0302283803002057

journal_volume

44

pub_type

杂志文章
  • The Mainz pouch (mixed augmentation ileum 'n zecum) for bladder augmentation and continent urinary diversion.

    abstract::A new technique for fashioning an ileocecal pouch, applicable for both bladder augmentation and continent urinary diversion, is described. A low pressure reservoir is achieved by antimesenteric longitudinal transsection of ileum and cecum and formation of a pouch from the cecum and two ileal loops. The antireflux proc...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472481

    authors: Thüroff JW,Alken P,Engelmann U,Riedmiller H,Jacobi GH,Hohenfellner R

    更新日期:1985-01-01 00:00:00

  • Intermittent complete androgen blockade in PSA relapse after radical prostatectomy and incidental prostate cancer.

    abstract:OBJECTIVES:To determine the efficacy, safety and feasibility of intermittent androgen deprivation (IAD) in patients with prostate-specific antigen (PSA) relapse after radical prostatectomy or with an incidental prostate cancer (pT1B) after transurethral resection of the prostate (TURP). METHODS:Open, nonrandomized, pr...

    journal_title:European urology

    pub_type: 杂志文章

    doi:

    authors: Kurek R,Renneberg H,Lübben G,Kienle E,Tunn UW

    更新日期:1999-01-01 00:00:00

  • Treatment of invasive grade 3 transitional cell bladder cancer. A retrospective study of 10 years' experience with external irradiation, and preoperative irradiation and cystectomy.

    abstract::Three hundred and seventy-four patients with invasive grade 3 bladder cancer treated with either external irradiation or preoperative irradiation and cystectomy were re-evaluated. Cancer-free survival was markedly better for patients who underwent preoperative irradiation and operation than irradiation only, even if a...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472805

    authors: Wijkström H,Edsmyr F,Nilsson B

    更新日期:1987-01-01 00:00:00

  • Prostate-specific antigen velocity for early detection of prostate cancer: result from a large, representative, population-based cohort.

    abstract:BACKGROUND:It has been suggested that changes in prostate-specific antigen (PSA) over time (ie, PSA velocity [PSAV]) aid prostate cancer detection. Some guidelines do incorporate PSAV cut points as an indication for biopsy. OBJECTIVE:To evaluate whether PSAV enhances prediction of biopsy outcome in a large, representa...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2009.07.047

    authors: Vickers AJ,Wolters T,Savage CJ,Cronin AM,O'Brien MF,Pettersson K,Roobol MJ,Aus G,Scardino PT,Hugosson J,Schröder FH,Lilja H

    更新日期:2009-11-01 00:00:00

  • Improving the Specificity of Screening for Lethal Prostate Cancer Using Prostate-specific Antigen and a Panel of Kallikrein Markers: A Nested Case-Control Study.

    abstract:BACKGROUND:A disadvantage of prostate-specific antigen (PSA) for the early detection of prostate cancer (PCa) is that many men must be screened, biopsied, and diagnosed to prevent one death. OBJECTIVE:To increase the specificity of screening for lethal PCa at an early stage. DESIGN, SETTING, AND PARTICIPANTS:We condu...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2015.01.009

    authors: Stattin P,Vickers AJ,Sjoberg DD,Johansson R,Granfors T,Johansson M,Pettersson K,Scardino PT,Hallmans G,Lilja H

    更新日期:2015-08-01 00:00:00

  • EAU guidelines on iatrogenic trauma.

    abstract:CONTEXT:The European Association of Urology (EAU) Trauma Guidelines Panel presents an updated iatrogenic trauma section of their guidelines. Iatrogenic injuries are known complications of surgery to the urinary tract. Timely and adequate intervention is key to their management. OBJECTIVE:To assess the optimal evaluati...

    journal_title:European urology

    pub_type: 杂志文章,实务指引

    doi:10.1016/j.eururo.2012.05.058

    authors: Summerton DJ,Kitrey ND,Lumen N,Serafetinidis E,Djakovic N,European Association of Urology.

