Neuroprotection in glaucoma: recent and future directions.

Abstract:

PURPOSE OF REVIEW:The concept of neuroprotective therapy for glaucoma is that damage to retinal ganglion cells (RGCs) may be prevented by intervening in neuronal death pathways. This review focuses on strategies for neuroprotection and summarizes preclinical studies that have investigated potential agents over the last 2 years. RECENT FINDINGS:Part of the challenge of studies in neuroprotection has been the utilization of an animal model that resembles human glaucoma. Several models have been utilized including acute and chronic intraocular pressure elevation, the DBA/2J mouse, optic nerve axotomy and crush. NMDA inhibitors continued to be explored however with limited success in human trials. Memantine failed to demonstrate neuroprotection in phase III clinical trials. Although its mechanism of neuroprotection has not been fully elaborated, topical brimonidine has shown some neuroprotective benefits. Exogeneous neurotrophins delay, but do not prevent, RGC death. Bioenergetic neuroprotection that is enhancing the energy supply to RGC has been explored with benefits in animal models. Other strategies include TNF-α, modulation of the immune system and inflammation, and blocking apoptotic signals and stem cells. SUMMARY:Animal models of glaucoma and neuroprotective strategies continue to be refined. Establishing consensus guidelines for the execution and design of translational research in neuroprotection may optimize the facilitation of neuroprotection research.

journal_name

Curr Opin Ophthalmol

authors

Danesh-Meyer HV

doi

10.1097/ICU.0b013e32834372ec

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

78-86

issue

2

eissn

1040-8738

issn

1531-7021

journal_volume

22

pub_type

杂志文章,评审
  • Tubulointerstitial nephritis and uveitis syndrome.

    abstract:PURPOSE OF REVIEW:Tubulointerstitial nephritis and uveitis syndrome (TINU) is a specific form of intraocular inflammation (uveitis) combined with kidney disease that was first described in two patients by Dobrin et al. in 1975. Since then, approximately 200 more cases have been published. The cause of the disease is st...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3283318f9a

    authors: Mackensen F,Billing H

    更新日期:2009-11-01 00:00:00

  • Pars plana vitrectomy and sutured posterior chamber lens implantation.

    abstract::Transcleral suturing of posterior chamber intraocular lenses (IOLs) was developed to extend the benefits of IOL visual rehabilitation to eyes lacking capsular support and to avoid the complications of closed loop interior chamber IOLs. Although most frequently implanted after complicated cataract surgery or penetratin...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200106000-00013

    authors: Johnston RL,Charteris DG

    更新日期:2001-06-01 00:00:00

  • The Implantable Miniature Telescope for macular degeneration.

    abstract:PURPOSE OF REVIEW:The function is described of the Implantable Miniature Telescope, which is completing clinical development for bilateral end-stage macular degeneration, and 6-month results of the Phase II/III IMT002 prospective, multicenter study are presented. Multispecialty patient management and implications of th...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/01.icu.0000193067.86627.a1

    authors: Lane SS,Kuppermann BD

    更新日期:2006-02-01 00:00:00

  • Review of optical coherence tomography for intraocular tumors.

    abstract:PURPOSE OF REVIEW:Optical coherence tomography has assumed an important role in the management of numerous ocular conditions. With regard to ocular oncology, optical coherence tomography can illustrate retinal changes overlying choroidal tumors. Some of these features include photoreceptor loss, intraretinal edema, and...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/01.icu.0000158258.01681.40

    authors: Shields CL,Materin MA,Shields JA

    更新日期:2005-06-01 00:00:00

  • Cross-linking for microbial keratitis.

    abstract:PURPOSE OF REVIEW:Microbial keratitis is one of the leading causes of ocular morbidity. The standard treatment consists of antibiotics, which is intensive and is fraught with risks of antibiotic resistance. Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of micro...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000271

    authors: Chan TC,Agarwal T,Vajpayee RB,Jhanji V

    更新日期:2016-07-01 00:00:00

  • Amblyopia.

    abstract::New knowledge of the pathophysiology of amblyopia has evolved through animal research over the past 30 years. We now know that development and treatment of amblyopia have a critical and sensitive period. After more than a millennium, patching of the dominant eye remains the cornerstone of amblyopia treatment, and comp...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199610000-00003

    authors: de Faber JT,Kingma-Wilschut C

    更新日期:1996-10-01 00:00:00

  • Ocular toxicology.

    abstract::This review of recent articles on ocular toxicology concentrates on undesirable effects on the eye induced by systemically used xenobiotics. These include color vision deficiencies or visual field deterioration related to antiepileptic drugs, elevated intraocular pressure associated with inhaled corticosteroids, retin...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199712000-00016

    authors: Novack GD

    更新日期:1997-12-01 00:00:00

  • Idiopathic orbital inflammation: a new dimension with the discovery of immunoglobulin G4-related disease.

    abstract:PURPOSE OF REVIEW:To review idiopathic orbital inflammation, with particular reference to the evolving entity of ocular adnexal immunoglobulin G4 (IgG4) disease. RECENT FINDINGS:Emerging evidence suggests that sclerosing idiopathic orbital inflammation can be an IgG4-related disease and discovery of this link has furt...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32835563ec

    authors: Berry-Brincat A,Rose GE

    更新日期:2012-09-01 00:00:00

  • Astigmatism and LASIK.

