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Specific interactions of distamycin with G-quadruplex DNA.

Abstract：

:Distamycin binds the minor groove of duplex DNA at AT-rich regions and has been a valuable probe of protein interactions with double-stranded DNA. We find that distamycin can also inhibit protein interactions with G-quadruplex (G4) DNA, a stable four-stranded structure in which the repeating unit is a G-quartet. Using NMR, we show that distamycin binds specifically to G4 DNA, stacking on the terminal G-quartets and contacting the flanking bases. These results demonstrate the utility of distamycin as a probe of G4 DNA-protein interactions and show that there are (at least) two distinct modes of protein-G4 DNA recognition which can be distinguished by sensitivity to distamycin.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Cocco MJ,Hanakahi LA,Huber MD,Maizels N

doi

10.1093/nar/gkg392

keywords:

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

2944-51

issue

11

eissn

0305-1048

issn

1362-4962

journal_volume

31

pub_type

杂志文章

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