    更新日期:2012-10-01 00:00:00

  • A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells.

    abstract:BACKGROUND:Primary culture and animal and cell-line models of prostate and bladder development have limitations in describing human biology, and novel strategies that describe the full spectrum of differentiation from foetal through to ageing tissue are required. Recent advances in biology demonstrate that direct repro...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2013.03.054

    authors: Moad M,Pal D,Hepburn AC,Williamson SC,Wilson L,Lako M,Armstrong L,Hayward SW,Franco OE,Cates JM,Fordham SE,Przyborski S,Carr-Wilkinson J,Robson CN,Heer R

    更新日期:2013-11-01 00:00:00

  • Computerised assessment of maximum urinary flow: an efficient, consistent and valid approach.

    abstract:OBJECTIVES:To evaluate the relative accuracy of a computerised method to quantitatively assess maximum urinary flow. METHODS:A total of 1147 uroflows were evaluated by the computerised method and by three experts from different European countries. The sample consisted of uroflows from the respective visits by a 20% sa...

    journal_title:European urology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0302-2838(01)00037-9

    authors: Witjes WP,de la Rosette JJ,van den Berg-Segers A,Colongo D,Koch G,Zlotta AR,Colau A,de Wildt MJ,Wijkstra H

    更新日期:2002-02-01 00:00:00

  • Gonadal hormones in long-term survivors 10 years after treatment for unilateral testicular cancer.

    abstract:OBJECTIVE:To investigate whether unilaterally orchiectomised testicular cancer survivors (TCSs) are more likely to display reduced Leydig cell function than healthy males. METHODS:A national multi-centre survey of 1235 TCSs was performed in 1998-2000 (mean age: 44 years) treated between 1980 and 1994 (mean follow-up: ...

    journal_title:European urology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0302-2838(03)00263-x

    authors: Nord C,Bjøro T,Ellingsen D,Mykletun A,Dahl O,Klepp O,Bremnes RM,Wist E,Fosså SD

    更新日期:2003-09-01 00:00:00

  • Anticholinergic Burden in the Elderly Population: An Emerging Concern.

    abstract::Antimuscarinics are commonly used to treat overactive bladder, but increase anticholinergic burden, which has been associated with multiple adverse outcomes in older patients. We advocate for standardization of anticholinergic risk assessment and reevaluation of anticholinergic prescribing practices for the elderly. ...

    journal_title:European urology

    pub_type: 社论

    doi:10.1016/j.eururo.2019.03.021

    authors: Pierce H,Thomas D,Asfaw T,Chughtai B

    更新日期:2019-07-01 00:00:00

  • Lymphoedema in urological cancer.

    abstract:OBJECTIVES:To review the evidence underlying the diagnosis, pathology and treatment of lymphoedema of the lower extremities and genitalia from or following the treatment for urological cancer, and to suggest possible underlying pathophysiological mechanisms that may explain its development. METHODS:Reviews of the epid...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2003.08.010

    authors: Okeke AA,Bates DO,Gillatt DA

    更新日期:2004-01-01 00:00:00

  • Value of ultrasound-guided systematic sextant biopsies in prostate tumor mapping.

    abstract:OBJECTIVE:To determine the value of positive sextant biopsies in assessing the location of prostate tumors within radical prostatectomy specimens and to determine if prostate weight influences the results. METHODS:From 1988 to 1996, 166 radical prostatectomies were performed for localized prostate cancer diagnosed by ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000019863

    authors: Salomon L,Colombel M,Patard JJ,Lefrère-Belda MA,Bellot J,Chopin D,Abbou CC

    更新日期:1999-04-01 00:00:00

  • The Incremental Role of Magnetic Resonance Imaging for Prostate Cancer Staging before Radical Prostatectomy.

    abstract::In the present report we aimed to analyze the incremental value of preoperative magnetic resonance imaging (MRI), in addition to clinical variables and clinically-derived nomograms, in predicting outcomes radical prostatectomy (RP). All Mayo Clinic RP patients who underwent preoperative 1.5-Tesla MRI with endo-rectal ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2016.08.015

    authors: Morlacco A,Sharma V,Viers BR,Rangel LJ,Carlson RE,Froemming AT,Karnes RJ

    更新日期:2017-05-01 00:00:00

  • Familial and hereditary prostate cancer by definition in an italian surgical series: clinical features and outcome.

    abstract:OBJECTIVE:To evaluate the clinical impact of different definitions of hereditary prostate cancer (PCa), the relative risk (RR) of relatives of PCa cases and differences in clinical-pathological features and outcome as function of a family history in a surgical series exposed to Mediterranean diet. METHODS:We classifie...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2005.01.016

    authors: Sacco E,Prayer-Galetti T,Pinto F,Ciaccia M,Fracalanza S,Betto G,Pagano F

    更新日期:2005-06-01 00:00:00

  • Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair.