    abstract::Although laser in situ keratomileusis (LASIK) enjoys a high success rate, postoperative residual or induced astigmatism may limit uncorrected visual acuity and cause starbursts and glare at night. Irregular astigmatism can also cause loss of best-corrected visual acuity, monocular diplopia, and ghosting of images. Ast...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200208000-00012

    authors: Wu HK

    更新日期:2002-08-01 00:00:00

  • Therapeutic rationale for normal-tension glaucoma.

    abstract::Three problems exist when assessing the effectiveness of treatment for normal-tension glaucoma. Firstly, it is a common type of primary open-angle glaucoma. Secondly, the extent to which it is a pressure-sensitive disease remains to be seen. Thirdly, it is possible that normal-tension glaucoma is a collection of diffe...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199504000-00011

    authors: Hitchings RA

    更新日期:1995-04-01 00:00:00

  • Update on scleral lenses.

    abstract:PURPOSE OF REVIEW:Scleral rigid gas-permeable lenses play an important and underappreciated role in the treatment of corneal disease. This review provides an update on scleral rigid gas-permeable lenses for the visual rehabilitation of ectasia and irregular astigmatism, and an update on scleral rigid gas-permeable lens...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e328302cc4f

    authors: Jacobs DS

    更新日期:2008-07-01 00:00:00

  • Glaucoma secondary to intraocular tumors: mechanisms and management.

    abstract:PURPOSE OF REVIEW:Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma. RECENT FINDINGS:Several intraocu...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000550

    authors: Camp DA,Yadav P,Dalvin LA,Shields CL

    更新日期:2019-03-01 00:00:00

  • Clinical features of small choroidal melanoma.

    abstract::The detection and treatment of choroidal melanoma early in its natural course is critical to providing the patient with the best prognosis. Patients with small choroidal melanoma (< 4 mm thickness) develop metastasis in 16% of cases at 5 years follow up, whereas those with medium choroidal melanoma (4-8 mm thickness) ...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200206000-00001

    authors: Shields CL,Shields JA

    更新日期:2002-06-01 00:00:00

  • Amniotic membrane surgery.

    abstract::Human amniotic membrane (AM) is composed of three layers: a single epithelial layer, a thick basement membrane, and an avascular stroma. Amniotic membrane has anti-adhesive properties and is felt to promote epithelialization and decrease inflammation, neovascularization, and fibrosis. Amniotic membrane transplantation...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200108000-00006

    authors: Sippel KC,Ma JJ,Foster CS

    更新日期:2001-08-01 00:00:00

  • Glaucoma therapy and ocular surface disease: current literature and recommendations.

    abstract:PURPOSE OF REVIEW:To provide an update on clinical and experimental literature for ocular surface effects of glaucoma therapy and to provide practical guidelines for ophthalmologists treating glaucoma patients with ocular surface disease (OSD). RECENT FINDINGS:Preservatives, notably benzalkonium chloride (BAK), contin...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32835c8aba

    authors: Anwar Z,Wellik SR,Galor A

    更新日期:2013-03-01 00:00:00

  • Oculoplastic and orbital applications of porous high-density polyethylene implants.

    abstract::Porous high-density polyethylene implants have become well accepted for the repair of orbital wall fractures, delayed orbital reconstruction, orbital rim and malar bony onlay augmentation, and volume replacement as orbital spherical implants for the treatment of anophthalmos. Medpor (Porex Surgical, Inc. College Park,...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199710000-00012

    authors: Purdy EP

    更新日期:1997-10-01 00:00:00

  • Update on retinal detachment surgery.

    abstract:PURPOSE OF REVIEW:Update on controversies in the surgical management of rhegmatogenous retinal detachment. RECENT FINDINGS:There are multiple new reports regarding the development and management of retinal detachment. Current use of oral fluoroquinolones may be associated with onset of retinal detachment, although the...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32835f8e6b

    authors: Schwartz SG,Flynn HW Jr,Mieler WF

    更新日期:2013-05-01 00:00:00

  • Diagnosing glaucoma progression: current practice and promising technologies.

    abstract:PURPOSE OF REVIEW:An update on recent work is provided that has broadened our understanding of the evaluation of visual function and structure, and their use in evaluating glaucoma progression. RECENT FINDINGS:The challenge of determining visual-field progression and the implications of long-term fluctuation are revie...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/01.icu.0000193089.52561.ac

    authors: Giangiacomo A,Garway-Heath D,Caprioli J

    更新日期:2006-04-01 00:00:00

  • Ocular manifestations of giant cell arteritis.

    abstract::Giant cell arteritis is a systemic disease that can have devastating ophthalmic consequences. New insights into the epidemiology and pathophysiology of the disease may improve early diagnosis and treatment. ...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199812000-00013

    authors: Tovilla-Canales JL

    更新日期:1998-12-01 00:00:00

  • Impact of intravitreal pharmacotherapies including antivascular endothelial growth factor and corticosteroid agents on diabetic retinopathy.

