Neuromyelitis optica: current concepts and prospects for future management.

Abstract:

PURPOSE OF REVIEW:To present an overview on the clinical manifestations and an update on the current management of neuromyelitis optica (NMO). RECENT FINDINGS:NMO is associated with a significant risk of neurological, ocular and systemic morbidity. Many cases of NMO assume a relapsing course, which can lead clinicians to mistake the disease for multiple sclerosis. Distinguishing between the two diseases can be accomplished by recognizing the differences in clinical manifestations, observing the clinical course, obtaining serological testing and appreciating the MRI features. It is also important to maintain a high index of suspicion for NMO in the appropriate clinical setting. SUMMARY:Clinical features of NMO include visual loss, decreased coordination, widespread asthenia, paraplegia, quadriplegia, and sensory impairment. Severe cases can result in bladder and bowel impairment or fatal respiratory failure. Symptomatic treatment and the currently available therapeutic agents can control the disease in many patients. However, given the lack of a curative treatment, the prognosis of NMO remains poor in some patients underscoring the need for drug development and controlled clinical trials focused on improved treatment strategies.

journal_name

Curr Opin Ophthalmol

authors

Hazin R,Khan F,Bhatti MT

doi

10.1097/ICU.0b013e3283313d1d

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

434-9

issue

6

eissn

1040-8738

issn

1531-7021

journal_volume

20

pub_type

杂志文章,评审
  • A new approach to the classification of neonatal corneal opacities.

    abstract:PURPOSE OF REVIEW:Neonatal corneal opacification (NCO) describes the loss of corneal transparency at or soon after (<4 weeks) birth. Historically, the literature is strewn with terminology that has been at best misleading and at worst, a hindrance to selecting the appropriate treatment plan for, accurate genotype-pheno...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e328356893d

    authors: Nischal KK

    更新日期:2012-09-01 00:00:00

  • Amblyopia.

    abstract::New knowledge of the pathophysiology of amblyopia has evolved through animal research over the past 30 years. We now know that development and treatment of amblyopia have a critical and sensitive period. After more than a millennium, patching of the dominant eye remains the cornerstone of amblyopia treatment, and comp...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199610000-00003

    authors: de Faber JT,Kingma-Wilschut C

    更新日期:1996-10-01 00:00:00

  • Neuro-ophthalmic manifestations of the phakomatoses.

    abstract:PURPOSE OF REVIEW:The phakomatoses are a group of inherited disorders with variable clinical manifestations that are characterized by brain, cutaneous, ocular and other distinct lesions in multiple organs. Correctly recognizing the neuro-ophthalmic signs and symptoms can lead to early diagnosis and treatment. The group...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000609

    authors: Douglas KAA,Douglas VP,Cestari DM

    更新日期:2019-11-01 00:00:00

  • Multifocal intraocular lenses.

    abstract::Since the publication of my last article in Current Opinion in Ophthalmology in 1991 (2:33-34), the use of multifocal intraocular lenses (IOLs) has not gained general acceptance among ophthalmologists. Despite this situation, major IOL companies have continued to invest in clinical trials of new designs. Recently, lar...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:

    authors: Pearce JL

    更新日期:1996-02-01 00:00:00

  • Cystoid macular edema following cataract surgery.

    abstract::Cystoid macular edema (CME) remains a troublesome problem after cataract surgery and other types of ocular surgical procedures. It is recognized as the most frequent cause of decreased vision in patients following cataract surgery. Although the disease was first described more than 40 years ago, its cause is unclear, ...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200002000-00010

    authors: Rossetti L,Autelitano A

    更新日期:2000-02-01 00:00:00

  • Contrast sensitivity: determining the visual quality and function of cataract, intraocular lenses and refractive surgery.

    abstract:PURPOSE OF REVIEW:This review provides an update of recent advances in understanding the quality and functional significance of contrast sensitivity for the clinician regarding cataract, intraocular lenses and refractive surgery that goes beyond the measurement of visual acuity. RECENT FINDINGS:New American National S...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/01.icu.0000192520.48411.fa

    authors: Ginsburg AP

    更新日期:2006-02-01 00:00:00

  • Management of irregular astigmatism.

    abstract::Using a liberal definition of corneal irregularity, modern videokeratoscopy may define approximately 40% of normal corneas with a toric refractive error as possessing primary irregular astigmatism. The causes of secondary forms of irregular astigmatism include corneal surgery, trauma, dystrophies, and infections. Inte...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200008000-00007

    authors: Goggin M,Alpins N,Schmid LM

    更新日期:2000-08-01 00:00:00

  • Toxic optic neuropathies.

    abstract:PURPOSE OF REVIEW:Many causes of toxic optic neuropathy have been described to date and novel causes of toxicity are continuously being added to the current literature. The pathophysiological basis for the toxicity or a direct causal relationship is yet to be determined for many of these agents. This review highlights ...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000001

    authors: Altiparmak UE

    更新日期:2013-11-01 00:00:00

  • Update on scleral lenses.

