Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.

abstract：:F1-ATPase, the catalytic domain of ATP synthase, synthesizes most of the ATP in living organisms. Running in reverse powered by ATP hydrolysis, this hexameric ring-shaped molecular motor formed by three αβ-dimers creates torque on its central γ-subunit. This reverse operation enables detailed explorations of the mecha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okazaki K,Hummer G

更新日期：2013-10-08 00:00:00

abstract：:Ascorbic acid, at nontoxic concentrations, causes a substantial reduction in the ability of avian tumor viruses to replicate in both primary avian tendon cells and chicken embryo fibroblasts. The virus-infected cultures appear to be less transformed in the presence of ascorbic acid by the criteria of morphology, reduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bissell MJ,Hatie C,Farson DA,Schwarz RI,Soo WJ

更新日期：1980-05-01 00:00:00

abstract：:Aluminum (Al) is the most abundant metal in the Earth's crust, but its trivalent ionic form is highly toxic to all organisms at low concentrations. How Al enters cells has not been elucidated in any organisms. Herein, we report a transporter, Nrat1 (Nramp aluminum transporter 1), specific for trivalent Al ion in rice....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia J,Yamaji N,Kasai T,Ma JF

更新日期：2010-10-26 00:00:00

abstract：:The polyamines, putrescine, spermidine, and spermine, are essential polycations, intimately involved in the regulation of cellular proliferation. Although polyamines exert dynamic effects on the conformation of nucleic acids and macromolecular synthesis in vitro, their specific functions in vivo are poorly understood....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mandal S,Mandal A,Johansson HE,Orjalo AV,Park MH

更新日期：2013-02-05 00:00:00

abstract：:Cullin-Ring E3 ubiquitin ligases target substrates for ubiquitin-dependent, proteasome-mediated degradation and regulate critical cellular processes. These cullins assemble with cellular substrate receptor proteins through specific adaptor molecules. F-box- and BC-box-containing receptors use Skp1, ElonginB, and Elong...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo K,Xiao Z,Ehrlich E,Yu Y,Liu B,Zheng S,Yu XF

更新日期：2005-08-09 00:00:00

abstract：:A randomized double-blind controlled trial was conducted to determine the efficacy of passive immunotherapy in the treatment of symptomatic human immunodeficiency virus (HIV) infection. This trial included 86 symptomatic patients randomized to receive plasma rich in anti-HIV-1 antibody or standard seronegative plasma....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vittecoq D,Chevret S,Morand-Joubert L,Heshmati F,Audat F,Bary M,Dusautoir T,Bismuth A,Viard JP,Barré-Sinoussi F

更新日期：1995-02-14 00:00:00

abstract：:One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with relatively larger lesions generally did not display a CR. To investiga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Welters MJ,Kenter GG,de Vos van Steenwijk PJ,Löwik MJ,Berends-van der Meer DM,Essahsah F,Stynenbosch LF,Vloon AP,Ramwadhdoebe TH,Piersma SJ,van der Hulst JM,Valentijn AR,Fathers LM,Drijfhout JW,Franken KL,Oostendorp J,Fle

更新日期：2010-06-29 00:00:00

abstract：:Topographic sensory maps are a prominent feature of the adult primate brain. Here, we asked whether topographic representations of the body are present at birth. Using functional MRI (fMRI), we find that the newborn somatomotor system, spanning frontoparietal cortex and subcortex, comprises multiple topographic repres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arcaro MJ,Schade PF,Livingstone MS

更新日期：2019-12-03 00:00:00

abstract：:Several significant steps have been completed toward a general method for the site-specific incorporation of unnatural amino acids into proteins in vivo. An "orthogonal" suppressor tRNA was derived from Saccharomyces cerevisiae tRNA2Gln. This yeast orthogonal tRNA is not a substrate in vitro or in vivo for any Escheri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu DR,Schultz PG

更新日期：1999-04-27 00:00:00

abstract：:Skin wound infections are a significant health problem, and antibiotic resistance is on the rise. Mast cells (MCs) have been shown to contribute to host-defense responses in certain bacterial infections, but their role in skin wound superinfection is unknown. We subjected 2 MC-deficient mouse strains to Pseudomonas ae...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zimmermann C,Troeltzsch D,Giménez-Rivera VA,Galli SJ,Metz M,Maurer M,Siebenhaar F