    abstract:CONTEXT:Varicocele is a common condition, found in many men who present for infertility evaluation. OBJECTIVE:To assess the effect of varicocelectomy on male infertility. EVIDENCE ACQUISITION:A literature search was performed using Embase and Medline. Literature reviewed included meta-analyses and randomized and nonr...

    journal_title:European urology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.eururo.2011.06.018

    authors: Baazeem A,Belzile E,Ciampi A,Dohle G,Jarvi K,Salonia A,Weidner W,Zini A

    更新日期:2011-10-01 00:00:00

  • Perioperative morbidity of the extended radical perineal prostatectomy.

    abstract:PURPOSE:Perioperative morbidity is an essential indicator for the quality of an operative technique. This fact is especially important in radical prostatectomy since different treatment modalities may provide similar outcome in terms of local tumor control. MATERIALS AND METHODS:The conventional type of radical perine...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000049764

    authors: Brehmer B,Borchers H,Kirschner-Hermanns R,Biesterfeld S,Jakse G

    更新日期:2001-08-01 00:00:00

  • Postchemotherapy retroperitoneal lymph node dissection in advanced germ cell tumours of the testis.

    abstract:OBJECTIVES:To review the role of postchemotherapy retroperitoneal lymph node dissection (PC-RPLND) in patients with advanced testicular germ cell tumours (TGCT) with special attention towards the indication, surgical technique, and oncological outcome. METHODS:A structured review of the literature until May 2007 using...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1016/j.eururo.2007.10.033

    authors: Heidenreich A,Thüer D,Polyakov S

    更新日期:2008-02-01 00:00:00

  • Robotic partial nephrectomy versus laparoscopic cryoablation for the small renal mass.

    abstract:BACKGROUND:Open partial nephrectomy (OPN) remains the gold standard for treatment of small renal masses (SRMs). Laparoscopic cryoablation (LCA) has provided encouraging outcomes. Robotic partial nephrectomy (RPN) represents a new promising option but is still under evaluation. OBJECTIVE:Compare the outcomes of RPN and...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2012.01.007

    authors: Guillotreau J,Haber GP,Autorino R,Miocinovic R,Hillyer S,Hernandez A,Laydner H,Yakoubi R,Isac W,Long JA,Stein RJ,Kaouk JH

    更新日期:2012-05-01 00:00:00

  • Microvascular changes in the early stage of reflux pyelonephritis. An experimental study in the pig kidney.

    abstract::Renal microvascular changes were studied in the pig kidney during the initial stage of reflux pyelonephritis. In 10 piglets vesicoureteric reflux was surgically induced. The animals were then infected with a strain of Escherichia coli and sacrificed 2 weeks following the initiation of infection. Following injection of...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000472782

    authors: Androulakakis PA,Ransley PG,Risdon RA,Sorger K,Hohenfellner R

    更新日期:1987-01-01 00:00:00

  • Pharmacological management of incontinence.

    abstract::Many patients with incontinence do not need surgery - for these patients symptoms can often be considerably improved by conservative measures, including drugs. Several different pharmacological actions are potentially useful depending on the underlying cause of the incontinence: a) Detrusor instability (DI) responds t...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000052327

    authors: Sullivan J,Abrams P

    更新日期:1999-01-01 00:00:00

  • Neutron therapy of bladder carcinoma: can a high rate of severe complications be avoided in neutron therapy?

    abstract::We reviewed retrospectively a series of 58 patients with deeply invasive bladder cancer treated with fast neutron therapy (p(65) + Be) in order to evaluate its tolerance and side effects. Patients were divided into three groups according to treatment technique. Patients of group A received whole pelvis irradiation up ...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000474262

    authors: Kirkove C,Richard F,Van Cangh PJ,Ledent G,Octave-Prignot M,Wambersie A

    更新日期:1993-01-01 00:00:00

  • Use of immunohistochemically demonstrated c-erb B-2 oncoprotein expression as a prognostic factor in transitional cell carcinoma of the urinary bladder.

    abstract::Formalin-fixed, paraffin-embedded specimens from 91 primary transitional cell cancers (TCC) of the urinary bladder were stained with a monoclonal antibody to c-erb B-2 oncoprotein. Twelve percent (11/91) of the TCC stained for c-erb b-2 oncoprotein, and in 4% (4/91) of cases, the expression was graded as moderate or h...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000471706

    authors: Lipponen P,Eskelinen M,Syrjänen S,Tervahauta A,Syrjänen K

    更新日期:1991-01-01 00:00:00

  • Benign prostatic hyperplasia: symptoms and objective interpretation.

