Fibroblastic foci in usual interstitial pneumonia: idiopathic versus collagen vascular disease.

abstract：:We investigated the source of intravascular fat in systemic organs (brain, heart, and kidney) after massive pulmonary fat embolism during cemented arthroplasty. We used a bilateral cemented arthroplasty (BCA) in anesthetized mongrel dogs that simulates a cemented total-hip replacement procedure. We hypothesized that d...

journal_title：American journal of respiratory and critical care medicine

authors： Byrick RJ,Mullen JB,Mazer CD,Guest CB

更新日期：1994-11-01 00:00:00

abstract：:Induced sputum using hypertonic saline (HS) is a useful research tool to study airway inflammation (AI). HS provocation testing can also be used to measure airway hyperresponsiveness (AHR). A combined HS challenge and sputum induction procedure has been developed to permit assessment of AI and AHR in a single test. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Jones PD,Hankin R,Simpson J,Gibson PG,Henry RL

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:Exhaled nitric oxide (NO) is a well-known marker of established airway inflammation in asthma. Its role in the disease process before the onset of respiratory symptoms remains unclear. OBJECTIVES:To examine whether elevated NO in newborns with clinically naive airways is associated with subsequent respirator...

journal_title：American journal of respiratory and critical care medicine

authors： Latzin P,Kuehni CE,Baldwin DN,Roiha HL,Casaulta C,Frey U

更新日期：2006-12-15 00:00:00

abstract：:Diabetes mellitus has been inconsistently associated with a reduced level of pulmonary function. To elucidate this association further, we analyzed the relationship of diabetes and of fasting blood glucose to the level of pulmonary function assessed by spirometry in the 3,254 members of the Framingham Offspring Cohort...

journal_title：American journal of respiratory and critical care medicine

authors： Walter RE,Beiser A,Givelber RJ,O'Connor GT,Gottlieb DJ

更新日期：2003-03-15 00:00:00

abstract：:We hypothesized that variation in extubating brain injured patients would affect the incidence of nosocomial pneumonia, length of stay, and hospital charges. In a prospective cohort of consecutive, intubated brain-injured patients, we evaluated daily: intubation status, spontaneous ventilatory parameters, gas exchange...

journal_title：American journal of respiratory and critical care medicine

authors： Coplin WM,Pierson DJ,Cooley KD,Newell DW,Rubenfeld GD

更新日期：2000-05-01 00:00:00

abstract：:Genetic factors may contribute to the variability of exhaled nitric oxide in healthy individuals. We studied exhaled nitric oxide and genetic variants in both neuronal and endothelial nitric oxide synthases in 105 healthy nonsmoking and smoking subjects. Genomic DNA was screened for a repeat polymorphism in intron 20 ...

journal_title：American journal of respiratory and critical care medicine

authors： Grasemann H,Storm van's Gravesande K,Buscher R,Drazen JM,Ratjen F

更新日期：2003-04-15 00:00:00

abstract：:Tracheal gas insufflation (TGI) has been recommended as an adjunct to mechanical ventilation in the presence of elevated Pa CO2. Based on our initial clinical experience with continuous flow TGI and pressure control ventilation (PCV), we were concerned about elevation in peak airway pressure as TGI was applied. In a l...

journal_title：American journal of respiratory and critical care medicine

authors： Imanaka H,Kacmarek RM,Ritz R,Hess D

更新日期：1996-03-01 00:00:00

abstract：:Alveolar epithelial type II cells (AET2) respond with exocytosis of surfactant containing lamellar bodies to stimulation with mechanical stretch and secretagogues, a process that is fundamental for maintaining alveolar stability and lung gas exchange. In the present study in cultured rat AET2, we employed botulinum C2...

journal_title：American journal of respiratory and critical care medicine

authors： Rose F,Kürth-Landwehr C,Sibelius U,Reuner KH,Aktories K,Seeger W,Grimminger F

更新日期：1999-01-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic disorder underlain by aberrant wound healing of repeated lung injury. Environmental triggers and genetic background are likely to act as modifiers of the fibrotic response. Erythrocyte complement receptor 1 is a membrane protein mediating the transport of immu...

journal_title：American journal of respiratory and critical care medicine

authors： Zorzetto M,Ferrarotti I,Trisolini R,Lazzari Agli L,Scabini R,Novo M,De Silvestri A,Patelli M,Martinetti M,Cuccia M,Poletti V,Pozzi E,Luisetti M

更新日期：2003-08-01 00:00:00

abstract：:Decision analysis was used to compare three alternative strategies for a 6-mo course of treatment for tuberculosis: directly observed drug therapy (DOT), self-administered fixed-dose combination drug therapy, and self-administered conventional individual drug therapy. Estimates of effectiveness were obtained from the ...