更新日期：2019-10-08 00:00:00

abstract：:Colonization of land by plants was a major transition on Earth, but the developmental and genetic innovations required for this transition remain unknown. Physiological studies and the fossil record strongly suggest that the ability of the first land plants to form symbiotic associations with beneficial fungi was one ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delaux PM,Radhakrishnan GV,Jayaraman D,Cheema J,Malbreil M,Volkening JD,Sekimoto H,Nishiyama T,Melkonian M,Pokorny L,Rothfels CJ,Sederoff HW,Stevenson DW,Surek B,Zhang Y,Sussman MR,Dunand C,Morris RJ,Roux C,Wong GK

更新日期：2015-10-27 00:00:00

abstract：:The cytochrome P-450 superfamily of enzymes catalyzes the oxidative metabolism of innumerable lipophilic compounds (e.g., drugs, carcinogens, steroids). Although the three-dimensional structure of a soluble bacterial P-450 (P-450cam) has been solved, little is known about the structures of the membrane-bound mammalian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronbach T,Larabee TM,Johnson EF

更新日期：1989-11-01 00:00:00

abstract：:Fms-like tyrosine kinase 1 (Flt1)/vascular endothelial growth factor (VEGF) receptor 1, a receptor for VEGF-A and placental growth factor, is expressed in the spongiotrophoblast layer that segregates the maternal and fetal vasculature in the mouse placenta. A soluble form of Flt1 (sFlt1) produced in the mouse and huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirashima M,Lu Y,Byers L,Rossant J

更新日期：2003-12-23 00:00:00

abstract：:In the last 60,000 y humans have expanded across the globe and now occupy a wider range than any other terrestrial species. Our ability to successfully adapt to such a diverse range of habitats is often explained in terms of our cognitive ability. Humans have relatively bigger brains and more computing power than othe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd R,Richerson PJ,Henrich J

更新日期：2011-06-28 00:00:00

abstract：:The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubule-destabilizing agents. Here, we determined the high-resolution crystal structure of the complex between tubulin and maytansine, which is part of an ADC that is approved by the US Food and Drug A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prota AE,Bargsten K,Diaz JF,Marsh M,Cuevas C,Liniger M,Neuhaus C,Andreu JM,Altmann KH,Steinmetz MO

更新日期：2014-09-23 00:00:00

abstract：:The ability to regulate gene expression through transcription initiation underlies the adaptability and survival of all bacteria. Recent work has revealed that the transcription machinery in many bacteria diverges from the paradigm that has been established in Escherichia coliMycobacterium tuberculosis (Mtb) encodes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu DX,Garner AL,Galburt EA,Stallings CL

更新日期：2019-07-02 00:00:00

abstract：:Acute and chronic injuries to the heart result in perturbation of intracellular calcium signaling, which leads to pathological cardiac hypertrophy and remodeling. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the transduction of calcium signals in the heart, but the specific isoforms o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backs J,Backs T,Neef S,Kreusser MM,Lehmann LH,Patrick DM,Grueter CE,Qi X,Richardson JA,Hill JA,Katus HA,Bassel-Duby R,Maier LS,Olson EN

更新日期：2009-02-17 00:00:00

abstract：:RNA viruses are notorious for their genetic plasticity and propensity to exploit new host-range opportunities, which can lead to the emergence of human disease epidemics such as severe acute respiratory syndrome, AIDS, dengue, and influenza. However, the mechanisms of host-range change involved in most of these viral ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anishchenko M,Bowen RA,Paessler S,Austgen L,Greene IP,Weaver SC

更新日期：2006-03-28 00:00:00

abstract：:After primary infection, human cytomegalovirus (HCMV) persists as a life-long latent infection, with host immunosuppression often resulting in clinical reactivation. During lytic infection, major changes in the expression of secreted cellular proteins (the secretome) occur that have profound effects on host-cell inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason GM,Poole E,Sissons JG,Wills MR,Sinclair JH

更新日期：2012-09-04 00:00:00

abstract：:A defined, minimal medium for the cellular slime mold Dictyostelium discoideum is reported. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franke J,Kessin R

