Ocular manifestations of systemic malignancies.

Abstract:

:Ocular manifestations of systemic malignancy are important for both the ophthalmologist and the internist to recognize because they may precede the diagnosis of cancer. This review of the current literature discusses the clinical manifestations, etiology, and potential therapeutic interventions for a group of visual paraneoplastic syndromes, including carcinoma-associated retinopathy and melanoma-associated retinopathy. These conditions are characterized by elevated serum levels of autoantibodies directed against tumor antigen that cross-react with retinal proteins, resulting in rod and cone dysfunction. The clinical presentation, site of origin, frequency, and intraocular distribution of tumors metastatic to the eye are also reviewed.

journal_name

Curr Opin Ophthalmol

authors

Solomon SD,Smith JH,O'Brien J

doi

10.1097/00055735-199912000-00013

keywords:

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

447-51

issue

6

eissn

1040-8738

issn

1531-7021

journal_volume

10

pub_type

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