journal_title：American journal of respiratory and critical care medicine

authors： Moore RD,Chaulk CP,Griffiths R,Cavalcante S,Chaisson RE

更新日期：1996-10-01 00:00:00

abstract：RATIONALE:Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. OBJECTIVE...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson WH,Coakley RD,Button B,Henderson AG,Zeman KL,Alexis NE,Peden DB,Lazarowski ER,Davis CW,Bailey S,Fuller F,Almond M,Qaqish B,Bordonali E,Rubinstein M,Bennett WD,Kesimer M,Boucher RC

更新日期：2015-07-15 00:00:00

abstract：:Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocyte...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan BP,Michelson AD

更新日期：2006-03-01 00:00:00

abstract：:We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CL...

journal_title：American journal of respiratory and critical care medicine

authors： Davidson D,Drafta D,Wilkens BA

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with several pathophysiological deficits found in diabetic retinopathy (DR). Hence, it's plausible that OSA could play a role in the pathogenesis of sight-threatening DR (STDR). OBJECTIVES:To assess the relationship between OSA and DR in patients with type 2 diabet...

journal_title：American journal of respiratory and critical care medicine

authors： Altaf QA,Dodson P,Ali A,Raymond NT,Wharton H,Fellows H,Hampshire-Bancroft R,Shah M,Shepherd E,Miah J,Barnett AH,Tahrani AA

更新日期：2017-10-01 00:00:00

abstract：RATIONALE:The relationship between clinical phenotype of childhood primary ciliary dyskinesia (PCD) and ultrastructural defects and genotype is poorly defined. OBJECTIVES:To delineate clinical features of childhood PCD and their associations with ultrastructural defects and genotype. METHODS:A total of 118 participan...

journal_title：American journal of respiratory and critical care medicine

authors： Davis SD,Ferkol TW,Rosenfeld M,Lee HS,Dell SD,Sagel SD,Milla C,Zariwala MA,Pittman JE,Shapiro AJ,Carson JL,Krischer JP,Hazucha MJ,Cooper ML,Knowles MR,Leigh MW

更新日期：2015-02-01 00:00:00

abstract：:The purpose of this study was to evaluate the physiologic responses to endurance training in patients with moderate to severe airflow obstruction by specifically looking at changes in skeletal muscle enzymatic activities. Eleven patients (age = 65 +/- 7 yr, mean +/- SD, FEV1 = 36 +/- 11% of predicted value, range = 24...

journal_title：American journal of respiratory and critical care medicine

authors： Maltais F,LeBlanc P,Simard C,Jobin J,Bérubé C,Bruneau J,Carrier L,Belleau R

更新日期：1996-08-01 00:00:00

abstract：:Effective treatment of tuberculosis requires adherence to a minimum of 6 months treatment with multiple drugs. To improve adherence and cure rates, directly observed therapy is recommended for the treatment of pulmonary tuberculosis. We compared treatment outcomes among all culture-positive patients treated for active...

journal_title：American journal of respiratory and critical care medicine

authors： Jasmer RM,Seaman CB,Gonzalez LC,Kawamura LM,Osmond DH,Daley CL

更新日期：2004-09-01 00:00:00

abstract：:The Pulmonary Complications of HIV Infection Study is a prospective, multicenter, observational study evaluating pulmonary disease among HIV-infected persons. For approximately 52 mo, 1,182 HIV-infected subjects were followed. All participants were evaluated for pulmonary disease on a predetermined schedule. There wer...

journal_title：American journal of respiratory and critical care medicine

authors： Stansell JD,Osmond DH,Charlebois E,LaVange L,Wallace JM,Alexander BV,Glassroth J,Kvale PA,Rosen MJ,Reichman LB,Turner JR,Hopewell PC

更新日期：1997-01-01 00:00:00

abstract：:Sarcoidosis is a systemic disorder of unknown origin, primarily affecting the lungs. The granulomatous inflammation is driven by the interplay between various molecules and cells, including T cells. Previously, our group reported a close correlation between lung-restricted T-cell receptor (TCR) AV2S3 CD4-positive T-ce...

journal_title：American journal of respiratory and critical care medicine

authors： Katchar K,Wahlström J,Eklund A,Grunewald J

更新日期：2001-06-01 00:00:00

abstract：:Impaired lung epithelial Na(+) channel (ENaC) activity at the time of birth results in respiratory distress. To investigate potential mechanisms, the ontogeny and cellular distribution of the alphaENaC subunit mRNA expression was studied in normal, immature, and abnormal (hypoplastic) human fetal lungs using nonradioi...