    abstract::Considerable new knowledge about benign prostatic hyperplasia has been gained over the past two decades, particularly with regard to its natural history, hydrodynamic changes in the lower urinary tract, and the symptomatic and urodynamic results of treatment. A survey of the literature has been undertaken with special...

    journal_title:European urology

    pub_type: 杂志文章,评审

    doi:10.1159/000471744

    authors: Andersen JT

    更新日期:1991-01-01 00:00:00

  • Higher Risk of Fragility Fractures in Prostate Cancer Patients Treated with Combined Radium-223 and Abiraterone: Prednisone May Be the Culprit.

    abstract::Results from the ERA 223 trial of abiraterone combined with radium-223 among men with chemotherapy-naïve castration-resistant prostate cancer and bone metastases show no improvement in survival free from symptomatic skeletal events. We hypothesize that this finding might be attributable to bone loss induced by the con...

    journal_title:European urology

    pub_type: 评论,社论

    doi:10.1016/j.eururo.2019.01.026

    authors: Dalla Volta A,Formenti AM,Berruti A

    更新日期:2019-06-01 00:00:00

  • Late coronary stent thrombosis complicating urologic surgery.

    abstract::The current practice of withdrawing antiplatelet therapy before major surgery has been challenged by the introduction of coronary drug-eluting stents (DESs) since evidence is accumulating that a DES requires dual antiplatelet therapy for at least a year. The authors present a case demonstrating difficulty in decision-...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2007.10.005

    authors: de Korte FI,van Werkum JW,Vijverberg PL,Ten Berg JM

    更新日期:2008-07-01 00:00:00

  • Robotic Partial Nephrectomy: The Will Rogers Surgical Effect.

    abstract::Comparison of surgical techniques must be critically and objectively evaluated, ideally in the context of prospective trials. Comprehensive surgical training ensures that patients are offered the most appropriate treatment and highest clinical care. ...

    journal_title:European urology

    pub_type: 评论,社论

    doi:10.1016/j.eururo.2015.07.033

    authors: George AK,Hartman C,Kavoussi LR

    更新日期:2016-01-01 00:00:00

  • Reliability of clinical assessment of fluid absorption in transurethral prostatic resection.

    abstract::We evaluated 5 frequently used clinical methods of assessing absorption of irrigation fluid during 118 transurethral prostatic resections. The use of an irrigating solution containing glycine 1.5% and ethanol 1% and subsequent analysis of the alcohol concentration in the exhaled breath (ethanol monitoring) served as c...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000474306

    authors: Olsson J,Rentzhog L,Hjertberg H,Hahn RG

    更新日期:1993-01-01 00:00:00

  • Surgical treatment of 31 complex traumatic posterior urethral strictures associated with urethrorectal fistulas.

    abstract:BACKGROUND:Urethrorectal fistulas (URF) in patients with complex posterior urethral strictures are rare and difficult to repair surgically. There is no widely accepted standard approach described in the published literature. OBJECTIVE:The aim of this study was to describe the outcomes of various operative approaches f...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2009.02.035

    authors: Xu YM,Sa YL,Fu Q,Zhang J,Jin SB

    更新日期:2010-03-01 00:00:00

  • The prevalence of clinically meaningful overactive bladder: bother and quality of life results from the population-based FINNO study.

    abstract:BACKGROUND:Wide variation exists in prevalence estimates of overactive bladder (OAB) syndrome. OBJECTIVE:To determine how the frequency of urinary urgency or urgency urinary incontinence (UUI)--the cornerstone symptoms of OAB--affects symptom-related bother, health-related quality of life (HRQL), and ultimately clinic...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1016/j.eururo.2011.01.031

    authors: Vaughan CP,Johnson TM 2nd,Ala-Lipasti MA,Cartwright R,Tammela TL,Taari K,Auvinen A,Tikkinen KA

    更新日期:2011-04-01 00:00:00

  • Prevention of vasospasms during extensive renal surgery. An experimental study in rats.

    abstract::Six methods for prevention of renal arterial vasospasms, due to extensive surgical trauma are compared in an experimental study in rats. The 'proximal transit time' was chosen as a measure for renal arterial flow 1, 5, 10 and 15 min after a standard surgical trauma. Xylocaine infiltration around the renal pedicle was ...

    journal_title:European urology

    pub_type: 杂志文章

    doi:10.1159/000473224

    authors: De Maeyer P,Oosterlinck W,De Sy W

    更新日期:1981-01-01 00:00:00