    abstract:PURPOSE OF REVIEW:Diabetic retinopathy is common and increasing in prevalence. Pharmacologic management of diabetic macular edema (DME) has improved tremendously over the last decade with the use of two families of intravitreally administered medications: antivascular endothelial growth factor-specific agents and corti...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000364

    authors: Wykoff CC

    更新日期:2017-05-01 00:00:00

  • Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration.

    abstract:PURPOSE OF REVIEW:The most important recent advance in the treatment of neovascular age-related macular degeneration (AMD) is the development of antivascular endothelial growth factor (anti-VEGF) therapeutic agents that preserve and improve visual acuity by arresting choroidal neovascular growth and reducing vascular p...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32832d25b3

    authors: Ciulla TA,Rosenfeld PJ

    更新日期:2009-05-01 00:00:00

  • Lasers in cataract surgery.

    abstract::Several laser technologies including 1053-nm picosecond, excimer, erbium:yttrium-aluminum-garnet, and neodymium:yttrium-aluminum-garnet (Nd:YAG) have been studied for use in the removal of cataractous lens tissue. Nd:YAG laser phacolysis involves laser pulses striking a titanium target that are incorporated into an i...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199302000-00017

    authors: Dodick JM,Lally JM,Sperber LT

    更新日期:1993-02-01 00:00:00

  • Pediatric nasolacrimal duct obstruction.

    abstract:PURPOSE OF REVIEW:Review the current management for pediatric nasolacrimal duct obstruction and congenital dacryocele. RECENT FINDINGS:Early probing in the office, and probing beyond 1 year of age in a facility with general anesthesia are equally effective. Congenital nasolacrimal duct obstruction is associated with a...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3283642e94

    authors: Schnall BM

    更新日期:2013-09-01 00:00:00

  • The impact of cataract surgery on quality of life.

    abstract:PURPOSE OF REVIEW:This review summarizes the recent literature of the impact of cataract surgery from the patient's perspective, with a focus on second-generation patient reported outcome (PRO) measures that used Rasch analysis to explore their data. RECENT FINDINGS:Irrespective of the instrument utilized, the overrid...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3283414284

    authors: Lamoureux EL,Fenwick E,Pesudovs K,Tan D

    更新日期:2011-01-01 00:00:00

  • Intraocular lens calculations in patients with keratoectatic disorders.

    abstract:PURPOSE OF REVIEW:Intraocular lens (IOL) calculations in patients with keratoconus and other keratoectatic disorders continues to be a challenge for today's cataract surgeon. In this article, we review data published over the past 18 months (June 2018 to January 2020). RECENT FINDINGS:Cataract surgery in keratoconus p...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000671

    authors: Smith RG,Knezevic A,Garg S

    更新日期:2020-07-01 00:00:00

  • Biologics in the treatment of uveitis.

    abstract:PURPOSE OF REVIEW:This review summarizes the current evidence for biologic therapies in the treatment of uveitis. The review emphasizes published research in this field since 2005. RECENT FINDINGS:The anti-tumour necrosis factor-alpha infliximab and adalimumab have demonstrated significant efficacy in controlling uvei...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3282f03d42

    authors: Imrie FR,Dick AD

    更新日期:2007-11-01 00:00:00

  • Use of botulinum toxin in strabismus.

    abstract:PURPOSE OF REVIEW:The history, pharmacology, indications, complications, and success rates of botulinum administration are discussed in this review as they relate to strabismus and associated conditions. RECENT FINDINGS:Botulinum has been used to treat strabismus and a variety of other ocular conditions for over three...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/01.icu.0000243018.97627.4c

    authors: Crouch ER

    更新日期:2006-10-01 00:00:00

  • Current treatments and preventive strategies for radiation retinopathy.

    abstract:PURPOSE OF REVIEW:Radiation retinopathy remains a devastating cause of visual morbidity in patients undergoing radiation for globe, orbit, and head and neck malignancies. This review discusses the recent efforts of several authors to treat radiation retinopathy once it has developed and efforts to prevent its developme...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000141

    authors: Reichstein D

    更新日期:2015-05-01 00:00:00

  • Trends in corneal transplantation: indications and techniques.

    abstract:PURPOSE OF REVIEW:To describe trends in corneal transplantation surgery, including indications for surgery, evolution of lamellar keratoplasty, current surgical techniques, and future directions. RECENT FINDINGS:Over the past decade, anterior and posterior lamellar keratoplasty have begun to supplant penetrating kerat...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000080

    authors: Ple-Plakon PA,Shtein RM

    更新日期:2014-07-01 00:00:00

  • Clinical management of retinoblastoma.

    abstract::There have been many recent advances in the diagnosis and management of children with retinoblastoma. Regarding diagnosis, the judicial use of ancillary studies, particularly B-scan ultrasonography, has been instrumental in supplementing the diagnosis when opaque media preclude a clear view of the underlying neoplasm...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199406000-00014

    authors: Shields JA,Shields CL,De Potter P

    更新日期:1994-06-01 00:00:00