    abstract:PURPOSE OF REVIEW:Scleral rigid gas-permeable lenses play an important and underappreciated role in the treatment of corneal disease. This review provides an update on scleral rigid gas-permeable lenses for the visual rehabilitation of ectasia and irregular astigmatism, and an update on scleral rigid gas-permeable lens...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e328302cc4f

    authors: Jacobs DS

    更新日期:2008-07-01 00:00:00

  • Multifocal intraocular lenses in the setting of glaucoma.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to collate evidence and make recommendations regarding the use of multifocal intraocular lenses in patients with glaucoma. RECENT FINDINGS:Multifocal intraocular implants have been in use since the 1980s. Several studies have been done comparing their advantages and disa...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e328011d108

    authors: Kumar BV,Phillips RP,Prasad S

    更新日期:2007-02-01 00:00:00

  • Current and future applications of corneal cross-linking.

    abstract:PURPOSE OF REVIEW:To review current concepts and future directions of corneal cross-linking (CXL) as a treatment for keratoconus, ectasia after refractive surgery and infectious keratitis. RECENT FINDINGS:Several important laboratory and clinical studies have established the safety and success of corneal cross-linking...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000146

    authors: Khandelwal SS,Randleman JB

    更新日期:2015-05-01 00:00:00

  • Corneal wound healing.

    abstract:PURPOSE:To examine the latest theories in understanding wound healing, primarily as it pertains to refractive surgery but also, briefly, incisional surgery and nonsurgical corneal conditions (iatrogenic injury and noninfectious corneal ulcers). RECENT FINDINGS:Corneal wound healing involves transformation of fibroblas...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200408000-00006

    authors: Kuo IC

    更新日期:2004-08-01 00:00:00

  • Corneal complications of cataract surgery.

    abstract::Recent advances in cataract surgery have reduced the incidence of corneal complications. Review of the current literature reveals a trend toward early visual rehabilitation and minimization of postoperative astigmatism by careful selection of incision type and location for small-incision cataract surgery. Since the in...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199608000-00010

    authors: Batlan SJ,Dodick JM

    更新日期:1996-08-01 00:00:00

  • eyeGENE(R): a novel approach to combine clinical testing and researching genetic ocular disease.

    abstract:PURPOSE OF REVIEW:Molecular genetics is revolutionizing the diagnosis and treatment of inherited eye diseases. The National Eye Institute of the National Institutes of Health (NIH), in an effort to facilitate future basic and clinical research in inherited eye disease, created The National Ophthalmic Disease Genotyping...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32835715c9

    authors: Goetz KE,Reeves MJ,Tumminia SJ,Brooks BP

    更新日期:2012-09-01 00:00:00

  • Use of botulinum toxin in strabismus.

    abstract:PURPOSE OF REVIEW:The history, pharmacology, indications, complications, and success rates of botulinum administration are discussed in this review as they relate to strabismus and associated conditions. RECENT FINDINGS:Botulinum has been used to treat strabismus and a variety of other ocular conditions for over three...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/01.icu.0000243018.97627.4c

    authors: Crouch ER

    更新日期:2006-10-01 00:00:00

  • Does general anesthesia or intravitreal injection affect neurodevelopment in children undergoing ophthalmic procedures?

    abstract:PURPOSE OF REVIEW:To review recent studies on potential neurodevelopmental impacts on the pediatric population through general anesthesia events or intravitreal anti-vascular endothelial growth factor (VEGF) injection. RECENT FINDINGS:Studies on this topic have been extensive with varied reported neurodevelopmental ou...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000598

    authors: De Andrade LM,Isenberg SJ

    更新日期:2019-09-01 00:00:00

  • Strabismus surgery in the treatment of paralytic strabismus.

    abstract::Strabismus surgery may restore limited binocular function and improve cosmesis in patients with paralytic strabismus. Evaluation of the amount of residual function of the affected extraocular muscles is essential to determine which surgical procedure will yield the best results. Standard muscle resection techniques ar...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200112000-00005

    authors: Phillips PH

    更新日期:2001-12-01 00:00:00

  • Lymphomas involving the eye and the ocular adnexa.

    abstract:PURPOSE OF REVIEW:To describe recent advances in the understanding of the pathogenesis of the most common malignant lymphomas that occur as primary and secondary tumors in ocular tissues. RECENT FINDINGS:Advances have been made in the understanding of the genetic alterations in mucosa-associated lymphoid tissue lympho...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e328010948d

    authors: Coupland SE,Damato B

    更新日期:2006-12-01 00:00:00

  • Should patients with ocular genetic disorders have genetic testing?

    abstract:PURPOSE OF REVIEW:To discuss the risks, benefits and value of genetic testing for ocular genetic disease. RECENT FINDINGS:Testing for ocular genetics diseases is becoming more available and successful gene therapy is being reported. Clinicians must prepare for this trend by considering diagnostic genetic testing for t...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000083

    authors: Zanolli MT,Khetan V,Dotan G,Pizzi L,Levin AV

    更新日期:2014-09-01 00:00:00

  • Molecularly targeted agents in oculoplastic surgery.

