Abstract：
:alpha3beta1-integrin is abundantly expressed in the epidermis, and in mice, ablation of the alpha3 gene results in embryonic defects and perinatal lethality. To determine the role of alpha3-integrin in adult skin development, we grafted skin from newborn alpha3-integrin-deficient mice on to ICRF nu/nu recipients. We report that adult alpha3-integrin-deficient skin has severe abnormalities restricted to hair follicle morphology, which include stunted hair follicle growth, increased hair follicle fragility, aberrant pigment accumulation and formation of hair follicle clusters. These abnormalities are caused by a combination of defects in: (1) keratinocyte cytoskeletal organisation, (2) outer root sheath architecture and (3) integrity of the lamina densa. Our results indicate that alpha3beta1 is not essential for adult interfollicular epidermal differentiation, but it is required to direct several processes important in hair follicle maintenance and morphogenesis.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Conti FJ,Rudling RJ,Robson A,Hodivala-Dilke KMdoi
10.1242/jcs.00475keywords:
subject
Has Abstractpub_date
2003-07-01 00:00:00pages
2737-47issue
Pt 13eissn
0021-9533issn
1477-9137pii
jcs.00475journal_volume
116pub_type
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