Abstract:
:Acute demyelinating optic neuritis associated with multiple sclerosis (MS) is the most common cause of inflammation of the optic nerve. The Optic Neuritis Treatment Trial (ONTT) has provided important clinical data on the use of corticosteroids, and demonstrated that patients with characteristic inflammatory lesions within the brain on magnetic resonance imaging had a greater chance of developing clinically definite MS (CDMS). The current approach to patients with optic neuritis has been modified by the results of the Controlled High-Risk Subjects Avonex Multiple Sclerosis Prevention Study (CHAMPS). Patients with an initial clinical episode of demyelination (optic neuritis, incomplete transverse myelitis, or brain-stem/cerebellar syndrome) and at least two characteristic demyelinating lesions within the brain were randomized to receive interferon beta-1a or placebo after initial treatment with intravenous corticosteroids. At the 3-year point patients treated with interferon beta-1a showed a 50% less risk of CDMS. The results of this study have set the standard for patients with a first bout of demyelinating optic neuritis.
journal_name
Curr Opin Ophthalmoljournal_title
Current opinion in ophthalmologyauthors
Foroozan R,Buono LM,Savino PJ,Sergott RCdoi
10.1097/00055735-200212000-00006keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
375-80issue
6eissn
1040-8738issn
1531-7021journal_volume
13pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Corneal transplantation is the most commonly performed solid organ transplantation in the world. Despite a glorious history of more than a 100 years, the success of conventional corneal transplantation surgery is marred by problems like graft rejection,graft infection and associated glaucoma due to lo...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:2010-07-01 00:00:00
abstract::Several different laser types are available on the market for the practitioner to use in refractive surgery. Each laser type has certain parameters that the surgeon must understand to obtain the best refractive outcomes. Studies published in peer-reviewed literature between February 2002 and March 2003 show that refra...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200308000-00008
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abstract::A seven-stage approach to the management of the paretic eyelid complex has been described. These stages include supportive care, planning and execution of general facial reanimation, lower eyelid and canthal resuspension or support, passive upper eyelid animation, dynamic lid animation, and soft tissue repositioning. ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199908000-00004
更新日期:1999-08-01 00:00:00
abstract:PURPOSE OF REVIEW:The introduction of hydrogel socket and orbital expanders has modified the approach towards the rehabilitation of congenital anophthalmia. This study highlights the most recent advances for the treatment of congenital anophthalmia based on personal experience and the review of recent literature. RECE...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328349948a
更新日期:2011-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The history, pharmacology, indications, complications, and success rates of botulinum administration are discussed in this review as they relate to strabismus and associated conditions. RECENT FINDINGS:Botulinum has been used to treat strabismus and a variety of other ocular conditions for over three...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000243018.97627.4c
更新日期:2006-10-01 00:00:00
abstract::There have been many recent advances in the diagnosis and management of children with retinoblastoma. Regarding diagnosis, the judicial use of ancillary studies, particularly B-scan ultrasonography, has been instrumental in supplementing the diagnosis when opaque media preclude a clear view of the underlying neoplasm...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199406000-00014
更新日期:1994-06-01 00:00:00
abstract::The possibility for visual improvement after the treatment of subfoveal choroidal neovascular membranes with laser photocoagulation is poor. The surgical excision of these membranes in age-related macular degeneration, the presumed ocular histoplasmosis syndrome, idiopathic neovascularization, and myopia is the focus ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199306000-00004
更新日期:1993-06-01 00:00:00
abstract::As the number and types of keratorefractive procedures increase and as the baby boomer population moves into the "cataractous decades," the number of patients requiring cataract surgery following refractive surgery grows larger each year. While technological advances in surgical instrumentation and intraocular lens (I...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-200302000-00008
更新日期:2003-02-01 00:00:00
abstract::Cataract surgery continues to evolve as modifications in techniques are introduced. Extracapsular surgery, whether by phacoemulsification or planned extracapsular cataract extraction, is a very safe and effective technique. Maintaining versatility in operative techniques, depending on the clinical situation, is a di...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199302000-00008
更新日期:1993-02-01 00:00:00
abstract:PURPOSE OF REVIEW:An update on recent work is provided that has broadened our understanding of the evaluation of visual function and structure, and their use in evaluating glaucoma progression. RECENT FINDINGS:The challenge of determining visual-field progression and the implications of long-term fluctuation are revie...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/01.icu.0000193089.52561.ac
更新日期:2006-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma. RECENT FINDINGS:Several intraocu...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000550
更新日期:2019-03-01 00:00:00
abstract::Ocular manifestations of systemic malignancy are important for both the ophthalmologist and the internist to recognize because they may precede the diagnosis of cancer. This review of the current literature discusses the clinical manifestations, etiology, and potential therapeutic interventions for a group of visual p...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199912000-00013
更新日期:1999-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Microbial keratitis is one of the leading causes of ocular morbidity. The standard treatment consists of antibiotics, which is intensive and is fraught with risks of antibiotic resistance. Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of micro...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000271