    abstract:PURPOSE OF REVIEW:Significant advances have been made in oncology and rheumatology with the introduction of molecularly targeted agents (MTAs). MTAs consist of monoclonal antibodies and small molecule inhibitors. The purpose of this manuscript is to review the recent applications of MTAs to orbital, lacrimal, and eyeli...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000403

    authors: Allen RC

    更新日期:2017-09-01 00:00:00

  • Assessing abnormal head posture: a new paradigm.

    abstract:PURPOSE OF REVIEW:We aim to give a systematic approach on how to assess the cause of a patient's abnormal head posture (AHP). RECENT FINDINGS:Over the decades, many important clinical observers and teachers have described diagnostic techniques for patients with AHP. Recently, Wong has added a new set of office-based d...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e3283644f17

    authors: Halachmi-Eyal O,Kowal L

    更新日期:2013-09-01 00:00:00

  • Applied anatomy for the aesthetic surgeon.

    abstract:PURPOSE OF REVIEW:With the expanding view of the oculofacial surgeon as experts in the realm of aesthetic surgery, familiarity with facial anatomy is essential. The purpose of this review is to present an update on the relevant facial anatomy and its application on rejuvenation. RECENT FINDINGS:Numerous studies have r...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32833ce990

    authors: Oh SR,Priel A,Korn BS,Kikkawa DO

    更新日期:2010-09-01 00:00:00

  • Perioperative antibiotic, steroid, and nonsteroidal anti-inflammatory agents in cataract intraocular lens surgery.

    abstract::Ophthalmologists continue to choose topical antibiotics and corticosteroids more frequently than injectable agents for their current cataract surgical techniques. The preoperative use of povidone-iodine 5% and the postoperative use of impregnated soft contact lenses have helped augment our therapeutic armamentarium. N...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:

    authors: Abel R Jr,Abel AD

    更新日期:1997-02-01 00:00:00

  • Refractive lens exchange for myopia: a new perspective?

    abstract:PURPOSE OF REVIEW:Although lens surgery for high myopia has a long History, it has been extremely controversial. Colin's study of 1999 indicated a much higher than expected rate of retinal detachment. The purpose of this review is to reassess the place of refractive lens exchange in high myopia in the light of more rec...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-200502000-00009

    authors: Packard R

    更新日期:2005-02-01 00:00:00

  • Outcome of prematurity and retinopathy of prematurity.

    abstract::Retinopathy of prematurity is a disease that manifests soon after birth in the premature infant and may lead to a lifelong disability. More infants at risk for developing the retinopathy are surviving, and the ophthalmologist must be aware of possible vision abnormalities, such as decreased acuity, strabismus, nystagm...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/00055735-199606000-00009

    authors: Quinn GE,Dobson V

    更新日期:1996-06-01 00:00:00

  • Diagnosis and treatment of refractive errors in the pediatric population.

    abstract:PURPOSE OF REVIEW:The diagnosis and successful treatment of visually significant refractive errors in children are a subject of continued study and debate. RECENT FINDINGS:Treatment of significant refractive errors is widely accepted to reduce lifelong vision loss from amblyopia. Children aged 3-5 years may be screene...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e328244dfed

    authors: Braverman R

    更新日期:2007-09-01 00:00:00

  • The diagnosis of visual field progression in glaucoma.

    abstract::The detection of true visual field deterioration in glaucoma is of fundamental importance but is limited by inherent variability of the measurements. New techniques have been developed that use powerful statistical regression analysis methods to objectively quantify progression of visual field defects. These have be...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章

    doi:10.1097/00055735-199404000-00016

    authors: Fitzke FW,McNaught AI

    更新日期:1994-04-01 00:00:00

  • Update on botulinum toxin and dermal fillers.

    abstract:PURPOSE OF REVIEW:The art and science of facial rejuvenation is an ever-evolving field of medicine, as evidenced by the continual development of new surgical and nonsurgical treatment modalities. Over the past 10 years, the use of botulinum toxin and dermal fillers for aesthetic purposes has risen sharply. Herein, we d...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0b013e32833ce7bc

    authors: Berbos ZJ,Lipham WJ

    更新日期:2010-09-01 00:00:00

  • Ocular manifestations of West Nile virus.

    abstract:PURPOSE OF REVIEW:To review the ocular findings of patients with West Nile Virus. RECENT FINDINGS:Ocular findings have included multifocal choroiditis, vitritis, intraretinal hemorrhages, iritis, keratic precipitates, optic neuritis, branch retinal artery occlusions, and chorioretinal scarring in a case of intrauterin...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/01.icu.0000143687.45232.f1

    authors: Bakri SJ,Kaiser PK

    更新日期:2004-12-01 00:00:00

  • The evolution of toxic anterior segment syndrome.

    abstract:PURPOSE OF REVIEW:Toxic anterior segment syndrome (TASS) is a surgical complication resulting from a noninfectious inflammatory reaction to substances used during intraocular ophthalmic surgery. Continuous reporting of new information concerning risk factors and possible causes is critical for preventing this condition...

    journal_title:Current opinion in ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1097/ICU.0000000000000540

    authors: Shouchane-Blum K,Dotan A,Bahar I

    更新日期:2019-01-01 00:00:00