journal_title：American journal of respiratory and critical care medicine

authors： Smith DE,Otulakowski G,Yeger H,Post M,Cutz E,O'Brodovich HM

更新日期：2000-04-01 00:00:00

abstract：:Rationale: Sleep-disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker of which is increased platelet activation.Objectives: This study compared whole-blood impedance platelet aggregation ...

journal_title：American journal of respiratory and critical care medicine

authors： Kontos A,Willoughby S,Lushington K,Martin J,Wabnitz D,Dorrian J,Kennedy D

更新日期：2020-12-01 00:00:00

abstract：:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mT...

journal_title：American journal of respiratory and critical care medicine

authors： Morrison D,Rahman I,Lannan S,MacNee W

更新日期：1999-02-01 00:00:00

abstract：:Airway hyperresponsiveness in asthma has been attributed to impaired ability of deep inspiration (DI) to stretch airway smooth muscle. We have retested this hypothesis by comparing the responses to methacholine of 10 asthmatic and 10 control subjects. After each dose subjects breathed tidally without deep inspiration ...

journal_title：American journal of respiratory and critical care medicine

authors： Burns GP,Gibson GJ

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:Conversion from a negative to positive QuantiFERON-TB test is indicative of Mycobacterium tuberculosis (Mtb) infection, which predisposes individuals to tuberculosis disease. Interpretation of serial tests is confounded by immunological and technical variability. OBJECTIVES:To improve the consistency of seri...

journal_title：American journal of respiratory and critical care medicine

authors： Nemes E,Rozot V,Geldenhuys H,Bilek N,Mabwe S,Abrahams D,Makhethe L,Erasmus M,Keyser A,Toefy A,Cloete Y,Ratangee F,Blauenfeldt T,Ruhwald M,Walzl G,Smith B,Loxton AG,Hanekom WA,Andrews JR,Lempicki MD,Ellis R,Ginsb

更新日期：2017-09-01 00:00:00

abstract：:Patients with pulmonary Mycobacterium avium complex (MAC) infection occasionally have neither past histories of pulmonary diseases nor underlying immunodeficiency conditions. Therefore, we hypothesized that MAC may be linked with a disease-susceptibility gene and determined human leukocyte-associated antigens (HLA) in...

journal_title：American journal of respiratory and critical care medicine

authors： Takahashi M,Ishizaka A,Nakamura H,Kobayashi K,Nakamura M,Namiki M,Sekita T,Okajima S

更新日期：2000-07-01 00:00:00

abstract：:The effects of glutathione-S-transferase (GST) M1, GSTT1, and GSTP1 genotypes on lung function growth were investigated in 1,940 children enrolled in the Children's Health Study as fourth graders (aged 8-11 years) in two cohorts during 1993 and 1996 and were followed annually over a 4-year period. Genotypes for GSTM1 ...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Gauderman WJ,Vora H,Rappaport E,Dubeau L

更新日期：2002-09-01 00:00:00

abstract：:Asthma in children and young adults is strongly associated with immediate hypersensitivity to indoor allergens, notably those derived from the house dust mite. In addition, outdoor air pollution is considered to aggravate existing asthma. We investigated the prevalence of asthma and the pattern of allergen sensitizati...

journal_title：American journal of respiratory and critical care medicine

authors： Sporik R,Ingram JM,Price W,Sussman JH,Honsinger RW,Platts-Mills TA

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:Sarcoidosis is known as a disease with high heterogeneity in clinical severity and inflammatory activity. On the basis of radiologic criteria, John Guyette Scadding developed a classification system, which is widely used, but is insufficient for clinical decision making. Therefore, biomarkers and genetic mark...

journal_title：American journal of respiratory and critical care medicine

authors： Prasse A,Katic C,Germann M,Buchwald A,Zissel G,Müller-Quernheim J

更新日期：2008-02-01 00:00:00

abstract：:This study aimed to estimate exposure-response relationships for mesothelioma and environmental exposure to crocidolite. All 4,659 former residents of Wittenoom, Western Australia (WA) who lived there between 1943 and 1993 for at least 1 mo and were not directly employed in the crocidolite industry, were followed-up t...

journal_title：American journal of respiratory and critical care medicine

authors： Hansen J,de Klerk NH,Musk AW,Hobbs MS

更新日期：1998-01-01 00:00:00

abstract：RATIONALE:The relation between birth weight and respiratory symptoms and asthma in children remains unclear. Previous studies focused on a relation at separate ages. A longitudinal analysis may lead to a better understanding. OBJECTIVES:To estimate the effect of birth weight on the development and course of respirator...

journal_title：American journal of respiratory and critical care medicine

authors： Caudri D,Wijga A,Gehring U,Smit HA,Brunekreef B,Kerkhof M,Hoekstra M,Gerritsen J,de Jongste JC

更新日期：2007-05-15 00:00:00