更新日期:2016-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Topography-guided laser refractive surgery regularizes the front corneal surface irregularities to achieve the desired refractive outcome. This is particularly applicable in highly aberrated corneas, where wavefront aberrometry is often not possible. This article aims to review the recently published ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283622a59
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:We assess the studies on vector systems for delivery of transgenes to the cornea that have been published over the last year and summarize new work on the identification of specific transgenes for corneal diseases. RECENT FINDINGS:Adeno-associated viral vectors are increasingly being successfully app...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283541eb6
更新日期:2012-07-01 00:00:00
abstract::Three problems exist when assessing the effectiveness of treatment for normal-tension glaucoma. Firstly, it is a common type of primary open-angle glaucoma. Secondly, the extent to which it is a pressure-sensitive disease remains to be seen. Thirdly, it is possible that normal-tension glaucoma is a collection of diffe...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199504000-00011
更新日期:1995-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Diabetic retinopathy and diabetic macular edema (DME) are common eye diseases leading to vision loss. The Diabetic Retinopathy Clinical Research Network (DRCRnet), a collaboration of private and academic practices supported by the National Eye Institute and the National Institute of Diabetes, Digestiv...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000262
更新日期:2016-05-01 00:00:00
abstract::A wealth of antiallergic drugs is available for ocular allergy, and many new drugs will soon be approved. Pharmaceutical companies frequently seek approval of anti-inflammatory drugs for allergic indications, because it is relatively easy to perform clinical trials for ocular allergy. Extremely safe drugs for mild to ...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199808000-00010
更新日期:1998-08-01 00:00:00
abstract:PURPOSE OF REVIEW:To review new developments in the medical and surgical treatment options for benign essential blepharospasm (BEB). RECENT FINDINGS:Botulinum toxin injections remain the mainstay treatment for BEB with several formulations currently commercially available. Reports in the medical literature support pho...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e3283313d1d
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abstract:PURPOSE OF REVIEW:Neonatal corneal opacification (NCO) describes the loss of corneal transparency at or soon after (<4 weeks) birth. Historically, the literature is strewn with terminology that has been at best misleading and at worst, a hindrance to selecting the appropriate treatment plan for, accurate genotype-pheno...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e328356893d
更新日期:2012-09-01 00:00:00
abstract::A review of the ocular manifestations of pediatric disease is in some ways a review of pediatrics itself. A paper this size cannot hope to be comprehensive in scope or encyclopedic in detail. Instead, we have chosen to touch on recent developments in pediatrics that we feel may be of particular interest to the ophthal...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199812000-00020
更新日期:1998-12-01 00:00:00
abstract::Retinopathy of prematurity is a disease that manifests soon after birth in the premature infant and may lead to a lifelong disability. More infants at risk for developing the retinopathy are surviving, and the ophthalmologist must be aware of possible vision abnormalities, such as decreased acuity, strabismus, nystagm...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199606000-00009
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journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
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更新日期:2015-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to describe the current clinical landscape of potential future therapies for both nonexudative (dry) and exudative (wet) age-related macular degeneration (AMD). We highlight some of the more promising treatments that are furthest along in development. RECENT FINDINGS:Pat...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000657
更新日期:2020-05-01 00:00:00
abstract::Several laser technologies including 1053-nm picosecond, excimer, erbium:yttrium-aluminum-garnet, and neodymium:yttrium-aluminum-garnet (Nd:YAG) have been studied for use in the removal of cataractous lens tissue. Nd:YAG laser phacolysis involves laser pulses striking a titanium target that are incorporated into an i...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/00055735-199302000-00017
更新日期:1993-02-01 00:00:00
abstract:PURPOSE OF REVIEW:A process is ongoing to produce a definition of glaucomatous optic neuropathy (GON) using quantitative, objective data from structural and functional tests. At present, a common practice is to define GON by subjective features said to be 'characteristic' as judged by those experienced in glaucoma care...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Cataracts are a significant cause of blindness and visual impairment worldwide. The present article reviews the literature and describes the current extent of cataracts globally, barriers to treatment, and recommendations for improving the treatment of cataracts. RECENT FINDINGS:Prevalence and absolu...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0000000000000340
更新日期:2017-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The concept of neuroprotective therapy for glaucoma is that damage to retinal ganglion cells (RGCs) may be prevented by intervening in neuronal death pathways. This review focuses on strategies for neuroprotection and summarizes preclinical studies that have investigated potential agents over the last...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:10.1097/ICU.0b013e32834372ec
更新日期:2011-03-01 00:00:00
abstract::Primary open-angle glaucoma is not yet fully understood in terms of its pathophysiologic mechanisms. However, they are being addressed more completely in the recent literature. To the list of known risk factors associated with this disease, systemic influences are now being added. Primary open-angle glaucoma is beco...
journal_title:Current opinion in ophthalmology
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00