更新日期：1977-05-01 00:00:00

abstract：:The intestinal mucosa exists in dynamic balance with trillions of luminal microbes. Disruption of the intestinal epithelial barrier, commonly observed in mucosal inflammation and diseases such as inflammatory bowel diseases (IBDs), is often associated with dysbiosis, particularly decreases in species producing short-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang RX,Lee JS,Campbell EL,Colgan SP

更新日期：2020-05-26 00:00:00

abstract：:The transcription factor interferon regulatory factor 5 (IRF5) is essential for the induction of inflammatory cytokines, but the mechanism by which IRF5 is activated is not well understood. Here we present evidence that the kinase IKKβ phosphorylates and activates IRF5 in response to stimulation in several inflammator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ren J,Chen X,Chen ZJ

更新日期：2014-12-09 00:00:00

abstract：:We describe here the 1.7-A resolution structure of a single-chain antibody variable domain (scFv) molecule, based on the carbohydrate-binding antibody Se155-4, complexed with the trisaccharide ligand alpha-D-Gal(1-->2)[alpha-D-Abe(1-->3)]alpha-D-Manp1-->OMe, where Abe is abequose. The scFv expressed in Escherichia col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zdanov A,Li Y,Bundle DR,Deng SJ,MacKenzie CR,Narang SA,Young NM,Cygler M

更新日期：1994-07-05 00:00:00

abstract：:The plant viruses alfalfa mosaic virus (AMV) and brome mosaic virus (BMV) each divide their genetic information among three RNAs while tobacco mosaic virus (TMV) contains a single genomic RNA. Amino acid sequence comparisons suggest that the single proteins encoded by AMV RNA 1 and BMV RNA 1 and by AMV RNA 2 and BMV R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haseloff J,Goelet P,Zimmern D,Ahlquist P,Dasgupta R,Kaesberg P

更新日期：1984-07-01 00:00:00

abstract：:The intracellular pathogen Salmonella enterica serovar Typhimurium requires the mgtC gene to cause disease. The mgtC transcript includes a long leader region that harbors a short proline codon-rich ORF--termed mgtP--the translation of which is predicted to favor formation of one of two alternative stem-loop structures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee EJ,Choi J,Groisman EA

更新日期：2014-02-25 00:00:00

abstract：:PKC eta is expressed predominantly in the epithelial tissues; however, its role in the regulation of epithelial tight junctions (TJs) is unknown. We present evidence that PKC eta phosphorylates occludin on threonine residues (T403 and T404) and plays a crucial role in the assembly and/or maintenance of TJs in Caco-2 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki T,Elias BC,Seth A,Shen L,Turner JR,Giorgianni F,Desiderio D,Guntaka R,Rao R

更新日期：2009-01-06 00:00:00

abstract：:Almost all theoretical and experimental studies of the mechanisms underlying learning and memory focus on synaptic efficacy and make the implicit assumption that changes in synaptic efficacy are both necessary and sufficient to account for learning and memory. However, network dynamics depends on the complex interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marder E,Abbott LF,Turrigiano GG,Liu Z,Golowasch J

更新日期：1996-11-26 00:00:00

abstract：:In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closely integrated and we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maughan SC,Pasternak M,Cairns N,Kiddle G,Brach T,Jarvis R,Haas F,Nieuwland J,Lim B,Müller C,Salcedo-Sora E,Kruse C,Orsel M,Hell R,Miller AJ,Bray P,Foyer CH,Murray JA,Meyer AJ,Cobbett CS

更新日期：2010-02-02 00:00:00

abstract：:Experiments reported here show that some UV-irradiated wild-type T7 phage markers can be rescued efficiently by coinfection with T7 amber mutant phage in a permissive host. Other results show that the segments of a UV-irradiated genome that replicate efficiently are those that also are rescued efficiently during a mar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burck KB,Miller RC Jr

更新日期：1978-12-01 00:00:00

abstract：:Assembly of nitrogenase FeMoco is one of the key processes in bioinorganic chemistry. NifB and NifEN are two essential elements immediately adjacent to each other along the biosynthetic pathway of FeMoco. Previously, an 8Fe-precursor of FeMoco was identified on NifEN; however, the identity of the biosynthetic intermed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wiig JA,Hu Y,Ribbe MW

更新日期：2011-05-24 00:00:00